Unusual Spirodecane Sesquiterpenes and a Fumagillol Analogue from Cordyceps ophioglossoides

Investigation of the cultured mycelia of Cordyceps ophioglossoides resulted in the isolation and characterization of three new unusual spiro[4.5]decane sesquiterpenes, cordycepol A ( 1 ), cordycepol B ( 2 ), and cordycepol C ( 3 ), and a new fumagillol analogue, cordycol ( 4 ). Their structures were established by spectroscopic means. The cytotoxic activities were also evaluated, compounds 3 and 4 showing their IC₅₀ values in the range of 12–33 μg/ml against HeLa and HepG2 (Table 3). In addition, 3 and 4 were not obviously harmful towards normal liver cell lines LO2, showing IC₅₀ values above 80 μg/ml.     

痫愈胶囊质量标准研究

制定了痫愈胶囊(天麻、僵蚕、黄芪、党参)的质量标准。用显微鉴别法鉴别僵蚕,用薄层色谱法鉴别黄芪、党参,用高效液相色谱法测定天麻素含量。天麻素含量在0.1036~2.072μg范围内呈良好的线性关系,r=0.9997。平均回收率为98.80%,相对标准偏差为0.94%(n=5)。鉴别方法、定量方法可用于该制剂的质量控制。     

相变材料接触熔化的研究

对有关相变材料接触熔化的研究成果进行了全面的综述, 内容包括:封闭空间的接 触熔化、围绕热源的接触熔化、滑动接触熔化、滚动接触熔化、冰的压力熔化、接 触熔化的量级分析与修正、由液体边界层内的热扩散引起的熔化、不连续接触点上 熔化与润滑、固体内部传热的影响、玻璃的软化与接触熔化.     

配合物研究的一种最优化方法

本文从配位平衡出发,从光度法对单核、逐级配位配合物的实验研究入手,导出了包含配合物逐级稳定常数为未知数、体系中各物质初始浓度为已知条件的非线性目标函数。对该目标函数用最优化方法求算出配合物的逐级稳定常数的最优估值,利用光度与组分的浓度关系又求得配合物摩尔吸光系数的估计值。采用本手段以平衡移动法研究了5—磺基水杨酸铁(Ⅲ)配位平衡体系的各级稳定常数与摩尔吸光系数,用等摩尔系列法研究了其第一级稳定常数和摩尔吸光系数,取得了满意的结果。     

Modeling and simulation of polarization errors in Sagnac fiber optic current sensor

Sagnac fiber optic current sensor (S-FOCS) is a kind of optical interferometer based on Sagnac structure, optical polarization states of sensing light wave in Sagnac fiber optic current sensor are limited. However, several factors induce optical polarization error, and non-ideal polarized light waves cause the interference signal crosstalk in sensor, including polarizer, quarter-wave retarder, splice angular, birefringence and so on. With these errors, linearly polarized light wave in PM fiber and circularly polarized light wave in sensing fiber become elliptically polarized light wave, then, nonreciprocal phase shift induced by magnetic field of the current is interrupted by wrong polarization state. To clarify characteristics of optical polarization error in fiber optic current sensor, we analyze the evolution process of random optical polarization state, linear optical polarization state and circular optical polarization state in Sagnac fiber optic current sensor by using Poincare sphere, then, build optical polarization error models by using Jones matrix. Based on models of polarization state in Sagnac fiber optic current sensor, we investigate the influence of several main error factors on optical polarization error characteristics theoretically, including extinction ratio in polarizer, phase delay in quarter-wave retarder, splice angular between quarter-wave retarder and polarization maintaining fiber. Finally, we simulate and quantify nonreciprocal phase shift to be detected in fiber optic current sensor related with optical polarization errors. In the end, we demonstrate S-FOCS in test. The results show that transfer matrix errors are induced by inaccurate polarization properties during polarization state conversion, then, the stability and accuracy of the S-FOCS are affected, and it is important to control the polarization properties at each step of the polarization state conversion precisely.     

