Basic function method A new numerical method on unstructured grids

A new numerical method-basic function method is proposed. This method can directly discrete differential operators on unstructured grids. By using the expansion of basic function to approach the exact function, the central and upwind schemes of derivative are constructed. By using the polynomial as basic function, applying the technique of flux splitting method and the combination of central and upwind schemes, the non-physical fluctuation near the shock wave is suppressed. The first-order basic function scheme of polynomial type for solving inviscid compressible flow numerically is constructed in this paper. Several numerical results of many typical examples for one-, two- and three-dimensional inviscid compressible steady flow illustrate that it is a new scheme with high accuracy and high resolution for shock wave. Especially, combining with the adaptive remeshing technique, the satisfactory results can be obtained by these schemes.     

Tunable resonance frequency of FeNi films by oblique sputtering

FeNi thin films were fabricated by radio frequency magnetron sputtering on Si(1 1 1). Dynamic properties at remanence of the films were systematically investigated in a wide frequency range from 100 MHz to 5 GHz. The results show that both thickness of FeNi films and oblique angle have important effects on the magnetic properties of the films, the magnetic resonant frequency of the films can also be adjusted by the two factors. The in-plane uniaxial magnetic anisotropy field can be adjusted from 82 Oe to 220 Oe by increasing the oblique angle. As a consequence, the magnetic resonant frequency of the films increased from 2.7 GHz to 4.2 GHz.     

Total synthesis of Resolvin E1

The enantioselective total synthesis of Resolvin E1 (RvE1), a naturally occurring small molecule mediator of inflammation resolution, is reported. Two routes are presented, both modular and convergent in nature, with an excellent control of all stereocenters. The C12- and C18-hydroxy groups are derived from (S)-glycidol while the C5-hydroxy group is installed via enantioselective reduction of a ketone precursor. Both the cis-alkenes are introduced with excellent control by the reduction of a late-stage bis-alkyne intermediate. The synthetic disconnections are very amenable to analog preparation, and further modifications to the chemistry have allowed for scale-up and First in Man testing of this novel pro-resolution molecule.     

Basic function method

Science China Physics, Mechanics & Astronomy - A new numerical method-basic function method is proposed. This method can directly discrete differential operators on unstructured grids. By using...     

The theoretical research of basic function method in incompressible viscous flow and its simulations in three-dimensional aneurysms

Basic function method is developed to treat the incompressible viscous flow. Artificial compressibility coefficient, the technique of flux splitting method and the combination of central and upwind schemes are applied to construct the basic function scheme of trigonometric function type for solving three-dimensional incompressible Navier-Stokes equations numerically. To prove the method, flows in finite-length-pipe are calculated, the velocity and pressure distribution of which solved by our method quite coincide with the exact solutions of Poiseuille flow except in the areas of entrance and exit. After the method is proved elementary, the hemodynamics in two- and three-dimensional aneurysms is researched numerically by using the basic function method of trigonometric function type and unstructured grids generation technique. The distributions of velocity, pressure and shear force in steady flow of aneurysms are calculated, and the influence of the shape of the aneurysms on the hemodynamics is studied. Supported by the National Natural Foundation of China (Grant Nos. 40874077, 40504020, and 40536029) and the National Basic Research Program of China (Grant No. 2006CB806304)     

A novel adenosine-based molecular beacon probe for room temperature nucleic acid rapid detection in cotton thread device

We used cotton thread as substrate to develop a novel room temperature DNA detection device for low-cost, sensitive and rapid detection of a human genetic disease, hereditary tyrosinemia type I related DNA sequences. A novel adenosine based molecular beacon (ABMB) probe modified on gold nanoparticle was used as reporter probe. In the presence of coralyne, a small molecule which can react with adenosines, the ABMB would form a hairpin structure just like traditional molecular beacon used extensively. In the presence of target DNA sequences, the hairpin structure of ABMB modified on gold nanoparticles will be opened and the biotin group modified at one end of the DNA probes will be released and react with the streptavidin immobilized on the test zone of the cotton thread. The response of the thread based DNA test device is linear over the range of 2.5–100 nM complementary DNA. The ability of our developed device for discriminating the single base mismatched DNA related to a human genetic disease, hereditary tyrosinemia type I, was improved comparing with previous report. It is worth mentioning that the whole assay procedure for DNA test is performed under room temperature which simplified the assay procedures greatly.