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Ting R Harwig C auf dem Keller U McCormick S Austin P Overall CM Adam MJ Ruth TJ Perrin DM 《Journal of the American Chemical Society》2008,130(36):12045-12055
The use of a boronic ester as a captor of aqueous [(18)F]-fluoride has been previously suggested as a means of labeling biomolecules in one step for positron emission tomography (PET) imaging. For this approach to be seriously considered, the [(18)F]-labeled trifluoroborate should be humorally stable such that it neither leaches free [(18)F]-fluoride to the bone nor accumulates therein. Herein, we have synthesized a biotinylated boronic ester that is converted to the corresponding trifluoroborate salt in the presence of aqueous [(18)F]-fluoride. In keeping with its in vitro aqueous kinetic stability at pH 7.5, the trifluoroborate appears to clear in vivo quite rapidly to the bladder as the stable trifluoroborate salt with no detectable leaching of free [(18)F]-fluoride to the bone. When this labeled biotin is preincubated with avidin, the pharmacokinetic clearance of the resulting complex is visibly altered. This work validates initial claims that boronic esters are potentially useful as readily labeled precursors to [(18)F]-PET reagents. 相似文献
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Jahn KA Barton DA Kobayashi K Ratinac KR Overall RL Braet F 《Micron (Oxford, England : 1993)》2012,43(5):565-582
Correlative microscopy is the application of two or more distinct microscopy techniques to the same region of a sample, generating complementary morphological, structural and chemical information that exceeds what is possible with any single technique. As a variety of complementary microscopy approaches rather than a specific type of instrument, correlative microscopy has blossomed in recent years as researchers have recognised that it is particularly suited to address the intricate questions of the modern biological sciences. Specialised technical developments in sample preparation, imaging methods, visualisation and data analysis have also accelerated the uptake of correlative approaches. In light of these advances, this critical review takes the reader on a journey through recent developments in, and applications of, correlative microscopy, examining its impact in biomedical research and in the field of plant science. This twin emphasis gives a unique perspective into use of correlative microscopy in fields that often advance independently, and highlights the lessons that can be learned from both fields for the future of this important area of research. 相似文献
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The functional Ito formula, in the form df() = f( + d ) f(),is formulated and proved in the context of a Lie algebra L associatedwith a quantum (non-commutative) stochastic calculus. Here fis an element of the universal enveloping algebra U of L, andf() + d() f() is given a meaning using the coproductstructure of U even though the individual terms of this expressionhave no meaning. The Ito formula is equivalent to a chaoticexpansion formula for f() which is found explicitly. 1991 MathematicsSubject Classification: primary 81S25; secondary 60H05; tertiary18B25. 相似文献
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Bobeldijk I Bouwhuis M Ireland DG de Jager CW Jans E de Jonge N Kasdorp WJ Konijn J Lapikás L van Leeuwe JJ van der Meer RL Nooren GJ Passchier E Schroevers M van der Steenhoven G Steijger JJ Theunissen JA van Uden MA de Vries H de Vries R de Witt Huberts PK Blok HP van den Brink HB Dodge GE Harakeh MN Hesselink WH Kalantar-Nayestanaki N Pellegrino A Spaltro CM Templon JA Hicks RS Kelly JJ Marchand C 《Physical review letters》1994,73(20):2684-2687
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Ab initio SCF perturbation theory calculations have been performed for the contact, orbital and dipolar contributions to the nuclear spin—spin coupling constants in A1H3, SiH4 PH3, H2S and HCl, using large, stable gaussian basis sets. The results for J(XH) are in reasonably good agreement with experiment, those for. J(HH) are rather less good. 相似文献
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van den Brink HB Blok HP Bobeldijk I Bouwhuis M Dodge GE Harakeh MN Hesselink WH Ireland DG de Jager CW Jans E de Jonge N Kalantar-Nayestanaki N Kasdorp WJ Ketel TJ Konijn J Lapikás L van Leeuwe JJ van der Meer RL Nooren GJ Norum BE Passchier E Pellegrino AR Spaltro CM van der Steenhoven G Steijger JJ Templon JA Theunissen JA van Uden MA de Vries H de Vries R de Witt Huberts PK 《Physical review letters》1995,74(18):3561-3564
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