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1.
Ryoichi Kizu Naoki Otsuki Yoshiko Kishida Akira Toriba Atsushi Mizokami Kerry L Burnstein Carolyn M Klinge Kazuichi Hayakawai 《Analytical sciences》2004,20(1):55-59
We developed a new mammalian cell-based luciferase reporter gene assay for androgenic and antiandrogenic activities of chemicals and environmental samples. Environmental samples usually have a complex matrix that may contain the constituents acting as androgen receptor (AR) agonists, AR antagonists or aryl hydrocarbon receptor (AhR) agonists. AhR agonists are known to elicit the antiandrogenic effect through cross-talk between AR and AhR signal transduction pathways. In this study, PC3/AR human prostate carcinoma cells were transiently transfected with a prostate-specific antigen (PSA) promoter-driven luciferase expression plasmid. The cells were treated with a test compound or an environmental sample for 24 h at 37 degrees C and then measured for luciferase activity. The luciferase activity was induced by dihydrotestosterone (DHT) in a concentration-dependent manner in a concentration range from 10 fM to 1 nM. R1881, a synthetic androgen receptor agonist, induced luciferase activity and its inductive effects was additive to that of DHT. The luciferase activity was not induced by cortisol, a glucocorticoid, progesterone, a progestin, and 17beta-estradiol, an estrogen in a concentration range of up to 1 microM. DHT-induced luciferase activity was reduced by bicalutamide and cyproterone acetate, AR antagonists, and also by benzo[a]pyrene, an aryl hydrocarbon receptor agonist, through AhR-mediated pathways. All of these findings indicate that the present assay system correctly responds to AR agonists, AR antagonists and AhR agonist and, therefore, it is a powerful tool for the sensitive and selective screening of chemicals and environmental samples for their androgenic and antiandrogenic activities. We developed the first assay system, in which the expression of luciferase was driven by the promoter of a prostate-specific antigen gene, a typical human androgen-regulated gene. 相似文献
2.
S.N. Abdulmadjid M.M. Suliyanti K.H. Kurniawan T.J. Lie M. Pardede R. Hedwig K. Kagawa M.O. Tjia 《Applied physics. B, Lasers and optics》2006,82(1):161-166
We report in this paper the results of an experimental study on hydrogen analysis of solid samples in high pressure helium
ambient gas employing the basic scheme of laser induced breakdown spectroscopy (LIBS). It is shown that the metastable excited
state of helium atom can be utilized to induce delayed excitation of the ablated hydrogen atoms, and thereby avoid the Stark
broadening effect as well as overcoming the undesirable mismatch effect, which are responsible for inefficient excitation
respectively. It is further demonstrated that for samples of high boiling-point materials such as zircaloy, successful hydrogen
analysis can be achieved by a newly introduced double excitation technique employing single laser realized in a modified configuration
of the conventional LIBS method.
PACS 51-52 相似文献
3.
Naoki Miyamoto Shusuke Nisiyama Satoshi Tomioka Takeaki Enoto 《Optics Communications》2007,272(1):67-72
We utilize nitroanisole, that absorbs infrared (IR) radiation as heat, as an optical modulation device based on a thermal process. The nitroanisole exhibits a thermal lens effect, i.e. a temperature dependent refractive index. Hence, the nitroanisole can induce phase modulation to visible light, in direct response to intensity of the incident IR radiation. The proposed method can be used to obtain the phase modulation distribution that corresponds to the IR intensity distribution, i.e. the IR hologram itself, on the nitroanisole by examining the phase map of visible light that is modulated upon passing through the nitroanisole. The IR wavefront can be reconstructed by calculating extracted IR holograms through the Fresnel transform. It is verified that both the amplitude and the phase of the IR wavefront can be reconstructed accurately by proposed method. 相似文献
4.
5.
Nahoko Yamaji Manabu Horikawa Hideo Naoki Terumi Nakajima 《Tetrahedron letters》2004,45(28):5371-5373
A novel polyamine toxin, named MG30, was isolated from the venom of the spider, Macrothele gigas, and its structure was elucidated by two-dimensional NMR and mass analysis. In addition, the enantioselective synthesis of MG30 was achieved to assign its absolute stereochemistry. 相似文献
6.
Naoki Murabayashi 《Journal of Number Theory》2004,108(2):268-286
The purpose of this paper is to decide the conditions under which a CM elliptic curve is modular over its field of definition. 相似文献
7.
8.
The simultaneous removal of NO? and soot particulates in an oxidizing atmosphere is desirable for the aftertreatment of diesel exhausts. After briefly reviewing the development of catalysts for reactions involving carbons, our recent studies on the simultaneous NO?–soot removal using perovskite-related and spinel-type oxides are described. 相似文献
9.
Masafumi Unno Hiroyuki Murakami Satoshi Kagawa Hideyuki Matsumoto 《Silicon Chemistry》2007,3(3-4):195-198
Two new silanols bearing very bulky silyl groups, (i-Pr3
Si)3SiOH and (t − BuMe2Si)3SiOH were prepared by peracidoxidation of their respective silanes. The X − ray crystallographic analysis revealed that (t − BuMe2Si)3 SiOH forms a dimeric structure with hydrogen bonding, while (i − Pr3 Si)3 SiOH exists as a monomer in the crystal. The effects of the size of the substituents as well as the reactivity of these silanols
are discussed. 相似文献
10.
A potentiometric and spectrophotometric investigation on the formation of zinc(II) complexes with Semi-Xylenol Orange (SXO or H(4)L) is reported. In an aqueous solution (mu = 0.1), three 1:1 complex species, MH(2)L, MHL(-), ML(2-), and a 1:2 complex, ML(6-)(2), seem to exist. In a strongly alkaline medium (above pH 12.5) the complexes may dissociate to give zinc hydroxide and L(4-). The formation of a hydroxy complex is not observed. The absorption maxima are at 445 nm (MH(2)L), 466 nm (MHL(-)) and 561 nm (ML(2-)), the molar absorptivities being 2.34 x 10(4), 2.42 x 10(4) and 3.14 x 10(4) 1.mole(-1) .cm(-1) respectively. The formation constants are (at 25 +/- 0.1 degrees ) log K(M)(ML) = 11.84, log K(M)(MHL) = 7.13, log K(M)(MH(2)L) = 2.70, log K(M)(ML(2)) = 16.60. 相似文献