An Isocyanide‐Based Multicomponent Reaction: New Route for Synthesis of Isoxazolinedione Derivatives

An efficient and novel multicomponent reaction for synthesis of new isoxazolinedione has been described. This protocol involves reaction of two molecules of isocyanide, aliphatic oxime, alkylidene substituted Meldrum's acid, and water (moisture). Elemental analyses, IR, ¹H NMR, and ¹³C NMR spectroscopic data of products are consistent with the structure defined by X‐ray diffraction analysis.     

Synthesis and evaluation of novel arylisoxazoles linked to tacrine moiety: in vitro and in vivo biological activities against Alzheimer’s disease

Molecular Diversity - Alzheimer’s disease (AD) is now ranked as the third leading cause of death after heart disease and cancer. There is no definite cure for AD due to the multi-factorial...