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1.
In this paper we have analyzed the Kaluza-Klein type Robertson Walker (RW) cosmological models by considering three different
forms of variable Λ:
,
and Λ∼ρ. It is found that, the connecting free parameters of the models with cosmic matter and vacuum energy density parameters are
equivalent, in the context of higher dimensional space time. The expression for the look back time, luminosity distance and
angular diameter distance are also derived. This work has thus generalized to higher dimensions the well-known results in
four dimensional space time. It is found that there may be significant difference in principle at least, from the analogous
situation in four dimensional space time. 相似文献
2.
Harshad S. Kapare Ranjitsinh Pawar Vrushali Neve Vrushali Bhalchim Prabhanjan S. Giram 《先进技术聚合物》2024,35(3):e6348
In recent years, advanced polymeric dendrimers have emerged as a promising avenue for AD management. Dendrimers are highly branched, three-dimensional macromolecules with precise nanoarchitectures, making them ideal candidates for the delivery of therapeutic agents and diagnostic tools. Their unique properties, such as well-defined size, multifunctionality, and controlled surface chemistry, allow for the design of targeted and highly efficient drug delivery systems and diagnostic probes. This review aims to provide a comprehensive overview of the potential applications of advanced polymeric dendrimers in the management of Alzheimer's disease. We explored their role in drug delivery, diagnostics, and other therapeutic interventions for AD. Additionally, we will delve into the challenges and opportunities in utilizing dendrimers as a key player in the battle against this devastating disease. The review will begin by discussing the current state of Alzheimer's disease, including its pathological features, clinical manifestations, and existing treatment strategies. It will then transition to an in-depth examination of polymeric dendrimers, highlighting their structural characteristics, synthesis methods, and biocompatibility. Subsequently, the review will delve into the various ways in which dendrimers can be tailored for AD management, including drug encapsulation and delivery, enhanced blood–brain barrier penetration, and targeted diagnostic imaging. Furthermore, we explored the potential benefits of dendrimer-based therapies, such as improved drug efficacy, reduced side effects, and enhanced patient compliance. The review will also address the challenges associated with dendrimer-based approaches, including toxicity concerns, regulatory hurdles, and the need for rigorous clinical evaluation. 相似文献
3.
4.
Vrushali H. Jadhav Omprakash P. Bande Vedavati G. Puranik Dilip D. Dhavale 《Tetrahedron: Asymmetry》2010,21(2):163-170
The Sharpless asymmetric epoxidation of d-glucose-derived allyl alcohol 4 afforded α- and β-epoxides 5a and 5b in high stereoselectivity. The epoxide ring opening in 5a/5b was studied with different nucleophilic azido reagents, under various reaction conditions, and was found to be highly regioselective to give the preferential formation of 6-azido diol 6a/6b over 5-azido-diol 7a/7b. The 6-azido diol 6a/6b and 5-azido diol 7a/7b thus obtained were converted to the corresponding seven- and six-membered iminosugar, namely, azepane 1a/1b and 1-deoxy-nojirimycin 2a/2b. 相似文献
5.
The optical properties of MnAl films of different compositions, deposited at different substrate temperatures and in the thickness range 25 to 90 nm, are reported. The reflectance and transmittance are measured in the wavelength range 320–900 nm for near normal incidence of light. These measurements are used to calculate the optical constants namely, refractive index (n) and extinction coefficient (k). The wavelength and thickness dependence of these optical constants are reported. The optical measurements for films with higher Mn content and grown at higher substrate temperature reveal that n and k values are constant over a wide wavelength range (500–900 nm) showing high reflectance in the visible and near infrared region. 相似文献
6.
Prof. Dr. Ningond S. Biradar Subhaschandra D. Angadi 《Monatshefte für Chemie / Chemical Monthly》1977,108(3):525-532
Complexes of uranyl chloride with fiveSchiff bases have been prepared. The dioxouranium (VI) forms 12 adducts with theseSchiff bases. With the help of conductivity, analytical, UV, IR and NMR data, it has been shown that these complexes have coordination number eight with hexagonal bipyramid structure. 相似文献
7.
Sanjeevagowda T. Patil Mahantesh A. Angadi Abdulazizkhan L. Harihar 《Journal of solution chemistry》2008,37(12):1795-1808
The kinetics of the oxidation of L-asparagine, (L-asp) by diperiodatonickelate(IV), (DPN) in aqueous alkaline medium at a
constant ionic strength of 0.5 mol⋅dm−3, was studied spectrophotometrically. The reaction is first order in [DPN] and of fractional order in both [L-asp] and [alkali].
