Electrochemical method for producing radionuclide Lu-177 with high specific activity

A modified method for the isolation of radionuclide ¹⁷⁷Lu obtained from a Yb-176 target irradiated with thermal neutrons is proposed. The method consists of the combination of two electrochemical processes— cementation of ytterbium acetate–chloride solution to sodium amalgam and subsequent electrolysis of the ytterbium solution in a separate electrolytic cell without adjusting the solution. The electrochemical setup consisting of two cells gives the purification factor of ¹⁷⁷Lu from ytterbium at a level of 10⁵–10⁶, which allows using ¹⁷⁷Lu of such quality for labeling bioorganic molecules.     

Biological activity of some sulfur- and selenium-containing spiro compounds

Russian Chemical Bulletin - Cytotoxicity to K-562 leukemia cell line of two spiro compounds containing selenium or sulfur atom in their structure were compared....     

Effects of some 5-anilino-1,2,4-thiadiazole derivatives onto leukemic cells

Russian Chemical Bulletin - The antileukemic activities of some thiadiazole derivatives in the forms of hydrochlorides and salicylates have been determined. The insertion of salicylate ion in the...     

Novel bicyclic derivatives of 1,3-selenazine

Bicyclic isoselenoureas (1-selena-3-azaspiro[5.5]undec-2-en-2-ylamines and 3-selena-1-azabicyclo[3.3.1]non-2-ylideneamines) were obtained by intramolecular cyclization of selenoureas leading to 1,3-selenazine ring formation and tested for antioxidant activity.     

Polymeric composites of 1,2,4-thiadiazole: solubility,dissolution and permeability assay

Journal of Thermal Analysis and Calorimetry - The derivative of 1,2,4-thiadiazole (TDZ) can be considered as a perspective agent for the Alzheimer’s disease prevention. Due to a highly...     

Zinc-containing derivatives of 2-aminopyrimidine

A platform containing three anticancer components is proposed. The components are a radioactive ⁶⁹mZn isotope and zinc complexes, where both zinc and ligand exhibit anticancer properties. Two zinc-containing complexes, namely (2-AP)₂ZnCl₂ and (2-AP)₂Zn(Sal)₂ (AP is 2-aminopyrimidine, Sal is salicylate) were synthesized and characterized. Their cytotoxicity with respect to some leukemia cell lines is demonstrated. Their stability in physiological solution and percentage of apoptosis (by flow cytometry) are investigated. Stable complexes of compounds with the isotope ⁶⁹mZn were characterized by TLC and autoradiography.