排序方式: 共有12条查询结果,搜索用时 15 毫秒
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Hosseini Fahimeh Mohammadi-Khanaposhtani Maryam Azizian Homa Ramazani Ali Tehrani Maliheh Barazandeh Nadri Hamid Larijani Bagher Biglar Mahmoud Adibi Hossein Mahdavi Mohammad 《Structural chemistry》2020,31(3):999-1012
Structural Chemistry - A new series of 4-oxobenzo[d]1,2,3-triazin-pyridinium-phenylacetamide hybrids 8a–p was designed, synthesized, and screened as the potential cholinesterase inhibitors... 相似文献
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Tashrifi Zahra Mohammadi-Khanaposhtani Mohammad Hamedifar Haleh Larijani Bagher Ansari Samira Mahdavi Mohammad 《Molecular diversity》2020,24(4):1385-1431
Molecular Diversity - 2-Amino-3-cyano-4H-chromenes are structural core motifs that received increasing attention in the last years due to their interesting potential pharmacological properties. In... 相似文献
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Mohammad S. Asgari Behnam Tahmasebi Somayeh Mojtabavi Mohammad A. Faramarzi Rahmatollah Rahimi Parviz R. Ranjbar Mahmood Biglar Bagher Larijani Hossein Rastegar Maryam Mohammadi-Khanaposhtani Mohammad Mahdavi 《Journal of heterocyclic chemistry》2020,57(12):4348-4357
A new series of acridine-9-carboxamide-1,2,3-triazole derivatives 7a-m were designed, synthesized, and evaluated as novel α-glucosidase inhibitors. Acridine-9-carboxamide-1,2,3-triazole scaffold has been designed by combination of effective moieties from potent α-glucosidase inhibitors. Most of the synthesized compounds were more potent than standard inhibitor acarbose. Among the title compounds, the most potent compounds were compounds 7j , 7k , and 7a with IC50 values of 120.2 ± 1.0, 151.1 ± 1.4, and 157.6 ± 1.6 μM, respectively (IC50 value of acarbose = 750.0 ± 10.0 μM). Docking study of the most potent compounds demonstrated that these compounds formed stable complexes with α-glucosidase active site. Anti-α-amylase assay of compounds 7j , 7k , and 7a was performed and no activity was observed. in vitro cytotoxicity assay of the latter compounds revealed that these compounds were not cytotoxic toward human normal (HDF) and cancer (MCF-7) cell lines. ADME and toxicity prediction of compounds 7j , 7k , and 7a were also performed. 相似文献
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Ramandi Monireh Riahi Siavash Rahimi Hamzeh Mohammadi-Khanaposhtani Mohammad 《Structural chemistry》2020,31(5):2023-2040
Structural Chemistry - Factor Xa (FXa) enzyme has an important role in the blood coagulation system. Disruption in the enzyme function results in the production of blood clots. Therefore,... 相似文献
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Tashrifi Zahra Mohammadi-Khanaposhtani Mohammad Larijani Bagher Hamedifar Halleh Ansari Samira Mahdavi Mohammad 《Molecular diversity》2021,25(4):2533-2570
Molecular Diversity - Nowadays, application of vinylazides as precursors is a key method for the construction of N-heterocycles in organic synthesis. These versatile three-atom synthons can be... 相似文献
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Esfahani Ensieh Nasli Mohammadi-Khanaposhtani Maryam Rezaei Zahra Valizadeh Yosef Rajabnia Ramazan Hassankalhori Mahdi Bandarian Fatemeh Faramarzi Mohammad Ali Samadi Nasrin Amini Mohammad Reza Mahdavi Mohammad Larijani Bagher 《Research on Chemical Intermediates》2019,45(2):223-236
Research on Chemical Intermediates - We designed and synthesized a series of new ciprofloxacin–dithiocarbamate–benzyl hybrids 5a–n as potential antibacterial agents. All of the... 相似文献
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Sedaghati Saeb Azizian Homa Montazer Mohammad Nazari Mohammadi-Khanaposhtani Maryam Asadi Mehdi Moradkhani Fatemeh Ardestani Mehdi Shafiee Asgari Mohammad Sadegh Yahya-Meymandi Azadeh Biglar Mahmood Larijani Bagher Sadat-Ebrahimi Seyed Esmaeil Foroumadi Alireza Amanlou Massoud Mahdavi Mohammad 《Structural chemistry》2021,32(1):37-48
Structural Chemistry - A novel series of (thio)barbituric-phenoxy-N-phenylacetamide derivatives 7a-l was synthesized and evaluated against Helicobacter pylori urease. The latter assay revealed that... 相似文献
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Maryam Mohammadi-Khanaposhtani Hoda Yahyavi Somaye Imanparast Fereshte Nazemi Harandi Mohammad Ali Faramarzi Alireza Foroumadi Bagher Larijani Mahmood Biglar Mohammad Mahdavi 《中国化学会会志》2020,67(5):856-863
Benzoylquinazolinone derivatives 3a–n were synthesized via a simple one-step reaction, and evaluated for in vitro α-glucosidase inhibitory activity. Compounds 3d , 3f–g , 3i , and 3m–n showed more inhibitory activity than standard drug acarbose (IC50 = 750.0 ± 1.5 μM), and among them, compound 3d displayed the highest α-glucosidase inhibitory activity (IC50 = 261.6 ± 0.1 μM). The kinetic analysis of the compound 3d revealed that this compound inhibited α-glucosidase in a competitive manner (Ki = 255 μM). The docking studies were applied to predict binding modes of the synthesized compounds in active site of α-glucosidase. 相似文献
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Peytam Fariba Adib Mehdi Shourgeshty Reihaneh Mohammadi-Khanaposhtani Maryam Jahani Mehdi Imanparast Somaye Faramarzi Mohammad Ali Mahdavi Mohammad Moghadamnia Ali Akbar Rastegar Hossein Larijani Bagher 《Molecular diversity》2020,24(1):69-80
Molecular Diversity - A new series of imidazo[1,2-b]pyrazole derivatives 4a–o was designed, synthesized, and screened for in vitro α-glucosidase inhibitory activity. All compounds showed... 相似文献