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1.
Automotive proton exchange membrane fuel cell stacks need to meet manufacturer specified rated beginning-of-life (BOL) performance before being assembled into vehicles and shipped off to customers. The process of “breaking-in” of a freshly assembled stack is often referred to as “conditioning.” It has become an intensely researched area especially in automotive companies, where imminent commercialization of fuel cell electric vehicles (FCEVs) demands a short, energy- and cost-efficient, and practical conditioning protocol. Significant advances in reducing the conditioning time from 1 to 2 days to as low as 4h or less, in some cases without the use of additional inert gases such as nitrogen, and with minimal use of hydrogen, and specialized test stations will be discussed. 相似文献
2.
Tapasi Chand Laxmikanta Khamari Deepak Chopra Saptarshi Mukherjee Manmohan Kapur 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(43):e202200723
A one-step Rh-catalyzed site-selective ortho-C−H alkynylation of perylene as well as naphthalene mono- and diimides is reported. A single step regioselective access to ortho-C−H alkynylated derivatives of these ryleneimides not only increases the step economy of the ortho-functionalization on these dyes but also provides a quick access route towards highly functionalized dyes that have potential optoelectronic applications. Increased solubility of tetra(triisopropylsilyl)acetylenyl PDIs in organic solvents greatly enhances their utility for further derivatization. 相似文献
3.
4.
Shyam K. Singh Oliver S. Fetzer John B. Hynes Thomas C. Williams 《Journal of heterocyclic chemistry》1991,28(5):1459-1461
Nitration of 2-amino-4-oxo-(3H)-5-trifluoromethylquinazoline is shown to occur exclusively at C6 as determined from an analysis of long range 1H and 19F scalar couplings to ring carbons. Nitration of 2-amino-4-oxo-(3H)-5-fluoroquinazoline is found to occur both at C6 and C8 as evident from an analysis of the 19F and 1H couplings of the ring protons. 相似文献
5.
In quasi-steady operation, convection currents in a Bridgmandevice, used for producing a semi-conductor crystal, createinhomogeneities that may make the crystal unusable. It has oftenbeen suggested that additional forces due to rotation or magnetismmight be efficacious in reducing the segregation of the elementsof the alloy. It has been found that, over a wide range of rotationrates, there is no improvement in performance due to rotationabout the vertical axis. However, numerical results that havebeen obtained previously (Lee & Pearlstein, J. Crys. Growth240, 2002) indicate that, when effects of centrifugal buoyancyare introduced, a substantial reduction in segregation is achieved.In the work reported here, by contrast, in which we extend previouslarge-Rayleigh-number asymptotic analysis to include centrifugalbuoyancy, we find no improvement in radial segregation, butrather increasing segregation with increasing rotation rate. 相似文献
6.
Norton P. Peet Shyam Sunder Robert J. Barbuch Edward W. Huber Ester M. Bargar 《Journal of heterocyclic chemistry》1987,24(6):1531-1535
Treatment of o-nitrobenzenesulfonyl chloride ( 3 ) with 5-aminotetrazole (5-AT) gave [(2-nitrophenyl)-sulfonyl]carbamimidic azide ( 6 ), a ring-opened isomer of the expected N-(1H-tetrazol-5-yl)-2-nitrobenzenesulfonamide ( 4 ). Sulfonylcarbamimidic azide 6 was converted to 2-amino-N-(aminoiminomethyl)benzene-sulfonamide ( 7 ) with ethanolic stannous chloride, and to 3-amino-1,2,4-thiadiazine 1,1-dioxide ( 8 ) with sodium dithionite. Methanesulfonyl chloride ( 9 ) and 5-AT gave 2-(methylsulfonyl)carbamimidic azide ( 10 ), which isomerized to 5-[(methylsulfonyl)amino]-1H-tetrazole ( 11 ) in warm ethanol. Attempted cycloaddition of 2-(phenylsulfonyl)carbamimidic azide ( 13 ) and ethyl vinyl ether led only to alkylated tetrazole products. In addition, other tetrazole-alkylating reactions are described. Isomers produced from these alkylations were differentiated with 13C nmr spectroscopy. 相似文献
7.
