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Chen Daquan Sun Jingfang Lian Shengnan Liu Zongliang Sun Kaoxiang Liu Wanhui Wu Zimei Zhang Qiang 《Journal of nanoparticle research》2014,16(11):1-7
Journal of Nanoparticle Research - Photochemical synthesis of selected multicomponent compounds, namely cadmium or magnesium zinc oxides doped with Ga3+ ions—Zn1?x Cd x (Mg x... 相似文献
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Jiangbin Han Shu Zhang Wanhui Liu Guangyi Leng Kaoxiang Sun Youxin Li Xin Di 《Analytical and bioanalytical chemistry》2014,406(9-10):2457-2465
Triptorelin, a gonadotropin-releasing hormone agonist, has been used in the treatment of hormone-responsive prostate cancer by inducing testosterone suppression. Research on the relationship between the time courses of triptorelin and testosterone is very important, but accurate quantification of triptorelin and testosterone simultaneously in biological specimens is a challenging analytical problem. In the present study, a rapid, sensitive, and selective method for simultaneous determination of triptorelin and testosterone in rat plasma by solid-phase extraction and liquid chromatography–tandem mass spectrometry was developed using a ZORBAX RRHD Eclipse Plus C8 column (2.1?×?50 mm, 1.8 μm) with a 0.05 % propionic acid/methanol gradient. In view of the polarity difference between the two analytes, two internal standards, i.e., leuprolide and testosterone-13C3, were used for individual quantitation of triptorelin and testosterone. Endogenous testosterone was determined by reference to a calibration curve prepared using testosterone-D3 as a surrogate analyte. The method exhibits excellent linearity over three orders of magnitude for each analyte. The lower limit of quantification was 0.01 ng/mL for triptorelin and 0.05 ng/mL for testosterone, with consumption of 100 μL of plasma. The method was successfully applied to characterize the pharmacokinetics and pharmacodynamics of slow-release 28-day form triptorelin acetate biodegradable microspheres in rats after intramuscular injections of three consecutive doses of 0.6 mg/kg per 28 days. The results revealed that the pharmacokinetic profile of triptorelin produced an initial flare-up in testosterone levels, rapid castration within 5 days after injection, and long-term castration until the next dose. Figure
Analytical strategy to characterize the PK/PD properties of triptorelin 相似文献
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Shi Yanan Sun Fengying Wang Dan Zhang Renyu Dou Changlin Liu Wanhui Sun Kaoxiang Li Youxin 《Journal of nanoparticle research》2013,15(10):1-10
The electron transport properties of CO adsorbed SiC nanotubes as a function of concentration density and structural deformation have been characterized for the single-walled (7,0) zigzag model using a combined formalism of density-functional theory and nonequilibrium Green’s function. It is found that CO adsorption can significantly suppress the transmission spectrum of SiC nanotube for a wide range of energies. As the concentration increases, a density-dependent superimposed transport gap exists and widens the initial electronic band gap of SiC nanotube. Under the same applied bias voltage, the current through SiC nanotube decreases with the increasing CO concentrations. The local torsional deformation has no effect on this essential motif. However, the current in the locally twisted system is larger than that of the undeformed one. The transmission suppression and the current differences can be attributed to the response of the localized impurity state induced by CO adsorption to density and deformation. Our results show that SiC nanotube can be a promising gas sensor for CO detection. 相似文献
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