超高效液相色谱-串联质谱法测定阿胶中的驴皮源成分

近年来由于驴皮资源短缺,阿胶价格大幅度上涨,市场上出现了大量以马、骡、猪、牛皮等熬制而成的假胶,导致阿胶质量的参差不齐,严重扰乱了市场,急需高效准确的检测方法提升阿胶品质。该研究采用超高效液相色谱-串联质谱技术,建立了阿胶中驴皮源成分的检测方法。样品加水溶解后,于37 ℃下经胰蛋白酶酶解,产生驴源性特征肽段,以0.1%甲酸乙腈溶液和0.1%甲酸水溶液作为流动相进行梯度洗脱,单次分析时间10 min,在电喷雾正离子(ESI⁺)模式下进行多反应监测(MRM),同位素内标法定量。驴源多肽A1、A2在50~1250 μg/L范围内线性关系良好,相关系数(r)均大于0.996,方法定量限(S/N=10)为20 mg/kg,在300、600、900 mg/kg 3个添加水平上驴源多肽A1、A2的回收率范围为103.2%~108.3%,各加标水平平行测定结果的相对标准偏差(RSD)为1.0%~3.0%,完全能够满足实际样品检测需求。对29批不同生产企业的阿胶进行测定,结果表明,不同企业生产的阿胶中驴源多肽A1、A2的含量之和存在差异,含量为0.096%~0.180%,平均值为0.151%,提示驴源多肽A1、A2含量较低的阿胶生产厂家应注重皮源质量,改进生产工艺,以提升产品质量。该方法操作简便,结果可靠,重现性好,可用于阿胶中驴皮源成分的测定。     

超短脉冲通过实际光学系统的时空特性分析

元件的像差和加工装配误差会影响通过其中的超短脉冲的时空特性。在不考虑介质的非线性作用时,基于傅里叶频谱理论并结合光线追迹和衍射理论,发展了一种有效的数值方法仿真超短脉冲通过光学系统的时空传输特性。以一个引入实际误差的2片式聚焦透镜组为例,分析了入射中心波长为800nm,脉冲宽度为30fs的高斯型超短脉冲通过该系统的传输过程,并通过实验测量了该系统在焦点处的脉冲时间宽度和焦斑大小,并与仿真结果进行了比对。结果表明,该方法不仅可以很好地仿真分析实际光学系统中超短脉冲的时空传输效应,也使得超短脉冲系统的优化设计成为可能,同时也为提出加工要求和合理的公差分配提供了指导意义。     

Synthesis and biological evaluation of benzomorpholine derivatives as novel EZH2 inhibitors for anti-non-small cell lung cancer activity

The histone lysine methyltransferase EZH2 has been reported to play important roles in cancer aggressiveness, metastasis and poor prognosis. In this study, a series of benzomorpholine derivatives were synthesized and biologically evaluated as EZH2 inhibitors. The target compounds were obtained in good yields from 3-amino-5-bromo-2-hydroxybenzoic acid via cyclization, Suzuki coupling and amidation as the key steps. A preliminary optimization study led to the discovery of several potent novel EZH2 inhibitors (6b, 6c, 6x and 6y). Moreover, 6y inhibited the A549 and NCI-H1975 cell lines (IC₅₀?=?1.1 µM and 1.1 µM, respectively). Further studies indicated that 6y can reduce EZH2 expression in intact cells and cause cell arrest in the G2/M phase.

     

基于模糊神经网络的结构非模型主动控制

本文将模糊人工神经网络运用到结构的主动控制中，用模糊联想记忆（ＦＡＭ）神经网络作为控制器，对在地震力下的结构振动进行主动控制，控制过程中无须引入结构的运动模型和精确参数。数值仿真的结果表明，该控制系统具有适应能力强，消振迅速且效果良好的特点。