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排序方式: 共有108条查询结果,搜索用时 15 毫秒
1.
Timofei S. Zatsepin Dmitry A. Stetsenko Tatiana S. Oretskaya 《Tetrahedron letters》2004,45(39):7327-7330
Oligodeoxyribonucleotides were synthesized that contain a novel nucleoside, 2′-O-(2-oxoethyl)arabinouridine. Whereas such oligonucleotides showed only a slight reduction in the TM values of their complexes with complementary DNA, a significant destabilization was observed in the case of duplexes formed with RNA. This may be explained by the C2′-endo conformation of 2′-O-(2,3-dihydroxypropyl)arabinouridine as demonstrated by NMR experiments in D2O. The modified oligonucleotides were used to synthesize a number of conjugates with dyes, biotin and a N-modified laminin peptide, by hydrazone and oxime formation. We suggest that the 2′-arabinoaldehyde-containing DNA duplexes may be valuable tools for affinity modification of DNA-binding proteins. 相似文献
2.
Abdurashitov JN Gavrin VN Girin SV Gorbachev VV Ibragimova TV Kalikhov AV Khairnasov NG Knodel TV Kornoukhov VN Mirmov IN Shikhin AA Veretenkin EP Vermul VM Yants VE Zatsepin GT Bowles TJ Nico JS Teasdale WA Wark DL Cherry ML Karaulov VN Levitin VL Maev VI Nazarenko PI Shkol'nik VS Skorikov NV Cleveland BT Daily T Davis R Lande K Lee CK Wildenhain PW Khomyakov YS Zvonarev AV Elliott SR Wilkerson JF 《Physical review letters》1996,77(23):4708-4711
3.
Abazov AI Anosov OL Faizov EL Gavrin VN Kalikhov AV Knodel TV Knyshenko II Kornoukhov VN Mezentseva SA Mirmov IN Ostrinsky AV Pshukov AM Revzin NE Shikhin AA Timofeyev PV Veretenkin EP Vermul VM Zatsepin GT Bowles TJ Cleveland BT Elliott SR O'Brien HA Wark DL Wilkerson JF Davis R Lande K Cherry ML Kouzes RT 《Physical review letters》1991,67(24):3332-3335
4.
Zatsepin A. F. Buntov E. A. Zatsepin D. A. Boqizoda D. A. Guseva M. B. Vyatkina S. P. Kas’yanova A. V. 《Physics of Atomic Nuclei》2018,81(11):1660-1663
Physics of Atomic Nuclei - The diversity of carbon materials has allowed them to be used for fundamental and applied research to date. The newest modifications of carbon, such as nanodiamonds,... 相似文献
5.
We have studied local configurations and vibration states of oxygen vacancies in different charge states in α-quartz. The local atomic structure and the lattice dynamics have been simulated using first-principles potentials of the Buckingham type. The effect of defects on the vibration spectrum of α-quartz has been studied by calculating the local densities of vibrational states. 相似文献
6.
Formation and electron-beam annealing of implantation defects in a thin-film Si-SiO2 heterostructure
Zatsepin A. F. Kaschieva S. Biryukov D. Yu. Dmitriev S. N. Buntov E. A. 《Technical Physics》2009,54(2):323-326
Technical Physics - The radiation-induced defects in a 20-nm-thick SiO2 film on a silicon wafer are studied by optically stimulated electron emission. Accelerated (12-keV) silicon ions is found to... 相似文献
7.
A. F. Zatsepin D. Yu. Biryukov V. S. Kortov S. O. Cholakh 《Physics of the Solid State》2002,44(9):1671-1675
The processes involved in the excited-state relaxation of hole O 1 0 centers at nonbridging oxygen atoms in glassy SiO2 were studied using luminescence, optical absorption, and photoelectron emission spectroscopy. An additional nonradiative relaxation channel, in addition to the intracenter quenching of the 1.9-eV luminescence band, was established to become operative at temperatures above 370 K. This effect manifests itself in experiments as a negative deviation of the temperature-dependent luminescence intensity from the well-known Mott law and is identified as thermally activated external quenching with an energy barrier of 0.46 eV. Nonradiative transitions initiate, within the external quenching temperature interval, the migration of excitation energy, followed by the creation of free electrons. In the final stages, this relaxation process becomes manifest in the form of spectral sensitization of electron photoemission, which is excited in the hole O 1 0 -center absorption band. 相似文献
8.