Lukman O. Alimi Mram Z. Alyami Santanu Chand Walaa Baslyman Niveen M. Khashab 《Chemical science》2021,12(7):2329
Biologics, such as functional proteins and nucleic acids, have recently dominated the drug market and comprise seven out of the top 10 best-selling drugs. Biologics are usually polar, heat sensitive, membrane impermeable and subject to enzymatic degradation and thus require systemic routes of administration and delivery. Coordination-based delivery vehicles, which include nanosized extended metal–organic frameworks (nMOFs) and discrete coordination cages, have gained a lot of attention because of their remarkable biocompatibility, in vivo stability, on-demand biodegradability, high encapsulation efficiency, easy surface modification and moderate synthetic conditions. Consequently, these systems have been extensively utilized as carriers of biomacromolecules for biomedical applications. This review summarizes the recent applications of nMOFs and coordination cages for protein, CRISPR–Cas9, DNA and RNA delivery. We also highlight the progress and challenges of coordination-based platforms as a promising approach towards clinical biomacromolecule delivery and discuss integral future research directions and applications.SACs can be efficiently used to load biologics such as proteins, CRISPR–Cas9, DNA and RNA and release them on-demand. 相似文献
8.
Substituted 6-ethoxyanilino-5H-benzo[a]phenothiazin-5-ones (3a-f) were synthesized by the cyclocondensation of 2-chloro-3-ethoxyanilino-1,4-naphthoquinones with zinc mercaptides of 2-aminothiophenol in pyridine. The nmr, ir and mass spectral data are presented and discussed. 相似文献
9.
Mingjian Wen Samuel M. Blau Evan Walter Clark Spotte-Smith Shyam Dwaraknath Kristin A. Persson 《Chemical science》2021,12(5):1858
A broad collection of technologies, including e.g. drug metabolism, biofuel combustion, photochemical decontamination of water, and interfacial passivation in energy production/storage systems rely on chemical processes that involve bond-breaking molecular reactions. In this context, a fundamental thermodynamic property of interest is the bond dissociation energy (BDE) which measures the strength of a chemical bond. Fast and accurate prediction of BDEs for arbitrary molecules would lay the groundwork for data-driven projections of complex reaction cascades and hence a deeper understanding of these critical chemical processes and, ultimately, how to reverse design them. In this paper, we propose a chemically inspired graph neural network machine learning model, BonDNet, for the rapid and accurate prediction of BDEs. BonDNet maps the difference between the molecular representations of the reactants and products to the reaction BDE. Because of the use of this difference representation and the introduction of global features, including molecular charge, it is the first machine learning model capable of predicting both homolytic and heterolytic BDEs for molecules of any charge. To test the model, we have constructed a dataset of both homolytic and heterolytic BDEs for neutral and charged (−1 and +1) molecules. BonDNet achieves a mean absolute error (MAE) of 0.022 eV for unseen test data, significantly below chemical accuracy (0.043 eV). Besides the ability to handle complex bond dissociation reactions that no previous model could consider, BonDNet distinguishes itself even in only predicting homolytic BDEs for neutral molecules; it achieves an MAE of 0.020 eV on the PubChem BDE dataset, a 20% improvement over the previous best performing model. We gain additional insight into the model''s predictions by analyzing the patterns in the features representing the molecules and the bond dissociation reactions, which are qualitatively consistent with chemical rules and intuition. BonDNet is just one application of our general approach to representing and learning chemical reactivity, and it could be easily extended to the prediction of other reaction properties in the future.Prediction of bond dissociation energies for charged molecules with a graph neural network enabled by global molecular features and reaction difference features between products and reactants. 相似文献
10.
A simple and accurate method has been developed for the determination of organoisothiocyanates and organoisocyanates based on their quantitative reaction with n-butylamine in dimethylformamide medium to form substituted thioureas and ureas, respectively. The solution is mixed with 6 to 7 times its volume of acetonitrile and an excess of carbon disulphide, which converts the residual amine quantitatively into the corresponding n-butylammonium n-butyl dithiocarbamate. The determination is completed by titrating the resulting dithiocarbamate with iodine monobromide solution in acetonitrile. The end point is detected visually by the yellow color imparted to the solution by the first drop of oxidant solution in excess. The dithiocarbamates are quantitatively oxidized to the corresponding thiuram disulphides. 相似文献