Broken Ergodicity in Classically Chaotic Spin Systems

A one dimensional classically chaotic spin chain with asymmetric coupling and two different inter-spin interactions, nearest neighbors and all-to-all, has been considered. Depending on the interaction range, dynamical properties such as ergodicity and chaoticity are very different. Indeed, even in the presence of chaoticity, the model displays a lack of ergodicity only in presence of all to all interaction and below an energy threshold, that persists in the thermodynamical limit. The energy threshold can be found analytically and results can be generalized for a generic XY model with asymmetric coupling.     

Hybrid aminoglycoside antibiotics via Tsuji palladium-catalyzed allylic deoxygenation

Biosynthetically inspired manipulation of the antibiotic paromomycin led, in six high-yielding steps, to a ring A harboring an α,β-unsaturated 6'-aldehyde and an allylic 3'-methylcarbonate group. Tsuji deoxygenation in the presence of 5 mol % Pd(2)(dba)(3) and Bu(3)P granted access to a novel series of 3',4'-dideoxy-4',5'-dehydro ring A hybrids. The neomycin-sisomicin hybrid exhibited superior in vitro antibacterial activity to the parent compound neomycin.