4-arylamino-2-(2-acetoxyethyl)amino-6-methylpyrimidines: Synthesis,deacetylation, and biological activity

The reaction of 2-(2-acetoxyethyl)amino-4-chloro-6-methylpyrimidine with aromatic amines leads to a series of 4-arylamino-2-(2-acetoxyethyl)amino-6-methylpyrimidines. Deacetylation of these compounds proceeds in both acidic and basic media. Most of the arylaminopyrimides obtained exhibit a pronounced antituberculous effect.     

Schrödinger Operators with Random Sparse Potentials. Existence of Wave Operators

We consider the connection problem for the Heun differential equation, which is a Fuchsian differential equation that has four regular singular points. We consider the case in which the parameters in this equation satisfy a certain set of conditions coming from the eigenvalue problem of the non-commutative harmonic oscillators. As an application, we describe eigenvalues with multiplicities greater than 1 and the corresponding odd eigenfunctions of the non-commutative harmonic oscillators. The existence of a rational or a certain algebraic solution of the Heun equation implies that the corresponding eigenvalues has multiplicities greater than 1.The research of the author is supported in part by a Grant-in-Aid for Scientific Research (B) (No. 15340005) from the Ministry of Education, Culture, Sports, Science and Technology.Mathematics Subject classifications (2000). primary, 34M35, secondary, 33E20.This revised version was published online in March 2005 with corrections to the cover date.     

Synthesis and antimicobacterial activity of 2-substituted 4-arylamino-6-methylpyrimidines

2-Substituted 4-arylamino-6-methylpyrimidines were synthesized by stepwise modification of the structure of 6-methyl-2-thiouracyl through the intermediate 2-(ar)alkylthio-6-methyl-4-chloropyrimidines. Some of the compounds synthesized exhibit expressed antimycobacterial activity.     

Study of Properties of Structural Materials of Powerful Pulsed Plasma Facilities under Extreme Loads

Physics of Atomic Nuclei - The effect of high-current relativistic electron beams on samples made of polycrystalline tungsten (Goodfellow) and corrosion-resistant ferrite-martensitic steel EK-181...     

1-(Pyrimidin-4-yl)pyrazol-5(4<Emphasis Type="Italic">H</Emphasis>)-one derivatives: II. Electrophilic substitution in 5-hydroxy-3-methyl-1-(6-methyl-2-methylsulfanylpyrimidin-4-yl)-1<Emphasis Type="Italic">H</Emphasis>-pyrazole

Electrophilic substitution of hydrogen in bicyclic 5-hydroxy-3-methyl-1-(6-methyl-2-methylsulfanylpyrimidin-4-yl)-1H-pyrazole occurs exclusively at the C⁴ atom of the five-membered heteroring. Unstable electrophilic substitution products are stabilized via addition of the second substrate molecule with formation of bridged adducts.     

Polyfluoroalloxy phosphonic and phosphinic acid derivatives: I. 1-Hydroxy-2,2,2-trichloroethylphosphinates

Polyfluoroalkyl esters of phosphoric, alkylphosphonic and 1-hydroxypolyfluoroalkylphosphonic acids exhibited significant antiesterase activity against various esterases of animal and microbial origin. Moreover, with some compounds reversible inhibition of enzymes was observed due to the specific influence of hydrophobic fragments of the target products.     

Complexes of 2-(4,6-dimethylpyrimidin-2-yl)-5-methyl-2<Emphasis Type="Italic">н</Emphasis>-pyrazol-3-ol with phenols: Formation,structure, stability

Fusion 2-(4,6-dimethylpyrimidin-2-yl)-5-methyl-2Н-pyrazol-3-ol with phenols leads to the formation of complexes which exist due to a system of intermolecular N···H–O hydrogen bonds. The complexes are stable at high temperatures: their melting and subsequent thermolysis are accompanied by endothermic effects.     

Statistical characteristics of the spatial structure of scattered radiation

Experimental results are given on the statistical characteristics of the spatial structure of scattered radiation as a function of the optical thickness and the number of scatterers. It is shown that the dispersion of the intensity fluctuations decreases with increase in the particle concentration in the scattering volume, and the correlation radius increases with increase in optical thickness. The dependence of the intensity-fluctuation dispersion on the scattering angle is obtained.Translated from Izvestiya Vysshikh Uchebnykh Zavedenii, Fizika, No. 12, pp. 44–47, December, 1978.Finally, it remains to thank Yu. A. Larionov, the head engineer of the Siberian Physicotechnical Institute, for assistance in the analysis of the experimental data.     

N-(3-Sulfanylmethyl-4H-1,2,4-triazol-4-yl)-2-sulfanylacetamide Containing Terminal 2-Amino-6-methylpyrimidin-4-yl Fragments. Synthesis from 2-[(2-Amino-6-methylpyrimidin-4-yl)sulfanyl]acetohydrazide and Triethyl Orthoformate

Russian Journal of Organic Chemistry - 2-[(2-Amino-6-methylpyrimidin-4-yl)sulfanyl]acetohydrazide reacted with triethyl orthoformate at a molar ratio of 1:1 to give...