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The site of proton abstraction by OH? ion in some 4-substituted-3,5,6-triphenyl-Δ′-cyclohexenes has been established from labelling studies. The further fragmentation mode of (M-H)? ion depends on its structure and stereochemistry. The and nitro isomers exhibit stereochemical differences in the elimination of HNO2 while the amino and cyano analogues show stereochemically controlled RDA fragmentation mode. 相似文献
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Pradeep Savitha Devaswamparambil Sebastian Deepa Gopalakrishnan Anjali Krishna Manoharan Divya Kizhakkeppurath Madhusudhanan Dhanya Thaikatt Mohanan Puzhavoorparambil V. 《Journal of fluorescence》2021,31(4):1113-1123
Journal of Fluorescence - A heterocyclic Schiff base (MPDPI)was synthesized by the condensation reaction of 1-phenylisatin with 4,5-dimethylphenylene diamine. It was characterized by using... 相似文献
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Dr. Subhrajyoti Bhandary Dr. Atchutarao Pathigoolla Mithun C. Madhusudhanan Prof. Dr. Kana M. Sureshan 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(28):e202200820
A new class of attractive intermolecular interaction between azide and ethynyl structural entities in a wide range of molecular crystals is reported. This interaction was systematically evaluated by using 11 geometrically different structural motifs that are preorganized to direct a solid-state topochemical azide–alkyne cycloaddition (TAAC) reaction. The supramolecular features of the azide–alkyne interaction were mapped by various crystallographic and quantum chemical approaches. Topological analysis shows the noticeable participation of electron density in the azide⋅⋅⋅alkyne interactions. Interestingly, reorientation of the atomic polarizabilities in vicinal azide and alkyne groups upon interaction in crystals favors soft orbital-guided TAAC reactions. Moreover, various solid-state and gas-phase energy decomposition methods of individual azide⋅⋅⋅alkyne interactions summarize that the strength (varies from −5.7 to −30.1 kJ mol−1) is primarily guided by the dispersion forces with a influencing contribution from the electrostatics. 相似文献
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K.G. Das A. Mahender Reddy M. Vairamani K.P. Madhusudhanan D. Fraisse J.C. Tabet 《Tetrahedron》1984,40(20):4085-4088
The unsaturated dicarboxylates (III and IV) form stable (M+N2H7)+ adducts in addition to the (M+NH4)+ adduct. At high ammonia pressure in the ion source, bimolecular reactions between (M+NH4)+ (M+N2H7) adducts and NH3 result in the reduction of olefinic bonds in unsaturated and dicarboxylates. Evidence was obtained from MIKE/CAD data on the possible structure of the product ion. 相似文献
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Raja Mohanrao Ruth Manorama Shubhra Ganguli Mithun C. Madhusudhanan Rashna Bhandari Kana M. Sureshan 《Molecules (Basel, Switzerland)》2021,26(12)
IP6K and PPIP5K are two kinases involved in the synthesis of inositol pyrophosphates. Synthetic analogs or mimics are necessary to understand the substrate specificity of these enzymes and to find molecules that can alter inositol pyrophosphate synthesis. In this context, we synthesized four scyllo-inositol polyphosphates—scyllo-IP5, scyllo-IP6, scyllo-IP7 and Bz-scyllo-IP5—from myo-inositol and studied their activity as substrates for mouse IP6K1 and the catalytic domain of VIP1, the budding yeast variant of PPIP5K. We incubated these scyllo-inositol polyphosphates with these kinases and ATP as the phosphate donor. We tracked enzyme activity by measuring the amount of radiolabeled scyllo-inositol pyrophosphate product formed and the amount of ATP consumed. All scyllo-inositol polyphosphates are substrates for both the kinases but they are weaker than the corresponding myo-inositol phosphate. Our study reveals the importance of axial-hydroxyl/phosphate for IP6K1 substrate recognition. We found that all these derivatives enhance the ATPase activity of VIP1. We found very weak ligand-induced ATPase activity for IP6K1. Benzoyl-scyllo-IP5 was the most potent ligand to induce IP6K1 ATPase activity despite being a weak substrate. This compound could have potential as a competitive inhibitor. 相似文献
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