A convenient synthesis of 5‐alkylthio‐3,4‐diarylisoxazoles by palladium‐catalyzed coupling reactions

Palladium‐catalyzed coupling reaction was found effective for rapid access to pharmacologically interesting 3,4‐diarylisoxazoles derivatives as selective COX‐2 inhibitors. Thus, the coupling reaction between 5‐alkylthio‐3‐aryl‐4‐iodoisoxazoles and arylboronic acids afforded the target 5‐alkylthio‐3,4‐diarylisoxazoles in good yields.     

Novel fused 1,2,3-triazolo-benzodiazepine derivatives as potent anticonvulsant agents: design,synthesis, in vivo,and in silico evaluations

Molecular Diversity - A novel series of 1,2,3-triazolo-benzodiazepine derivatives 6a–o has been synthesized and evaluated in vivo for their anticonvulsant activities using by...