ABSTRACTWe report the unexpected observation of columnar mesophase formation in a simple 2,7-dibromotetramethoxytriphenylene – by far the most lightly substituted discotic mesogen in this class. This derivative was prepared alongside the 3,6-dibromotriphenylene isomer to demonstrate an alternative, modified synthetic strategy that permits late-stage interchange of alkyl chain substituents. The new method is employed alongside the original route to deliver several new materials, including a conjugated ferrocene–triphenylene–ferrocene triad, a BODIPY–triphenylene–BODIPY triad and a new nematic twin linked through imine bridges. 相似文献
A recently discovered 2D transition titanium metal carbides also called as MXenes (Ti3C2Tx)-based nanocomposite was prepared with Cu2O through wet precipitation technique, and these materials were further developed as the electrode for sensing glucose by chronoamperometry technique. The prepared MXene-Cu2O (Ti3C2Tx-Cu2O) nanocomposite was characterized by XRD, FTIR, UV–Vis spectroscopy, FE-SEM, EDAX, and Raman spectroscopy. Morphological studies of the composites revealed that the micro-octahedral shape of Cu2O is distributed on the surface of MXene with size larger than bare Cu2O. Further, the prepared composite material was fabricated as a sensing probe, and the electrochemical activities were examined by cyclic voltammetric analysis (CV) and chronoamperometric (CA) methods. From the CV and CA investigation, the current response was higher for the composite than the bare material (Cu2O & MXene) in the presence of glucose. The amperometric investigation of MXene-Cu2O composite for the detection of glucose shows a broad linear range (0.01–30 mM) with a sensitivity of 11.061/μAmM cm?2 and a detection limit of 2.83 μM. Further, the fabricated sensor exhibits good selectivity with interfering species like NaCl, fructose, sucrose, urea, ascorbic acid, lactose, short response time, stability, good reproducibility, and compatibility with human serum sample. From the investigation, the prepared MXene-Cu2O composite is a good candidate for the direct detection of glucose molecules and is also well suitable for clinical diagnosis. 相似文献
An efficient and facile protocol for the synthesis of azine and azole ring systems was reported. Whereas, reaction of cinnamoyl isothiocyanate with N-nucleophile containing compounds (namely, p-aminophenol (2), N1-phenylbenzene-1,4-diamine (5) and p-aminoacetophenone (8)) tolerated thiourea derivatives 3, 6, and 9, respectively. The later compounds underwent intramolecular cyclization upon treatment with EtONa to give pyrimidinethiones 4, 7, and 10, respectively, in moderate yield (74–79%). Compound 9 underwent intramolecular cyclization and condensation upon reaction with NaOH and benzaldehyde to give pyrimidinethione 12. Thiosemicarbazides 14 and 19 were obtained through reaction of heteroallen 1 with 2,4-dinitrophenylhydrazine 13 and hydrazone 18, respectively. Compound 14 was cyclized to pyrimidinethione 15 and triazine derivatives 17 through its reaction with EtONa at room temperature and refluxing temperature, respectively. Finally, base mediated and oxidative cyclization of thiourea derivative 19 with EtONa, Br2/AcOH, and Pb(OAc)2 afforded thiadiazole 20, benzothiazolotriazole 21, and triazolethione 22 derivatives, respectively. 相似文献
Molecular Diversity - Transmembrane protease serine-2 (TMPRSS2) is a cell-surface protein expressed by epithelial cells of specific tissues including those in the aerodigestive tract. It helps the... 相似文献
Friedel-Crafts acyl rearrangements in PPA of diacetylpyrenes (80–120 °C), dibenzoylpyrenes (80–200 °C), and bis(4-flurobenzoyl)pyrenes (80–120 °C) and Scholl reactions in AlCl3/NaCl of dibenzoylpyrenes (140–200 °C) have been studied. The substrates were 1-AcPY, 2-AcPY, 1,3-Ac2PY, 1,6-Ac2PY, 1,8-Ac2PY, 2,7-Ac2PY, 1-BzPY, 1,6-Bz2PY, 1,8-Bz2PY, 1-4FBzPY, 1,6-4FBz2PY, 1,8-4FBz2PY. The mixtures of pyrene, 1-AcPY, 2-AcPY, 1,3-Ac2PY, 1,6-Ac2PY, 1,8-Ac2PY, and 2,7-Ac2PY were separated by HPLC. The following reversible intermolecular isomerizations were established: 1,6-Ac2PY ? 1,8-Ac2PY, 1,6-Bz2PY ? 1,8-Bz2PY, and 1,6-4'FBz2PY ? 1,8-4'FBz2PY, albeit not in high yields. The results substantiate Gore’s 1955 proposition that “The Friedel–Crafts acylation reaction of reactive aromatic hydrocarbons is a reversible process.” The isomerizations reported here differ from the few previously reported completely reversible intramolecular Friedel-Crafts acyl rearrangements. At ≥ 140 °C, in PPA and in AlCl3/NaCl, 1,6-Bz2PY and 1,8-Bz2PY underwent a highly regioselective double Scholl reaction to give pyranthrone (3) and deacylations to 1-BzPy (and pyrene), followed by mono-Scholl reactions to give 8H-dibenzo[def,qr]chrysen-8-one (1), and 11H-indeno[2,1-a]pyren-11-one (2). The formation of 3 and not the expected tribenzo[a,ghi,o]perylene-7,16-dione (4) from 1,8-Bz2PY indicates that 1,8-Bz2PY has first undergone isomerization to 1,6-Bz2PY. The present study confirms the linkage between Friedel-Crafts acyl rearrangements and the Scholl reaction.
