Differential inhibition of postnatal brain,spinal cord and body growth by a growth hormone antagonist

Background  

Growth hormone (GH) plays an incompletely understood role in the development of the central nervous system (CNS). In this study, we use transgenic mice expressing a growth hormone antagonist (GHA) to explore the role of GH in regulating postnatal brain, spinal cord and body growth into adulthood. The GHA transgene encodes a protein that inhibits the binding of GH to its receptor, specifically antagonizing the trophic effects of endogenous GH.     

Quantum adiabatic algorithm and scaling of gaps at first-order quantum phase transitions

Motivated by the quantum adiabatic algorithm (QAA), we consider the scaling of the Hamiltonian gap at quantum first-order transitions, generally expected to be exponentially small in the size of the system. However, we show that a quantum antiferromagnetic Ising chain in a staggered field can exhibit a first-order transition with only an algebraically small gap. In addition, we construct a simple classical translationally invariant one-dimensional Hamiltonian containing nearest-neighbor interactions only, which exhibits an exponential gap at a thermodynamic quantum first-order transition of essentially topological origin. This establishes that (i)?the QAA can be successful even across first-order transitions but also that (ii)?it can fail on exceedingly simple problems readily solved by inspection, or by classical annealing.     

Melt‐spun Eu8Ga16–xGe30+x Clathrates

Intermetallic clathrates are promising materials for thermoelectric applications. This is not only due to their low thermal and high electrical conductivities (“phonon glass – electron crystal”) but also due to the expectation that they are semiconductors and thus have large thermopower values. Band structure calculations of the stoichiometric compound Eu₈Ga₁₆Ge₃₀ indeed yield a semiconducting ground state. However, with conventional synthesis methods the exact 8:16:30 stoichiometry could not be reached. Herein we use the melt‐spinning technique to obtain Eu₈Ga_16–xGe_30+x samples with smaller x than previously realized. The quenching procedure and the results of the characterization of the quenched phases by X‐ray powder diffraction and electron microscopy are presented. The electrical resistivity shows that, in contrast to conventional synthesis procedures, semiconducting compounds can be produced.     

Fusion around the barrier for 7Li+12C

Fusion cross-sections for the ⁷Li + ¹²C reaction have been measured at energies above the Coulomb barrier by the direct detection of evaporation residues. The heavy evaporation residues with energies below 3 MeV could not be separated out from the α-particles in the spectrum and hence their contribution was estimated using statistical model calculations. The present work indicates that suppression of fusion cross-sections due to the breakup of ⁷Li may not be significant for ⁷Li + ¹²C reaction at energies around the barrier.     

Detection of human and rodent 5-HT3B receptor subunits by anti-peptide polyclonal antibodies

Background  

The 5-HT₃ receptor is a member of a neurotransmitter-gated ion channel family which includes nicotinic acetylcholine, GABA_A, and glycine receptors. While antibodies specific for the 5-HT_3A receptor subunit are plentiful, and have revealed a wealth of structural and functional information, few antisera exist for the detection of 5-HT_3B receptor subunits. Here we describe the generation and characterisation of a rabbit polyclonal antiserum that specifically recognises 5-HT_3B receptor subunits     

Dibenzyl Structuresin a Macromolecular Chain. III. Dibenzyldiisocyanates Reactivity

The reactivity of the 2,2′-, 2,4′-, 4,4′-dibenzyldiisocyanate (2,2′-, 2,4′-, 4,4′-DBDI) with n-butanol in benzene has been studied. The concentrations of all species were monitored by using high performance liquid chromatography (HPLC). The reactivity of 4,4′-DBDI is similar to that of 4,4′-diphenylmethanediisocyanate (4,4′-MDI). Very strong intramolecular catalytic effects were noticed in the case of 2,2′-DBDI, probably due to the variable molecular geometry. These effects are responsible for the whole reaction pattern. The 2,4′-DBDI NCO ortho and para groups reactivities are different and comparable to that of 2,4-toluylenediisocyanate (2,4-TDI).     

Long-range quantum gates using dipolar crystals

We propose the use of dipolar spin chains to enable long-range quantum logic between distant qubits. In our approach, an effective interaction between remote qubits is achieved by adiabatically following the ground state of the dipolar chain across the paramagnet to crystal phase transition. We demonstrate that the proposed quantum gate is particularly robust against disorder and derive scaling relations, showing that high-fidelity qubit coupling is possible in the presence of realistic imperfections. Possible experimental implementations in systems ranging from ultracold Rydberg atoms to arrays of nitrogen vacancy defect centers in diamond are discussed.