Drug repositioning for anti-tuberculosis drugs: an in silico polypharmacology approach

Molecular Diversity - Development of potential antitubercular molecules is a challenging task due to the rapidly emerging drug-resistant strains of Mycobacterium tuberculosis (M.tb)....     

Hydrogenation of acetophenone over bifunctional multi metal oxide catalysts

The vapor phase hydrogenation of acetophenone at atmospheric pressure is carried out for the synthesis of 1-phenylethanol in a fixed bed reactor using Cu-Zn-Al-O (LTS-1) and LTS-2, Zn-Cr-Al-O (HTS-1) and Zn-Cu-Cr-Al-O (HTS-2) metal oxide catalysts. Our studies clearly indicate that a catalyst of low temperature hydrogenation activity, when modified for its acidity with magnesium oxide, shows maximum selectivity of 1-phenylethanol. This revised version was published online in June 2006 with corrections to the Cover Date.     

Short-Lived Radical Intermediates in the Photochemistry of Glucose Oxidase

Glucose oxidase is a flavoprotein that is relatively well-studied as a physico-chemical model system. The flavin cofactor is surrounded by several aromatic acid residues that can act as direct and indirect electron donors to photoexcited flavin. Yet, the identity of the photochemical product states is not well established. We present a detailed full spectral reinvestigation of this issue using femtosecond fluorescence and absorption spectroscopy. Based on a recent characterization of the unstable tyrosine cation radical TyrOH^•+, we now propose that the primary photoproduct involves this species, which was previously not considered. Formation of this product is followed by competing charge recombination and radical pair stabilization reactions that involve proton transfer and radical transfer to tryptophan. A minimal kinetic model is proposed, including a fraction of TyrOH^.+ that is stabilized up to the tens of picoseconds timescale, suggesting a potential role of this species as intermediate in biochemical electron transfer reactions.