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Perumattam John Chakravarty Sarvajit McEnroe Glenn A. Goehring R. Richard Mavunkel Babu Suravajjala Sandhya Smith Whitney W. Chen Baili 《Molecular diversity》1997,3(2):121-128
A simple and general approach to the synthesis of chemical libraries based on a universal anhydride template allows the preparation
of large number of compounds. Various cyclic/acyclic amines, primary/secondary amines, differentially protected bifunctional
amines were used as nucleophiles to react with anhydrides. The free carboxylic acid generated was then coupled with solid-bound
amines. The facile and rapid generation of compounds through this multi-component assembly can be accomplished in a combinatorial
parallel synthesis.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
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