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1.
Attempted reaction of indolenines (which represent rather sterically hindered cyclic imines) with a series of dicarboxylic acid anhydrides yielded no expected product, the Castagnoli-Cushman lactam. Instead, products presumably formed via N-acyliminium species trapping by a carboxylate anion. Among them, hydrolytically labile 2:2 adducts of an indolenine and a cyclic anhydride, containing a 16-membered cyclic core, are particularly intriguing. This result contradicts the recently reported successful Castagnoli-Cushman reaction of indolenines with homophthalic anhydride suggesting a mechanistic switch in the course of the reaction. 相似文献
2.
The one-pot, three-step, four-component Ugi-IMDAF reaction with 5-hydroxymethylfurfural provides simple access to hydroxymethyl-substituted epoxyisoindolones in a diastereoselective and stereospecific manner. The protocol avoids the transfer or isolation of isocyanides, and the broad scope was illustrated by the synthesis of 22 different compounds bearing various substituents on the heterocyclic core. 相似文献
3.
Novel types of hydrazinopeptide-like units containing five elements of diversity have been prepared in two steps using sequential
Ugi reactions. 相似文献
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5.
Mikhail A. Kuznetsov Aleksandr N. Shestakov Mikhail Zibinsky Mikhail Krasavin Claudiu T. Supuran Stanislav Kalinin Muhammet Tanç 《Tetrahedron letters》2017,58(2):172-174
Previously unknown N-aminosaccharin was prepared in good yield via the one-step direct amination of saccharin sodium salt with hydroxylamine-O-mesitylenesulfonic acid (MSH) and its reactivity investigated. N-aminosaccharin and its derivatives were tested against hCA isoforms and the parent compound was identified to be a selective, low micromolar inhibitor (Ki = 8.8 μM) of hCA I. These findings provide a ligand-efficient starting point for the design of potent hCA I inhibitors – a promising drug target for retinal/cerebral edema treatment. 相似文献
6.
M. Dubničková E. A. Kuzmina V. N. Chausov I. Ravnachka A. V. Boreyko E. A. Krasavin 《Physics of Particles and Nuclei Letters》2016,13(2):274-278
The modulatory effects of lipid A (diphosphoryl lipid A (DLA) and monophosphoryl lipid A (MLA)) on apoptosis induction and DNA structure damage (single and double-strand breaks (SSBs and DSBs, respectively)) in peripheral human blood lymphocytes are studied for 60Co gamma-irradiation. It is shown that in the presence of these agents the amount of apoptotic cells increases compared with the irradiated control samples. The effect is most strongly pronounced for DLA. In its presence, a significant increase is observed in the number of radiation-induced DNA SSBs and DSBs. Possible mechanisms are discussed of the modifying influence of the used agents on radiation-induced cell reactions 相似文献
7.
Crystallography Reports - A method based on a combination of Monte Carlo and gradient descent algorithms is presented for calculating the spectral density from the Green’s function. The... 相似文献
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9.
Schwanecke AS Krasavin A Bagnall DM Potts A Zayats AV Zheludev NI 《Physical review letters》2003,91(24):247404
We report unambiguous experimental evidence of broken time-reversal symmetry for the interaction of light with an artificial nonmagnetic material. Polarized color images of planar chiral gold-on-silicon nanostructures consisting of arrays of gammadions show intriguing and unusual symmetry: structures, which are geometrically mirror images, lose their mirror symmetry in polarized light. The symmetry of images can be described only in terms of antisymmetry (black-and-white symmetry) appropriate to a time-odd process. The effect results from a transverse chiral nonlocal electromagnetic response of the structure and has some striking resemblance with the expected features of light scattering on anyon matter. 相似文献
10.
A novel approach to skeletally diverse 3-oxoisoindolines has been developed which includes preparation of Ugi adducts containing thiophene and fumaric acid residues. When treated with excess m-CPBA at room temperature, these precursors undergo a simple oxidative cycloaddition/aromatization transformation and the corresponding 3-oxoisoindoline products are isolated in fair chemical yield over two steps. The second step is thought to include S-oxidation/IMDA/S-oxidation/SO2 extrusion/aromatization events. 相似文献