Utilization of charge-transfer complexation in the spectrophotometric determination of some monosaccharides through their osazone intermediates

Monosaccharide osazones are utilized in the spectrophotometric determination of their parent compounds though charge-transfer complexation with two-electron acceptor reagents. The molar combining ratio and the optimum complexation conditions have been studied. The method has been used to analyse for glucose and fructose and in determining blood glucose.     

Interfacial Nanoprecipitation toward Stable and Responsive Microbubbles and Their Use as a Resuscitative Fluid

A new approach has been developed to prepare stable microbubbles (MBs) by interfacial nanoprecipitation of bioabsorbable polymers at air/liquid interfaces. This facile method offers robust control over the morphology and chemophysical properties of MBs by simple chemical modifications. This approach is amenable to large‐scale manufacturing, and is useful to develop functional MBs for advanced biomedical applications. To demonstrate this, a MB‐based intravenous oxygen carrier was created that undergoes pH‐triggered self‐elimination. Intravenous injection of previous MBs increased the risk of pulmonary vascular obstruction. However, we show, for the first time, that our current design is superior, as they 1) yielded no evidence of acute risks in rodents, and 2) improved the survival in a disease model of asphyxial cardiac arrest (from 0 to 100 %), a condition that affects more than 100 000 in‐hospital patients, and carries a mortality of about 90 %.     

Quantitative determination of mebeverine HCl by NMR chemical shift migration

Quantitative ¹H NMR spectroscopic methods are not frequently reported, but current NMR instrumentation allows ready access to such data. Mebeverine HCl is an attractive molecule for NMR spectroscopy teaching purposes as it possesses a variety of simple but significant functional groups; we fully assign its ¹H and ¹³C NMR spectra. Using mebeverine HCl, we show that concentration changes, in water as a solvent, can lead to significant changes in the ¹H chemical shifts of non-exchangeable aromatic protons and to a lesser extent to aromatic methoxy protons. An important observation is that different protons migrate to different extents as the concentration of the solute is varied, and thus the ¹H NMR spectra are concentration-dependent across a useful range. This chemical shift variation of selected protons was therefore analyzed and applied in the quantitative determination of mebeverine HCl in a medicine (Colofac IBS) formulated as a tablet. Self-association phenomena in water could account for these observed chemical shift migration effects as shown by determining the hydrodynamic radius from the modified form of the Stokes-Einstein equation, and thence the apparent hydrodynamic volume, V_H, for mebeverine HCl in D₂O solution which is 10-fold greater than that seen in either CDCl₃ or CD₃OD.     

Numerical modeling of a fast-axial-flow CW–CO2 laser

A four-temperature model has been applied on a fast axial flow, longitudinal discharge CO₂ laser. Using Runge–Kutta method, a set of differential equations of the model is numericaly solved. These equations describe the operation of the laser with certain ratio 1:3:6 of the mixture CO₂:N₂: He and average output power of 550 W.The temporal behaviour of the output power and photon density was obtained. The effects of kinetic temperature, coupled mirror reflectivity, gas flow speed, and cavity loss on the output power were studied.Calculated output power was compared with its measured value taken from experiment and a good agreement was observed.