S. V. Gorbunov A. F. Zatsepin V. A. Pustovarov S. O. Cholakh V. Yu. Yakovlev 《Physics of the Solid State》2005,47(4):733-737
A time-resolved cathodo-and photoluminescence study of nanostructural modifications of Al2O3 (powders and ceramics) excited by heavy-current electron beams, as well as by pulsed synchrotron radiation, is reported. It was found that Al2O3 nanopowders probed before and after Fe+ ion irradiation have the same phase composition (the γ-phase/δ-phase ratio is equal to 1), an average grain size equal to ~17 nm, and practically the same set of broad cathodoluminescence (CL) bands peaking at 2.4, 3.2, and 3.8 eV. It was established that Al2O3 nanopowders exhibit fast photoluminescence (PL) (a band at 3.2 eV), whose decay kinetics is described by two exponential stages (τ1 = 0.5 ns, τ2 = 5.5 ns). Three bands, at 5.24, 6.13, and 7.44 eV, were isolated in the excitation spectrum of the fast PL. Two alternate models of PL centers were considered, according to which the 3.2-eV luminescence either originates from radiative relaxation of the P? centers (anion-cation vacancy pairs) or is due to the formation of surface analogs of the F+ center (F S + -type centers). In addition to the fast luminescence, nano-Al2O3 was found to produce slow luminescence in the form of a broad band peaking at 3.5 eV. The excitation spectrum of the 3.5-eV luminescence obtained at T = 13 K exhibits two doublet bands with maxima at 7.8 and 8.3 eV. An analysis of the luminescent properties of nanostructural and single-crystal Al2O3 suggests that the slow luminescence of nanopowders at 3.5 eV is due to radiative annihilation of excitons localized near structural defects. 相似文献
9.
P. G. Sveshnikov T. A. Yagudin E. V. Morozkina E. V. Klyachko S. S. Zatsepin S. V. Benevolensky O. B. Shemchukova L. P. Pozdnyakova O. N. Solopova 《Moscow University Chemistry Bulletin》2010,65(3):154-158
This paper describes the production of a functional humanized Fab fragment of a neutralizing antibody against the rabies virus.
It is a prototype of a therapeutic agent that could be an alternative to equine anti-rabies immunoglobulins and anti-rabies
serum immunoglobulins obtained from the blood of vaccinated human donors. Variable fragments of the high-affinity light and
heavy chains neutralizing an antibody against the rabies virus were cloned and sequenced. Mouse constant regions were replaced
by human constant regions followed by expression of the humanized Fab fragments in a yeast expression system. The immunochemical
properties of the Fab fragments were evaluated using ELISA, polyacrylamide gel electrophoresis, and the Western blot assay.
The binding capability of the produced humanized Fab fragments surpasses that of the parental antibody. A high degree of humanization
was confirmed using sera against human immunoglobulins. The yield of the humanized Fab fragments was 21 mg per liter of culture
medium. The purified Fab fragment preparation did not contain traces of the isolated light and heavy chains of the humanized
Fab fragments. 相似文献
10.
N. Yu. Agafonova V. V. Boyarkin V. L. Dadykin E. A. Dobrynina R. I. Enikeev A. S. Malgin O. G. Ryazhskaya V. G. Ryasny I. R. Shakiryanova V. F. Yakushev G. T. Zatsepin 《Bulletin of the Russian Academy of Sciences: Physics》2011,75(3):408-410
The large geometric factor and good spatial resolution of the Large Volume Detector (LVD) ensures statistically significant and highly accurate measurements of muon trajectories and determination of the multiplicity of muon groups. The developed algorithm allows us to reconstruct 2 × 106 muon events (single muons and muon groups). Characteristics of muon groups are obtained and the specific yield of neutrons produced by single muons, muon groups, and showers is determined. 相似文献