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1.
Yu. V. Kistenev E. B. Bukreeva A. A. Bulanova D. A. Kuzmin S. A. Tuzikov E. L. Yumov 《Physics of Wave Phenomena》2014,22(3):210-215
The specificity of exhaled air spectra in the range from 9.2 to 10.6 µm for patients with lung cancer and chronic obstructive pulmonary disease has been analyzed by laser spectroscopy and chemometrics methods. The informativeness of the absorption spectra of exhaled air is compared with that of clinical analysis data. 相似文献
2.
Nikolay E. Nifant'ev Yury E. Tsvetkov Alexander S. Shashkov Leonid O. Kononov Vladimir M. Menshov Alexander B. Tuzikov 《Journal of carbohydrate chemistry》2013,32(8):939-953
ABSTRACT Synthesis of two isomeric tetrasaccharides, namely Neu5Acα(2→3)Galβ(1→3)[Fucα(1→4)GlcNAcβ (sLea) and Neu5Acα(2→3)Galβ(1→4)[Fucα(1→3)]GlcNAcβ (sLex) as 3-aminopropyl glycosides is described. Preparation of these compounds was performed by sialylation of selectively protected trisaccharides Lea and Lex which contain three unsubstituted OH groups at positions 2, 3 and 4 of Gal residue. Glycosylation of Lex trisaccharide with ethylthio sialoside under promotion by NIS and TfOH in acetonitrile was effective and regio- and stereoselective to give sLex derivative in 81% yield. In contrast, sialylation of the Lca acceptor was accompanied by a variety of undesirable by-processes, namely. N-thioethylation of the GlcNAc residue, β-sialylation, and lactonisation. In order to improve the yield of sLca tetrasaccharide the glycosylation of Lea acceptor by sialyl donors of ethyl and phenyl thioglycoside (promoted by NIS-TfOH or NBS-Bu4NBr), xanthate (promotion by NIS-TfOH mixture or MeOTf) and phosphite (promoted by TMSOTf) types was also studied. Among the reactions investigated the glycosylation by phenyl thioglycoside sialoside promoted by NIS-TfOH gives the best yield (39%) of sLea tetrasaccharide product. 相似文献
3.
Filatov G. A. Slivin A. Syresin E. M. Butenko A. V. Chesnov A. F. Parfilo T. Tuzikov A. V. 《Physics of Particles and Nuclei Letters》2020,17(4):434-437
Physics of Particles and Nuclei Letters - A new accelerator complex with new beam lines for applied research is being constructed at the Joint Institute for Nuclear Research (Dubna, Russia) as part... 相似文献
4.
Kostromin S. A. Kozlov O. S. Tuzikov A. V. Philippov A. V. 《Physics of Particles and Nuclei Letters》2020,17(4):447-452
Physics of Particles and Nuclei Letters - The optimization of the optical structure of the NICA Collider is presented. The Collider optics settings are given for a working point of 9.44/9.44 and a... 相似文献
5.
Galanina O Feofanov A Tuzikov AB Rapoport E Crocker PR Grichine A Egret-Charlier M Vigny P Le Pendu J Bovin NV 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》2001,57(11):2285-2296
Fluorescein labeled carbohydrate (Glyc) probes were synthesized as analytical tools for the study of cellular lectins, i.e. SiaLe(x)-PAA-flu, Sia2-PAA-flu, GlcNAc2-PAA-flu, LacNAc-PAA-flu and a number of similar ones, with PAA a soluble polyacrylamide carrier. The binding of SiaLe(x)-PAA-flu was assessed using CHO cells transfected with E-selectin, and the binding of Sia2-PAA-flu was assessed by COS cells transfected with siglec-9. In flow cytometry assays, the fluorescein probes demonstrated a specific binding to the lectin-transfected cells that was inhibited by unlabeled carbohydrate ligands. The intense binding of SiaLe(x)-PAA-3H to the E-selectin transfected cells and the lack of binding to both native and permeabilized control cells lead to the conclusion that the polyacrylamide carrier itself and the spacer arm connecting the carbohydrate moiety with PAA did not contribute anymore to the binding. Tumors were obtained from nude mice by injection of CHO E-selectin or mock transfected cells. The fluorescent SiaLe(x)-PAA-flu probe could bind to the tumor sections from E-selectin positive CHO cells, but not from the control ones. Thus, these probes can be used to reveal specifically the carbohydrate binding sites on cells in culture as well as cells in tissue sections. The use of the confocal spectral imaging technique with Glyc-PAA-flu probes offered the unique possibility to detect lectins in different cells, even when the level of lectin expression was rather low. The confocal mode of spectrum recording provided an analysis of the probe localization with 3D submicron resolution. The spectral analysis (as a constituent part of the confocal spectral imaging technique) enabled interfering signals of the probe and intrinsic cellular fluorescence to be accurately separated, the distribution of the probe to be revealed and its local concentration to be measured. 相似文献
6.
Butenko A. V. Galimov A. R. Meshkov I. N. Syresin E. M. Tolstikhina I. Yu. Tuzikov A. V. Philippov A. V. Khodzhibagiyan H. G. Shevel’ko V. P. 《JETP Letters》2021,113(12):752-756
JETP Letters - The results of the first run (December 2020) for the commissioning of the new superconducting synchrotron Booster at the Joint Institute for Nuclear Research are presented. Vacuum... 相似文献
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8.
A. V. Tuzikov V. S. Aleksandrov V. F. Shevtsov 《Physics of Particles and Nuclei Letters》2006,3(1):S30-S33
In this report, the beam dynamics in the magnetic field defined by the integral expression of the vector potential is considered. The influence of transverse components of the magnetic field on the shift of the beam trajectory in the helical solenoid of the LUE-200 accelerator of the IREN setup (Joint Institute for Nuclear Research, Dubna) is analyzed. 相似文献
9.
Sidorov A. I. Tuzikov A. V. Shvetsov V. S. Golubev I. I. Kozlov A. P. Lepkin M. P. 《Physics of Particles and Nuclei Letters》2020,17(4):528-530
Physics of Particles and Nuclei Letters - The design of a high-voltage collet with movable external and internal conductors is considered. The design of the grip connection, the choice of material... 相似文献
10.
A new contrasting procedure is proposed for studying supported catalysts and functional materials by small-angle scattering. The main advantage over earlier analogues is the use of new masking liquids, which possess very low X-ray absorption at a relatively high density. A number of supported catalysts were studied using the new procedure, and almost complete agreement of the particle-size distributions of supported metals with transmission electron-microscopic data was demonstrated. The use of the new contrasting procedure on a typical small-angle diffractometer makes it possible to obtain the particle-size distributions of metals in supported catalysts containing noble metals at a level to 0.1 wt %. 相似文献