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Yi Sun Nam-Trung Nguyen Yien Chian Kwok 《Analytical and bioanalytical chemistry》2009,394(6):1707-1710
Joule heating generated by the electrical current in capillary electrophoresis leads to a temperature gradient along the separation
channel and consequently affects the separation quality. We describe a method of reducing the Joule heating effect by incorporating
photonic crystal fiber into a micro capillary electrophoresis chip. The photonic crystal fiber consists of a bundle of extremely
narrow hollow channels, which ideally work as separation columns. Electrophoretic separation of DNA fragments was simultaneously
but independently carried out in 54 narrow capillaries with a diameter of 3.7 μm each. The capillary bundle offers more efficient
heat dissipation owing to the high surface-to-volume ratio. Under the same electrical field strength, notable improvement
in resolution was obtained in the capillary bundle chip. 相似文献
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We report on a novel concept of sample loading for microfluidic devices using a benchtop centrifuge and a magnetically actuated circular closed-loop PCR microchip as a model system. The PCR mixture and the ferrofluid were loaded into a specially designed microchip. The microchip was then placed in an off-the-shelf 50-mL tube and centrifuged. The strong centrifugal force drives the PCR mixture and the ferrofluid into the microchannels of the microchip, and simultaneously expels any trapped microbubbles. PCR was successfully carried out on single and parallel closed-loop PCR microchips. The addition of a few off-chip handling steps allows great simplification of the device design. This new loading concept may be useful for designing robust and low-cost lab-on-a-chip devices because benchtop centrifuges are quite common in most laboratories. Figure
This paper reports a novel concept of sample loading for microfluidic devices using a benchtop centrifuge. The addition of a few simple off-chip handling steps allows designing robust and low-cost lab-on-a-chip devices. 相似文献
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Bruins EE Bauer TS den Bok HW Duif CP van Hoek WC de Lange DJ Misiejuk A Papandreou Z Sichtermann EP Tjon JA Willering HW Yeomans DM Reike H Durek D Frommberger F Gothe R Jakob D Kranefeld G Kunz C Leiendecker N Pfeiffer G Putsch H Reichelt T Schoch B Wacker D Wehrmeister D Wilhelm M Jans E Konijn J de Vries R Furget C Voutier E Arenhövel H 《Physical review letters》1995,75(1):21-24
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Complex physiologic signals may carry unique dynamical signatures that are related to their underlying mechanisms. We present a method based on rank order statistics of symbolic sequences to investigate the profile of different types of physiologic dynamics. We apply this method to heart rate fluctuations, the output of a central physiologic control system. The method robustly discriminates patterns generated from healthy and pathologic states, as well as aging. Furthermore, we observe increased randomness in the heartbeat time series with physiologic aging and pathologic states and also uncover nonrandom patterns in the ventricular response to atrial fibrillation. 相似文献