Subchronic oral toxicity (six months) of carboxyethylgermanium sesquioxide [(HOOCCH2CH2Ge)2O3]n in rats

After briefly renewing toxicological data on germanium compounds, the authors report on the subchronic oral toxicity of carboxyethylgermanium sesquioxide in rats. During six months, male and female animals received 1 g kg^?1. day^?1. No particular toxic symptoms, and no behaviour problems except a small decrease of body weight in male rats, at the end of the six-month experimentation period, were observed. A significant decrease of erythropoiesis and some significant changes in leucocyte ratios were demonstrated. The main marked effect was a moderate renal dysfunction characterized by a tubular disease with the presence of cylinders, swelling of tubulus cells and flocculus deposits. Germanium urinary excretion was constant and linked to the received dose. Six months later, no preferential accumulation in organs was evident.     

Limit theorems for triangular urn schemes

We study a generalized Pólya urn with balls of two colours and a triangular replacement matrix; the urn is not required to be balanced. We prove limit theorems describing the asymptotic distribution of the composition of the urn after a long time. Several different types of asymptotics appear, depending on the ratio of the diagonal elements in the replacement matrix; the limit laws include normal, stable and Mittag-Leffler distributions as well as some less familiar ones. The results are in some cases similar to, but in other cases strikingly different from, the results for irreducible replacement matrices.     

Coupling and Poisson approximation

We give an overview of the Stein-Chen method for establishing Poisson approximations of various random variables. Couplings of certain variables are used to gives explicit bounds for the total variation distance between the distribution of a random variable and a Poisson variable. Some applications are given. In some cases, explicit couplings may be used to obtain good estimates; in other applications it suffices to show the existence of couplings with certain monotonicity properties.Supported by the Göran Gustafsson Foundation for Research in Natural Sciences and Medicine.     

Scaling of microtubule force-velocity curves obtained at different tubulin concentrations

We present a single curve that describes the decay in average growth velocity for microtubules in response to a mechanical force. Curves obtained at two new and one previously studied tubulin concentrations coalesce when normalized with the growth velocity at zero load. This scaling provides direct evidence for a force-independent molecular off rate, in agreement with Brownian ratchet models. In addition, microtubule length changes were measured with a precision up to 10 nm, revealing that microtubules under load abruptly switch between different growth velocities.     

The size of random fragmentation trees

We consider the random fragmentation process introduced by Kolmogorov, where a particle having some mass is broken into pieces and the mass is distributed among the pieces at random in such a way that the proportions of the mass shared among different daughters are specified by some given probability distribution (the dislocation law); this is repeated recursively for all pieces. More precisely, we consider a version where the fragmentation stops when the mass of a fragment is below some given threshold, and we study the associated random tree. Dean and Majumdar found a phase transition for this process: the number of fragmentations is asymptotically normal for some dislocation laws but not for others, depending on the position of roots of a certain characteristic equation. This parallels the behavior of discrete analogues with various random trees that have been studied in computer science. We give rigorous proofs of this phase transition, and add further details. The proof uses the contraction method. We extend some previous results for recursive sequences of random variables to families of random variables with a continuous parameter; we believe that this extension has independent interest.     

Small cliques in random graphs

For d ≥ 1, a d-clique in a graph G is a complete d-vertex subgraph not contained in any larger complete subgraph of G. We investigate the limit distribution of the number of d-cliques in the binomial random graph G(n, p), p = p(n), n→∞.     

Acoustic detection and classification of river boats

We present a robust algorithm to detect the arrival of a boat of a certain type when other background noises are present. It is done via the analysis of its acoustic signature against an existing database of recorded and processed acoustic signals. We characterize the signals by the distribution of their energies among blocks of wavelet packet coefficients. To derive the acoustic signature of the boat of interest, we use the Best Discriminant Basis method. The decision is made by combining the answers from the Linear Discriminant Analysis (LDA) classifier and from the Classification and Regression Trees (CART) that is also accompanied with an additional unit, called Aisles, that reduces false alarms rate. The proposed algorithm is a generic solution for process control that is based on a learning phase (training) followed by an automatic real time detection while minimizing the false alarms rate.     

EPR Studies of Tl0.5Pb0.5Sr1.6Ba0.4CaCu2?xRuxO7?δ Superconductor

Bulk superconducting samples of type Tl_0.5Pb_0.5Sr_1.6Ba_0.4CaCu_2−x Ru _x O_7−δ, (Tl, Pb)/Sr-1212, with 0.0 ≤ x ≤ 0.525 were prepared by the conventional one-step solid-state reaction technique. The prepared samples were investigated using X-ray powder diffraction, electrical resistivity and electron paramagnetic resonance (EPR) measurements. Enhancement of the phase formation, superconducting transition temperature T _c and hole carriers concentration P was observed up to x = 0.075. For x > 0.075, a reverse trend was observed. EPR spectra were measured at different temperatures (120–290 K) for all prepared samples. The number of spins N participating in the resonance and the paramagnetic susceptibility χ were calculated as a function of both Ru-content and temperature. N and χ increased as the Ru-content increased. A linear relationship between logN and 1/T was established, from which the activation energy E _a was calculated as a function of the Ru-content. The temperature dependence of χ was fitted according to Curie–Weiss type of magnetic behavior. Curie constant C, Curie temperature θ, the effective magnetic moment μ and the electronic specific heat γ were estimated as a function of the Ru-content.     

Asymptotic bias of some election methods

Consider an election where N seats are distributed among parties with proportions p ₁,…,p _m of the votes. We study, for the common divisor and quota methods, the asymptotic distribution, and in particular the mean, of the seat excess of a party, i.e. the difference between the number of seats given to the party and the (real) number Np _i that yields exact proportionality. Our approach is to keep p ₁,…,p _m fixed and let N→∞, with N random in a suitable way. In particular, we give formulas showing the bias favouring large or small parties for the different election methods.     

Spread‐out percolation in ℝd

Fix d ≥ 2, and let X be either ℤ^d or the points of a Poisson process in ℝ^d of intensity 1. Given parameters r and p, join each pair of points of X within distance r independently with probability p. This is the simplest case of a “spread‐out” percolation model studied by Penrose [Ann Appl Probab 3 (1993) 253–276], who showed that, as r → ∞, the average degree of the corresponding random graph at the percolation threshold tends to 1, i.e., the percolation threshold and the threshold for criticality of the naturally associated branching process approach one another. Here we show that this result follows immediately from of a general result of [3] on inhomogeneous random graphs. © 2007 Wiley Periodicals, Inc. Random Struct. Alg., 2007