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Mahdieh Darroudi Sara Ranjbar Mohammad Esfandiar Mahsima Khoshneviszadeh Mahshid Hamzehloueian Mehdi Khoshneviszadeh Yaghoub Sarrafi 《应用有机金属化学》2020,34(12):e5962
In the present work, novel 5-((1-benzyl-1,2,3-triazol-4-yl)methoxybenzylidene)-2-(arylamino)thiazol-4-one thiazolone incorporated triazole derivatives have been designed as tyrosinase inhibitors. The compounds were synthesized through click reaction in good yield. Moreover, the antityrosinas activity of the synthesized derivatives was evaluated. In the search for establishing a click copper-catalyzed azide/alkyne cycloaddition (CuAAC) reaction under strict conditions, in terms of a novel air-stable, a recyclable and efficient magnetic catalyst was planned for new triazole derivatives as a well-organized copper iodide supported on the functionalized Fe3O4@SiO2 core-shell (CuI/Fe3O4@SiO2(TMS-EDTA) nanoparticles). The engineered nanocatalyst synthesized for the first time and characterized by different methods, including FT-IR spectroscopy, XRD, FESEM, EDX, TEM, TGA, and BET analysis. The excellent catalytic performance in ethanol with high surface area (351.7 m2g−1) and short reaction time for diverse functional groups (120–200 min), no use of toxic solvents, reusability of the catalyst, and using eco-friendly conditions are the advantageous of this work. Moreover,the nanocatalyst can be used at least five times without any significant decrease in the yield of the reaction. The thiazolidine-triazole derivatives 9a , 9c , 9e , and 9 g showed promising tyrosinase inhibitory activity with IC50 values in the range of 5.90–9.81 μM. The compounds were found to be considerably more potent tyrosinase inhibitors than the reference inhibitor kojic acid (IC50 = 18.36 μM). 相似文献
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Najmeh Edraki Aida Iraji Omidreza Firuzi Yousef Fattahi Mohammad Mahdavi Alireza Foroumadi Mehdi Khoshneviszadeh Abbas Shafiee Ramin Miri 《Journal of the Iranian Chemical Society》2016,13(12):2163-2171
The inhibition of AKR1B10 has been recognized as a potential therapeutic approach to the treatment of various types of cancers. A novel series of compounds with imino-2H-chromen and phenylimino-2H-chromen scaffolds were synthesized by Knoevenagel condensation reaction. The in vitro cytotoxic activity of synthesized compounds was evaluated against MOLT-4 and SK-OV-3 cells. Among the tested compounds, N-(3,4-dimethoxyphenyl)-2-(phenylimino)-2H-chromene-3-carboxamide (8g) demonstrated potent inhibitory activity against both examined cell lines. The results of the molecular docking study suggested that this compound is involved in critical hydrogen-bonding interactions with the Val301 and Lue302 of AKR1B10 catalytic site. 相似文献
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Ranjbar Sara Edraki Najmeh Firuzi Omidreza Khoshneviszadeh Mehdi Miri Ramin 《Molecular diversity》2019,23(2):471-508
Molecular Diversity - 5-Oxo-hexahydroquinoline (5-oxo-HHQ) represents a biologically attractive fused heterocyclic core. Various synthetic analogs of 5-oxo-HHQ have been synthesized and assessed... 相似文献
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Synthesis and Cytotoxic Activity of Some Novel Dihyrobenzo[h]pyrano[3,2‐c]chromene Derivatives 下载免费PDF全文
Nasim Esmati Mahsa Foroughian Mina Saeedi Mohammad Mahdavi Mehdi Khoshneviszadeh Omidreza Firuzi Nader Tanideh Ramin Miri Najmeh Edraki Abbas Shafiee Alireza Foroumadi 《Journal of heterocyclic chemistry》2015,52(1):97-104
Three‐component reaction of 4‐hydroxy‐2H‐benzo[h]chromen‐2‐one, aromatic aldehydes, and malononitrile in the presence of 1,4‐diazabicyclo[2.2.2]octane (DABCO) in ethanol at room temperature affords good yields of novel dihyrobenzo[h]pyrano[3,2‐c]chromene derivatives. The synthesized compounds examined by MTT assays for cytotoxic activity in two human cancer cell lines (MOLT‐4, HL‐60). Most of the evaluated compounds showed low inhibitory activity against tumor cell line at micromolar concentrations. 相似文献
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Ranjbar Sara Khoshneviszadeh Mehdi Tavakkoli Marjan Miri Ramin Edraki Najmeh Firuzi Omidreza 《Molecular diversity》2022,26(3):1481-1500
Molecular Diversity - Discovery of novel anticancer agents is of crucial importance to expand the therapeutic options for cancer patients. In this study, a series of 49 5-oxo-hexahydroquinoline and... 相似文献
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Tahmineh Akbarzadeh Saeedeh Noushini Somayeh Taban Mohammad Mahdavi Mahsima Khoshneviszadeh Mina Saeedi Saeed Emami Mohammad Eghtedari Yaghoub Sarrafi Mehdi Khoshneviszadeh Maliheh Safavi Kouros Divsalar Mohammad Hassan Moshafi Ali Asadipour Reyhaneh Sabourian Najmeh Edraki Omidreza Firouzi Ramin Miri Abbas Shafiee Alireza Foroumadi 《Molecular diversity》2015,19(2):273-281
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Emad Allahabadi Sina Ebrahimi Mehdi Soheilizad Mehdi Khoshneviszadeh Mohammad Mahdavi 《Tetrahedron letters》2017,58(2):121-124
A novel and efficient four-component approach for the synthesis of 2,3-disubstituted imidazo[1,2-a]pyridines is described. The copper-catalyzed reductive amination of 2-bromopyridine by sodium azide followed by sequential condensation and cyclization with aldehydes and isocyanides afforded the corresponding imidazo[1,2-a]pyridines in good yields. 相似文献
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Karimian Somaye Ranjbar Sara Dadfar Mahsa Khoshneviszadeh Mahsima Gholampour Maryam Sakhteman Amirhossein Khoshneviszadeh Mehdi 《Molecular diversity》2021,25(4):2339-2349
Molecular Diversity - A series of ethyl 2-amino-4H-benzo[h]chromene-3-carboxylate derivatives, having phenyl ring with diverse substituents at C4 position of 4H-benzochromene nucleus, were... 相似文献
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