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排序方式: 共有49条查询结果,搜索用时 171 毫秒
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A. J. Blotcky E. P. Rack R. R. Recker J. A. Leffler S. Teitelbaum 《Journal of Radioanalytical and Nuclear Chemistry》1978,43(2):381-388
A destructive neutron activation analysis procedure was developed for determining trace aluminum content in bone. It was found
that soil contamination can influence the aluninum bone levels in prehistoric bone specimens. These maximum aluninum content
values for prehistoric bone are larger than those of modern bone and comparable to aluminum levels present in bone from renal
patients. 相似文献
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Medzihradszky KF Leffler H Baldwin MA Burlingame AL 《Journal of the American Society for Mass Spectrometry》2001,12(2):215-221
A biologically active protein fraction was isolated from rabbit intestine, purified by one-dimensional SDS-PAGE and stained with Coomassie Brilliant Blue. A predominant band of approximately 110-130 kDa was excised and digested in-gel with trypsin. The resulting peptides were extracted then separated by microbore reversed-phase high-performance liquid chromatography (HPLC). Mass spectrometric data from one HPLC fraction obtained by two different ionization techniques proved to be complementary. Matrix-assisted laser desorption/ionization (MALDI) showed nine peptide masses, which by post source decay analysis and database searching were attributed to two proteins. Nanoflow electrospray analysis performed on a hybrid tandem mass spectrometer of quadrupole-quadrupole-orthogonal acceleration time-of-flight (QqTOF) geometry detected six additional peptide components. On the basis of the additional peptides and superior quality collision-induced dissociation spectra typical of this instrument type, two further proteins were identified. The resolution afforded by the QqTOF instrument permitted charge state determination for the fragment ions while preserving the high detection sensitivity that was essential in obtaining the composition of this mixture of proteins. 相似文献
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Nernst R Antreasyan D Aschman D Besset D Bienlein JK Bloom ED Brock I Cabenda R Cartacci A Cavalli-Sforza M Clare R Conforto G Cooper S Cowan R Coyne D de Judicibus D Edwards C Engler A Folger G Fridman A Gaiser J Gelphman D Godfrey G Heimlich FH Hofstadter R Irion J Jakubowski Z Keh S Kilian H Kirkbride I Kloiber T Koch W König AC Königsmann K Kraemer RW Lee R Leffler S Lekebusch R Lezoch P Litke AM Lockman W Lowe S Lurz B Marlow D Maschmann W Matsui T Messing F Metzger WJ Monteleoni B 《Physical review letters》1985,54(20):2195-2198
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Gabriella Kervefors Kumar Bhaskar Pal Gergely L. Tolnai Mukul Mahanti Hakon Leffler Ulf J. Nilsson Berit Olofsson 《Helvetica chimica acta》2021,104(2):e2000220
β-Galactose derivatives have recently been reported to selectively inhibit galectin-3, and a library of O3-arylated galactosides with varying substitution patterns was designed to study such inhibitions further. The O3-arylated galactosides were synthesized using diaryliodonium salts under mild and transition metal free conditions, providing the target products in moderate to good yields. An O3-trifluoroethylated galactoside was also synthesized using iodonium salt chemistry. Azido-substituted products were subsequently transformed into the corresponding triazoles. After deprotection, a selection of galactoside derivatives were evaluated for inhibitory potencies against galectins-1, 3, 4 N (N-terminal domain), 4 C (C-terminal domain), 7, 8 N, 8 C, 9 N, and 9 C and one compound with promising affinity and selectivity for both the N- and C-terminal domain of galectin-9 was discovered. 相似文献
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We study the recovery conditions of weighted mixed $\ell_2/\ell_p$ minimization for block sparse signal reconstruction from compressed measurements when partial block support information is available. We show theoretically that the extended block restricted isometry property can ensure robust recovery when the data fidelity constraint is expressed in terms of an $\ell_q$ norm of the residual error, thus establishing a setting wherein we are not restricted to Gaussian measurement noise. We illustrate the results with a series of numerical experiments. 相似文献