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Irina Ielciu Mihaela Niculae Emoke Pall Cristina Barblat Ioan Tomu Neli-Kinga Olah Ramona Flavia Burtescu Daniela Benedec Ilioara Oniga Daniela Hanganu 《Molecules (Basel, Switzerland)》2022,27(13)
Rosmarinus officinalis L. is a species that is widely known for its culinary and medicinal uses. The purpose of the present study consisted of the evaluation of the antiproliferative and antimicrobial effects of R. officinalis-loaded liposomes (L-R). Characterization of the liposomes was performed by establishing specific parameters. The load of the obtained liposomes was analyzed using an LC-MS method, and antiproliferative assays evaluated the cell viability on a liver adenocarcinoma cell line and on a human hepatic stellate cell line. Antimicrobial assays were performed by agar–well diffusion and by broth microdilution assays. The obtained liposomes showed high encapsulation efficiency, suitable particle size, and good stability. High amounts of caffeic (81.07 ± 0.76), chlorogenic (14.10 ± 0.12), carnosic (20.03 ± 0.16), rosmarinic (39.81 ± 0.35), and ellagic (880.02 ± 0.14) acids were found in their composition, together with other polyphenols. Viability and apoptosis assays showed an intense effect on the cancerous cell line and a totally different pattern on the normal cells, indicating a selective toxicity towards the cancerous ones and an anti-proliferative mechanism. Antimicrobial potential was noticed against all tested bacteria, with a better efficacy towards Gram-positive species. These results further confirm the biological activities of R. officinalis leaf extract, and proposes and characterizes novel delivery systems for their encapsulation, enhancing the biological activities of polyphenols, and overcoming their limitations. 相似文献
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We investigate collisions between solitons in a lossless two-channel wavelength-division multiplexed system with strong dispersion management. Numerical results show that the net frequency shift that is due to interchannel collisions is at least 1 order of magnitude smaller than predicted by adiabatic theories. A modified theoretical analysis is presented and shown to be in good agreement with the numerical results. 相似文献
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We present analytical and numerical results for the amount of timing-jitter reduction obtained in an all-optical clock-recovery device in which a data stream is used to mode lock a fiber laser through cross-phase modulation. This situation is analyzed when the laser pulses are close to optical solitons, so the effect of the data stream on the laser pulses is predicted from soliton perturbation theory. In our numerical simulations, both periodic input and pseudorandom input data streams are considered. The results show that for both types of data the rms timing jitter in the recovered clock is reduced significantly from that present in the input data. 相似文献
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We show that collision-induced frequency shifts in wavelength-division-multiplexed (WDM) soliton transmission systems are strongly suppressed with increasing dispersion management. We predict new oscillations in the residual frequency shift response, owing to the relative motion induced by the dispersion map, and demonstrate a direct correlation between these oscillations and the modified soliton-collision dynamics. Simple analytical expressions for the oscillation minima are obtained, and implications for WDM soliton system design are discussed. 相似文献
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Vasile A. Popescu Niculae Tiberiu Puscas Guido Perrone 《The European Physical Journal D - Atomic, Molecular, Optical and Plasma Physics》2014,68(8):1-8
We report experimental research of the laser-produced indium plasma in hydrogen, argon and residual atmospheric ambient conditions. Note on general plasma behavior and morphology is presented. On the basis of intensity ratio of the two intense neutral resonance spectral lines (In I 410.2 nm and 451.1 nm), self-absorption was found to be almost negligible in case of argon environment at a pressure of 6650 Pa. Under these conditions, the first Stark widths (W) and shifts (d) measurements were performed as well. The resulting synthetic Lorentz profiles, based on the hyperfine structure of these two lines and corresponded W values, were calculated in order to reproduce measured W m in case of particular electron temperature (T) and number density (N). These results should be of interest to the upcoming theoretical calculations concerning neutral indium spectral lines and also for various diagnostic applications. 相似文献
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Gabriela?Niculae Ioana?Lacatusu Nicoleta?Badea Aurelia?Meghea Raluca?StanEmail author 《Central European Journal of Chemistry》2014,12(8):837-850
Due to their unique features, most nanostructured lipid carriers (NLCs) in association with vegetable oils that exhibit UV filtering properties and bioactivity could be used in many cosmetic formulations. Therefore, in this work, a new application of pomegranate seed oil (PSO) in the cosmetic sector was developed, based on the synthesis of bioactive lipid nanocarriers loaded with various UV filters by the hot high pressure homogenization technique. To get broad spectrum photoprotection, different UVA and UVB filters have been used (Avobenzone — AVO, Octocrylen-OCT, Bemotrizinol — BEMT). The influence of the solid lipids combined with PSO on the particle size, physical stability and entrapment efficiency was investigated using 8 nanocarrier systems. An improved physical stability and an appropriate size were obtained for NLCs prepared with Emulgade, carnauba wax and PSO (e.g. ?30.9÷-36.9 mV and 160÷185 nm). NLCs showed an entrapment efficiency above 90% and assured slow release rates of UV filters, especially for BEMT (5%). The developed nanocarriers have been formulated into safe and effective sunscreens containing low amounts of synthetic UV filters coupled with a high percent of natural ingredients. The highest SPF of 34.3 was obtained for a cream comprising of 11% PSO and 3.7% BEMT 相似文献
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The aim of this study was to develop some sunscreen formulations able to maintain their photoprotection when exposed to UV radiation. In this context, the influence of the antioxidant α-tocopherol on the photostability of lipid-based nanoparticles, namely solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs), encapsulated with a UVA filter, has been investigated. The nanoparticles co-encapsulated with both actives exhibited dimensions smaller than 200 nm and zeta potentials of –45 mV. The photoprotection of the creams based on lipid nanoparticles was evaluated in terms of two protection factors, SPF and erythemal UVA–PF. By exposing the creams to UV radiation, it was observed that tocopherol results in obtaining quite stable formulations, but it does not improve the overall photoprotection much. However, by adding the antioxidant to the formulation confers a double action: protection of the skin against reactive oxygen species and the photostabilization of the UVA filter into lipid nanoparticles. 相似文献
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We construct a second order elliptic equation in divergence form in3, with a nonzero solution which vanishes in a half-space.The coefficients are -Hölder continuous of any order < 1. This improves a previous counterexample of Miller (1972, 1974).Moreover, we obtain coefficients which belong to a finer class ofsmoothness, expressed in terms of the modulus of continuity. 相似文献
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In this paper, we report some experimental results concerning several types of loss measurements of Er3+:Ti:LiNbO3 optical waveguides by using optical methods. Using the Fabry-Pérot interferometry method, we evaluated the attenuation coefficient
of an optical waveguide resonator for a laser radiation having λ = 1.55 μm. We also evaluated the insertion losses, polarization dependent losses, and coupling with external losses. Additionally,
from the transmitted spectra of the symmetrical monomode Fabry-Pérot optical waveguide resonator, we were able to evaluate
the value of the group effective refractive index. 相似文献