奋乃静和氟奋乃静的毛细管电泳柱端喷壁式安培检测

应用自组装毛细管电泳．安培检测装置，建立了同时分离检测抗精神病药奋乃静与氟奋乃静的新方法。在1050mV(vs．Ag／AgCl)检测电位下，奋乃静与氟奋乃静的检出限分别达0．060mg／L与0．075mg／L。在最佳检测条件下，两组分的响应电流与浓度之间有着良好的线性关系，线性范围为0．75～75mg／L。将方法用于药物片剂以及模拟尿样和血清样品中奋乃静和氟奋乃静的测定，结果令人满意。     

Synthesis and characterization of aniline and aniline-o-sulfonic acid copolymers

The copolymer of aniline (An) and aniline-o-sulfonic acid (AS) is synthesized by chemical oxidation polymerization. The effects of mole ratio of copolymerized monomers on chain structure, thermostability, conductivity, redox properties of copolymer are discussed. It is indicated that if more AS monomers in polymerization system the corresponding structure units will increase, but their relation isn’t linear. When An:AS = 1:1, the ratio of structure unit in copolymer is 9:1, and it is only 1:2 for copolymer with An:AS = 1:6. The measurements of conductivity and redox activity also prove that the properties of An-co-AS(1:1), (1:3), and (1:4) are similar to polyaniline due to more An units than AS. When An:AS is higher than 1:6, it shows out the properties of copolymer is similar to those of poly(aniline-o-sulfonic acid), and their redox route is different. They will transform to follow the route of LH ↔ EH ↔ P. The results of thermo-analysis indicate that the decomposition temperature of AS units is lower than An units because of the electron-withdrawing group substitution. The decomposition temperature of polymer is related to dopant and doping degree. Electron-withdrawing group, -SO₃H, substitution and HCl doping will decrease polymer chain decomposition temperature. The mechanism of copolymerization of An and AS is different from homopolymerization. The monomer with low oxidation potential forms free radical cation firstly, which transfers to monomer with higher oxidation potential and initiates its polymerization.     

Some Properties of Solutions to the Novikov Equation with Weak Dissipation Terms

In this paper, we investigate the Novikov equation with weak dissipation terms. First, we give the local well-posedness and the blow-up scenario. Then, we discuss the global existence of the solutions under certain conditions. After that, on condition that the compactly supported initial data keeps its sign, we prove the infinite propagation speed of our solutions, and establish the large time behavior. Finally, we also elaborate the persistence property of our solutions in weighted Sobolev space.     

Wide-stripe noise removal method of hyperspectral image based on fusion of wavelet transform and local interpolation

Optical Review - The principle of hyperspectral imaging leads to a variety of stripe noise in hyperspectral images, especially the wide-stripe noise, which brings great obstacles to the...     

SPE HG-AAS method for the determination of inorganic arsenic in rice—results from method validation studies and a survey on rice products

The present paper describes the development, validation and application of a method for inorganic arsenic (iAs) determination in rice samples. The separation of iAs from organoarsenic compounds was done by off-line solid-phase extraction (SPE) followed by hydride generation atomic absorption spectrometry (HG-AAS) detection. This approach was earlier developed for seafood samples (Rasmussen et al., Anal Bioanal Chem 403:2825–2834, 2012) and has in the present work been tailored for rice products and further optimised for a higher sample throughput and a lower detection limit. Water bath heating (90 °C, 60 min) of samples with dilute HNO₃ and H₂O₂ solubilised and oxidised all iAs to arsenate (As^V). Loading of buffered sample extracts (pH 6?±?1) followed by selective elution of arsenate from a strong anion exchange SPE cartridge enabled the selective iAs quantification by HG-AAS, measuring total arsenic (As) in the SPE eluate. The in-house validation gave mean recoveries of 101–106 % for spiked rice samples and in two reference samples. The limit of detection was 0.02 mg kg^?1, and repeatability and intra-laboratory reproducibility were less than 6 and 9 %, respectively. The SPE HG-AAS method produced similar results compared to parallel high-performance liquid chromatography coupled to inductively coupled plasma mass spectrometry (ICP-MS) analysis. The SPE separation step was tested collaboratively, where the laboratories (N?=?10) used either HG-AAS or ICP-MS for iAs determination in a wholemeal rice powder. The trial gave satisfactory results (HorRat value of 1.6) and did not reveal significant difference (t test, p?>?0.05) between HG-AAS and ICP-MS quantification. The iAs concentration in 36 rice samples purchased on the Danish retail market varied (0.03–0.60 mg kg^?1), with the highest concentration found in a red rice sample.      

Neuroprotection of N-benzyl Eicosapentaenamide in Neonatal Mice Following Hypoxic–Ischemic Brain Injury

Maca (Lepidium meyenii) has emerged as a popular functional plant food because of its medicinal properties and nutritional value. Macamides, as the exclusively active ingredients found in maca, are a unique series of non-polar, long-chain fatty acid N-benzylamides with multiple bioactivities such as antifatigue characteristics and improving reproductive health. In this study, a new kind of macamide, N-benzyl eicosapentaenamide (NB-EPA), was identified from maca. We further explore its potential neuroprotective role in hypoxic–ischemic brain injury. Our findings indicated that treatment with biosynthesized NB-EPA significantly alleviates the size of cerebral infarction and improves neurobehavioral disorders after hypoxic–ischemic brain damage in neonatal mice. NB-EPA inhibited the apoptosis of neuronal cells after ischemic challenge. NB-EPA improved neuronal cell survival and proliferation through the activation of phosphorylated AKT signaling. Of note, the protective property of NB-EPA against ischemic neuronal damage was dependent on suppression of the p53–PUMA pathway. Taken together, these findings suggest that NB-EPA may represent a new neuroprotectant for newborns with hypoxic–ischemic encephalopathy.     

Tin (IV) chloride-promoted one-pot synthesis of novel tacrine analogues

A facile synthesis of potential acetylcholinesterase (AChE) inhibitors, the tacrine analogues 3a-p, has been accomplished by direct cyclocondensation of 1-aryl-4-cyano-5-aminopyrazole with β-ketoesters using tin(IV) chloride as catalyst. The structures of all the compounds have been confirmed by IR, 1H- and 13C-NMR.     

Characterization of optoelectronic properties of the ZnO nanorod array using surface photovoltage technique

Well-aligned ZnO nanorod array, synthesized by wet chemical bath deposition (CBD) method on conductive indium-in-oxide (ITO) substrate, was characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and photoluminescence (PL) spectroscopy. Surface photovoltage (SPV) technique based on a scanning Kelvin Probe system was employed to investigate the optoelectronic behavior of ZnO nanorod array. The surface photovoltage and its time-resolved evolution process are used to determine the energy level structure of the ZnO nanorod array.     

Blow-up problems for nonlinear parabolic equations on locally finite graphs

Let G=(V,E) be a locally finite connected weighted graph, and Δ be the usual graph Laplacian. In this article, we study blow-up problems for the nonlinear parabolic equation u_t=Δu + f(u) on G. The blow-up phenomenons for u_t=Δu + f(u) are discussed in terms of two cases: (i) an initial condition is given; (ii) a Dirichlet boundary condition is given. We prove that if f satisfies appropriate conditions, then the corresponding solutions will blow up in a finite time.