Addition of the products has no significant effect on the reaction rate. However, increasing the ionic strength or decreasing
the dielectric constant of the medium increases the reaction rate. The oxidation process in alkaline medium is shown to proceed
via two paths, one involving the interaction of L-asparagine with diperiodatonickelate(IV) ion in a slow step to yield the
products, and the other path involving the interaction of alkali with the diperiodatonickelate(IV) ion to give nickel(II).
Some reaction constants involved in the mechanism were determined, and calculated and observed rate constants are in excellent
agreement. The activation parameters were computed for the slow step of the mechanism. 相似文献
8.
A simple, rapid, and accurate method based on thin-layer chromatography (TLC) combined with image-analysis software has been developed for analysis of steroid drug intermediates formed during bioconversion of soysterols. The results obtained have been compared with those from LC. The method has been used to monitor the accumulation of widely used steroid drug intermediates androst-4-ene-3,17-dione (AD) and androsta-1,4-diene-3,17-dione (ADD), formed during the bioconversion of soysterols by Mycobacterium sp. NRRL B-3805 and Mycobacterium sp. NRRL B-3683. The percentage error between TLC and LC ranged between ?0.79 to +4.50 for AD and ?0.61 to +2.48 for ADD. Maximum conversion of soysterols to AD and ADD by Mycobacterium sp. NRRL B-3805 was 49.83 and 9.36 mol%, respectively, after incubation for 144 h, whereas conversion of soysterols by Mycobacterium sp. NRRL B-3683 after incubation 288 h was 41.90 mol% for AD and 37.79 mol% for ADD. 相似文献
9.
A study of the effect of introduction of 3,6-anhydroglucose residues in the cellulose structure on glycoside hydrolysis rate was performed. A cellotetrose with an 3,6-anhydroglucose as the third residue was synthesised. Acidic hydrolysis of this tetrasaccharide showed that hydrolysis of the 3,6-anhydro-β-D-glucoside linkage was 31.400 times faster than hydrolysis of cellobiose. A series of different 3,6-anhydrocelluloses with different degree of substitution were prepared by tosylation of cellulose with varying amounts of tosyl chloride in dimethylacetamide and subsequent treatment with sodium hydroxide. Anhydrocelluloses with degrees of substitution of 0.02, 0.07, 0.31 and 0.74 were obtained. The anhydrocelluloses were subjected to acidic hydrolysis in 2.0 M aqueous HCl and the rate of hydrolysis monitored by ion chromatography analysis of the amount of glucose and/or cellobiose formed. All 3,6-anhydrocelluloses hydrolyzed with a faster rate than cellulose, but the anhydrocellulose with a low degree of substitution (ds = 0.07) hydrolyzed fastest which was 90 times faster than cellulose. 相似文献
10.
K. Sharanabasamma Mahantesh A. Angadi Manjalee S. Salunke Suresh M. Tuwar 《Journal of solution chemistry》2012,41(2):187-199
The kinetics of oxidation of L-valine by a copper(III) periodate complex was studied spectrophotometrically. The inverse second-order
dependency on [OH−] was due to the formation of the protonated diperiodatocuprate(III) complex ([Cu(H3IO6)2]−) from [Cu(H2IO6)2]3−. The retarding effect of initially added periodate suggests that the dissociation of copper(III) periodate complex occurs
in a pre-equilibrium step in which it loses one periodate ligand. Among the various forms of copper(III) periodate complex
occurring in alkaline solutions, the monoperiodatocuprate(III) appears to be the active form of copper(III) periodate complex.
The observed second-order dependency of [L-valine] on the rate of reaction appears to result from formation of a complex with
monoperiodatocuprate(III) followed by oxidation in a slow step. A suitable mechanism consistent with experimental results
was proposed. The rate law was derived as:
- \fracd[DPC]dt = \frackK1K2K3[Cu(H2IO6)2]f3- [L -Val]f2[H3IO62 -]f[OH - ]f2.- \frac{\mathrm{d}[\mathrm{DPC}]}{\mathrm{d}t} =\frac{kK_{1}K_{2}K_{3}[\mathrm{Cu}(\mathrm{H}_{2}\mathrm{IO}_{6})_{2}]_{\mathrm{f}}^{3-} [\mathrm{L} -\mathrm{Val}]_{\mathrm{f}}^{2}}{[\mathrm{H}_{3}\mathrm{IO}_{6}^{2 -}]_{\mathrm{f}}[\mathrm{OH}^{ -} ]_{\mathrm{f}}^{2}}. 相似文献 |