Minichromosome maintenance complex component 7 (MCM7) is involved in replicative licensing and the synthesis of DNA, and its overexpression is a fascinating biomarker for various cancer types. There is currently no effective agent that can prevent the development of cancer caused by the MCM7 protein. However, on the molecular level, inhibiting MCM7 lowers cancer-related cellular growth. With this purpose, this study screened 452 biogenic compounds extracted from the UEFS Natural Products dataset against MCM protein by using the in silico art of technique. The hit compounds UEFS99, UEFS137, and UEFS428 showed good binding with the MCM7 protein with binding energy values of −9.95, −8.92, and −8.71 kcal/mol, which was comparatively higher than that of the control compound ciprofloxacin (−6.50). The hit (UEFS99) with the minimum binding energy was picked for molecular dynamics (MD) simulation investigation, and it demonstrated stability at 30 ns. Computational prediction of physicochemical property evaluation revealed that these hits are non-toxic and have good drug-likeness features. It is suggested that hit compounds UEFS99, UEFS137, and UEFS428 pave the way for further bench work validation in novel inhibitor development against MCM7 to fight the cancers. 相似文献
Dynamic behaviors of multiwall carbon nanotubes (MWCNTs) with finite length are investigated using an analytical method. Multiple elastic shells and linearized model of van der Waals forces are used for development a comprehensive continuum dynamic model of MWCNTs. By applying Laplace transform, analytical solution for thin and thick MWCNTs under dynamic loading are obtained. Dynamic responses of 3-, 9-, and 11-layer MWCNTs under external pressure shock are examined and accuracy of results are verified by comparison the results with those obtained by numerical methods. Both displacement and stress analysis are performed for layers of MWCNTs and frequencies of oscillations are obtained. Also, effects of axial wave created by external pressure shock are studied in MWCNTs with two-dimensional analyses. Dynamic responses of MWCNTs with initial axial displacement are also proposed and the propagation of the axial wave through the length of tubes is illustrated. Furthermore, wave propagation velocity is found by analysis of time history diagram. 相似文献
In this investigation, the effects of spike as retractable drag and aerodynamic heating reduction into the reentry Earth’s atmosphere for hemispherical body flying at hypersonic flow have been numerically studied. This numerical solution has been carried out for different length, shapes and nose configuration of spike. Additional modifications to the tip of the spike are investigated in order to obtain different bow shocks, including no spike, conical, flat and hemispherical aerodisk mounted. Unsteady compressible 3-D Navier–Stokes equations are solved with k ? ω (SST) turbulence model for a flow over a forward facing spike attached to a heat shield for a free stream Mach number of 6. The obtained numerical results are compared with the experimental ones, and the results shows acceptable verification. This analysis shows that the aerodisk is more effective than aerospike. The designs produced 60 and 15 % reduction in drag and wall temperature responses, respectively. 相似文献
First principles calculations are performed to investigate the structural and electronic properties of MX2 (M = Nb, Pt; X = S, Se) monolayers and their van der Waals (vdW) heterostructures. The dynamical stability of monolayers and vdW heterostructures is confirmed by binding energy and phonon spectra. An indirect band gap nature is found for PtS2 and PtSe2 monolayers while NbS2, NbSe2 and all vdW heterostructures are metals. The intrinsic electronic properties of both NbX2 and PtX2 are well preserved due to weak vdW contact. It is demonstrated that a p-type Schottky contact with a small barrier height is formed at NbX2-PtX2 interface. The zero tunnel barrier and higher potential drop across the interface in these contacts imply large transfer of charge carriers across the interface, making them potential candidates in nanoelectronic device applications. 相似文献
Ketamine is a versatile agent primarily utilized as a dissociative anesthetic, which acts by blocking the excitatory receptor N-methyl-d-aspartate receptor (NMDA). It functions to inhibit the current of both Na+ and K+ voltage-gated channels, thus preventing serotonin and dopamine reuptake. Studies have indicated that administering a single subanesthetic dose of ketamine relieves depression rapidly and that the effect is sustained. For decades antidepressant agents were based on the monoamine theory. Although ketamine may not be the golden antidepressant, it has opened new avenues toward mechanisms involved in the pathology of treatment-resistant depression and achieving rapid antidepressant effects. Thus, preclinical studies focusing on deciphering the molecular mechanisms involved in the antidepressant action of ketamine will assist in the development of a new antidepressant. This review was conducted to elucidate the emerging pathways that can explain the complex dose-dependent mechanisms achieved by administering ketamine to treat major depressive disorders. Special attention was paid to reviewing the literature on hydroxynorketamines, which are ketamine metabolites that have recently attracted attention in the context of depression. 相似文献