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排序方式: 共有90条查询结果,搜索用时 15 毫秒
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Yukiko Yasuoka Yuichiro Izumi Takashi Fukuyama Haruki Omiya Truyen D. Pham Hideki Inoue Tomomi Oshima Taiga Yamazaki Takayuki Uematsu Noritada Kobayashi Yoshitaka Shimada Yasushi Nagaba Tetsuro Yamashita Masashi Mukoyama Yuichi Sato Susan M. Wall Jeff M. Sands Noriko Takahashi Katsumasa Kawahara Hiroshi Nonoguchi 《Molecules (Basel, Switzerland)》2022,27(3)
Anemia is a major complication of chronic renal failure. To treat this anemia, prolylhydroxylase domain enzyme (PHD) inhibitors as well as erythropoiesis-stimulating agents (ESAs) have been used. Although PHD inhibitors rapidly stimulate erythropoietin (Epo) production, the precise sites of Epo production following the administration of these drugs have not been identified. We developed a novel method for the detection of the Epo protein that employs deglycosylation-coupled Western blotting. With protein deglycosylation, tissue Epo contents can be quantified over an extremely wide range. Using this method, we examined the effects of the PHD inhibitor, Roxadustat (ROX), and severe hypoxia on Epo production in various tissues in rats. We observed that ROX increased Epo mRNA expression in both the kidneys and liver. However, Epo protein was detected in the kidneys but not in the liver. Epo protein was also detected in the salivary glands, spleen, epididymis and ovaries. However, both PHD inhibitors (ROX) and severe hypoxia increased the Epo protein abundance only in the kidneys. These data show that, while Epo is produced in many tissues, PHD inhibitors as well as severe hypoxia regulate Epo production only in the kidneys. 相似文献
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Sands M Haswell SJ Kelly SM Skelton V Morgan DO Styring P Warrington B 《Lab on a chip》2001,1(1):64-65
The paper describes the equilibrium dependant reaction for the formation of enamines in a microchemical system utilising electroosmotic flow (EOF) for fluid mobilisation. The authors have shown that the reaction can be carried out without the presence of a Lewis acid catalyst, in addition the enamine intermediate was synthesised at room temperature using mild solvent conditions. A 42% conversion of cyclohexanone into the enamine has been achieved to date. 相似文献
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We show that every collection ofw sets such that none contains any other generates at least 3w-2 sets under the operations of taking intersections and unions. In particular, we prove that if the finite distributive lattice ? contains an antichain of sizew, then |?| ≧3w, forw≠1, 2, 3, 6, where the minimal exceptional cases arise from the Boolean algebras ?n withn=0, 1, 2, 3, 4 atoms. 相似文献
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Electrodeposition of ordered Bi2Te3 nanowire arrays. 总被引:9,自引:0,他引:9
A L Prieto M S Sander M S Martín-González R Gronsky T Sands A M Stacy 《Journal of the American Chemical Society》2001,123(29):7160-7161