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1.
Let (S,0) be a rational complex surface singularity with reduced fundamental cycle, also known as a minimal singularity. Using a fundamental result of M. Spivakovsky, we explain how to describe the equisingularity type of the discriminant curve for a generic projection of (S,0) onto (C2,0) from the resolution of (S,0). To cite this article: R. Bondil, C. R. Acad. Sci. Paris, Ser. I 337 (2003).  相似文献   
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Using [Cp(Me)5Rh(bipy)C1]C1 (1) as redox catalyst for the continous NADH regeneration it was possible to perform an electrochemically driven enzymatic reduction of pyruvate to D-lactate catalyzed by D-LDH at a rate of 5 turnovers per hour. This is by a factor of 20 faster than the best results obtained until now. Current yields of 50 to 70 % may be obtained.  相似文献   
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Under Friedel-Crafts conditions, meso-tetraarylporphyrins give porphyrin spiro dimers in good yield. This reaction involves acylation, acid-catalyzed cyclization, and dimerization. A stable dimer possessing three additional six-membered rings could be isolated and its structure determined. By modifying the substrate and reagents, intermediates could be isolated and characterized. The reactivity of the substrates, the side-reactions, and the concentration requirements to form the dimers, all explain why this reaction remained apparently unexplored in the widely used meso-tetraarylporphyrin series. [reaction: see text]  相似文献   
6.
Two synthetic approaches to the novel C10H16 hydrocarbon tricyclo[4.4.0.03,9]decane ( 1 ; 2-homotwistbrendane), one of the 19 members of the adamantaneland, and its Lewis-acid-catalyzed rearrangement are described. One route starts from tricyclo[4.3.0.03,8]nonan-2-one ( 2 ; 2-twistbrendanone). The missing tenth C-atom is introduced by ring enlargement (Tiffeneau-Demjanov method). Starting from methyl 8,9,10-trinorborn-5-ene-2-endo-carboxylate ( 8 ), ring enlargement by one C-atom, regio- and stereoselective introduction of a C1 unit to a 2-endo,6-endo-disubstituted bicyclo[3.2.1]octane, and ring closure by acyloin condensation are the key steps in the second approach.  相似文献   
7.
A new heptapode heptakis-6-(5-methylene-thioureido-5′-methyl-2,2′-bipyridyl)-β-cyclodextrin was prepared and its complexation properties towards metal cations were investigated. Substituting the urea functions by the corresponding thioureas promoted the inversion of the metal coordination selectivity. Preliminary results showed the heptapode unable to complex lanthanides but authorise selective complexation of ‘soft’ and ‘borderline’ metal cations.  相似文献   
8.
The synthesis of 2, 7-dioxa-isotwistane ( 10 ), 2, 7-dioxa-twistane ( 17 ), and 2, 8-dioxa-homotwistbrendane ( 36 ) and several of their derivatives is described starting from endo-2-hydroxy-9-oxabicyclo[3.3.1]non-6-ene ( 1 ). The 10O(7)-isotwistane iodide 7 and the corresponding tosylate 15 as well as the 10O(2)-iodide 9 were treated under reaction conditions suitable for molecular rearrangements involving oxonium ions g and i , respectively, by neighbouring group participation leading to 2, 7-dioxa-twistanes and 2, 8-dioxa-homotwistbrendanes, respectively.  相似文献   
9.
We report on the combination of nanodroplet sample preparation, ultra-low-flow nanoLC, high-field asymmetric ion mobility spectrometry (FAIMS), and the latest-generation Orbitrap Eclipse Tribrid mass spectrometer for greatly improved single-cell proteome profiling. FAIMS effectively filtered out singly charged ions for more effective MS analysis of multiply charged peptides, resulting in an average of 1056 protein groups identified from single HeLa cells without MS1-level feature matching. This is 2.3 times more identifications than without FAIMS and a far greater level of proteome coverage for single mammalian cells than has been previously reported for a label-free study. Differential analysis of single microdissected motor neurons and interneurons from human spinal tissue indicated a similar level of proteome coverage, and the two subpopulations of cells were readily differentiated based on single-cell label-free quantification.

The combination of nanodroplet sample preparation, ultra-low-flow nanoLC, high-field asymmetric ion mobility spectrometry (FAIMS) and latest-generation mass spectrometry instrumentation provides dramatically improved single-cell proteome profiling.  相似文献   
10.
A new tripodal α-cyclodextrin having three ureido-bipyridyl tethers symmetrically distributed on its upper rim was prepared in one step by the polymer supported ‘phosphine imide’ reaction in a medium yield. As expected, the highly selective complexation properties towards ‘hard’ and ‘soft’ cations were maintained with regards to the URFT-Cd (upper rim fully tethered) family previously investigated. Its EuIII and TbIII lanthanide complex fluorescence behaviour clearly indicates that a limited number of tethers allow a better bis-heterocyclic antenna self-organisation around the cation leading to enhanced fluorescence properties.  相似文献   
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