High repetition rate, tunable, Q-switched diode pumped Tm:YLF laser

The aim of work was to characterize a simple oscillator consisted of Tm:YLF crystal end-pumped by a fiber coupled diode laser and active Q-switch with tunability option. About 7 W with near 35% slope efficiency was demonstrated in a free-running mode. The divergence angle was about 4.3 mrad and estimated parameter M² < 1.3. Continuous tuning by means of Lyot’s filter, consisted of 2 quartz plates in the range of 1879.0–1939.4 nm with less than 1-nm linewidth, was achieved. For the best case (10-ms pump pulse duration, 42-A pump current corresponding to 266 mJ of pump energy), the Q-switched energy was 10.5 mJ with pulse duration of 22 ns corresponding to near 0.5 MW peak power. The 2.5 W of average power with 12.6-kW peak power and 2000-Hz repetition rate was demonstrated for cw pumping regime.     

Self-cleaning effect of sealing caps for infrared hollow fiber delivering pulsed Er:YAG laser light

A sealing cap had been proposed as an output device for hollow optical fibers in delivering laser light underwater. Properties of sealing cap were experimentally discussed when used in ablation on soft tissue for Er:YAG laser. A self-cleaning effect of the sealing cap was observed when various targets were used for different laser light power. Debris from pork fat formed a uniform oil layer on the output surface of the cap, and the oil layer is relatively transparent in Er:YAG laser light wavelength band. When the target was pork muscle, almost no debris could attach on the surface of the cap. The self-cleaning effect was more obvious when ablation was conducted underwater because of the protection of the water film between the target and the cap's surface.     

Europium and terbium Schiff base peptide complexes as potential antimicrobial agents against <Emphasis Type="Italic">Salmonella typhimurium</Emphasis> and <Emphasis Type="Italic">Pseudomonas aeruginosa</Emphasis>

Eu(III) and Tb(III) Schiff base complexes are applicable in various fields such as sensing, assays, screening protocols in vitro, and imaging studies in vitro or in vivo. Fluorescent europium and terbium complexes and their interaction with cell penetrating peptide (KKKRKC) can represent an excellent key for understanding pathway of peptide transportation though cell membrane and the application of Schiff base complexes as potential antibacterial drugs. The Schiff base–metal complexes and its conjugates with peptide were tested for their antibacterial activity against Pseudomonas aeruginosa and Salmonella typhimurium. Schiff base–metal complexes conjugated with peptide show minor toxicity in normal human PNT1A cells and high antibacterial activity against P. aeruginosa and S. typhimurium, where IC50 down to 125.9 and/or 36.1 µM were found for P. aeruginosa and S. typhimurium, respectively. Our results strongly suggest that Schiff base–metal complexes conjugated with peptide have great potential to be developed into highly effective antibacterial drug.     

Resonantly pumped,high peak power Er:YAG laser

The high peak power hybrid Er:YAG laser, resonantly pumped at the wavelength of 1532 nm was developed. The fused silica acousto-optic modulator driven by 10 W of RF power was deployed as the Q-switch for such a laser. For the best case of Q-switching regime the pulses of 110 kW peak power (4 mJ, 37 ns) were reached at the pump power of 7.8 W and the repetition rate of 500 Hz.