排序方式: 共有47条查询结果,搜索用时 78 毫秒
1.
2.
3.
Background
Parkinson's disease, a prevalent neurodegenerative disease, is characterized by the reduction of dopaminergic neurons resulting in the loss of motor control, resting tremor, the formation of neuronal inclusions and ultimately premature death. Two inherited forms of PD have been linked to mutations in the α-synuclein and parkin genes. The parkin protein functions as an ubiquitin ligase targeting specific proteins for degradation. Expression of human α-synuclein in Drosophila neurons recapitulates the loss of motor control, the development of neuronal inclusions, degeneration of dopaminergic neurons and the ommatidial array to provide an excellent genetic model of PD.Results
To investigate the role of parkin, we have generated transgenic Drosophila that conditionally express parkin under the control of the yeast UAS enhancer. While expression of parkin has little consequence, co-expression of parkin with α-synuclein in the dopaminergic neurons suppresses the α-synuclein-induced premature loss of climbing ability. In addition directed expression of parkin in the eye counteracts the α-synuclein-induced degeneration of the ommatidial array. These results show that parkin suppresses the PD-like symptoms observed in the α-synuclein-dependent Drosophila model of PD.Conclusion
The highly conserved parkin E3 ubiquitin ligase can suppress the damaging effects of human α-synuclein. These results are consistent with a role for parkin in targeting α-synuclein to the proteasome. If this relationship is conserved in humans, this suggests that up-regulation of parkin should suppress α-synucleinopathic PD. The development of therapies that regulate parkin activity may be crucial in the treatment of PD.4.
We study many-body quantum dynamics of delta-interacting bosons confined in a one-dimensional ring. Main attention is paid to the transition from the mean-field to the Tonks-Girardeau regime using an approach developed in the theory of interacting particles. We analyze, both analytically and numerically, how the Shannon entropy of the wave function and the momentum distribution depend on time for weak and strong interactions. We show that the transition from regular (quasiperiodic) to irregular ("chaotic") dynamics coincides with the onset of the Tonks-Girardeau regime. In the latter regime, the momentum distribution of the system reveals a statistical relaxation to a steady state distribution. The transition can be observed experimentally by studying the interference fringes obtained after releasing the trap and letting the boson system expand ballistically. 相似文献
5.
The phase behavior of rod-plate mixtures was investigated using model systems containing unambiguously rod- and plate-shaped colloids. We find that the theoretically disputed biaxial nematic phase is unstable with respect to demixing into an isotropic and two uniaxial nematic phases. The phase behavior at very high densities is exceptionally rich and includes the coexistence of up to four different liquid crystalline phases, which stem from the coupling between the employed particle shapes and polydispersity. 相似文献
6.
P. Dougan Dr. T. Kivikas FM K. Lugnér V. Ramsay W. Stiefler 《Zeitschrift für Physik A Hadrons and Nuclei》1976,276(1):55-64
The cross-sections for deuteron photo-disintegration have been measured at nine c.m. angles from 37 to 143 degrees. The minimum and maximum photon energies have been 139 and 832 MeV respectively. The results are in agreement with earlier data above 300 MeV, but are significantly larger below 200 MeV, the discrepancies being up to 50% at the lowest energies measured. 相似文献
7.
8.
Fritz Haake Felix Izrailev Nils Lehmann Dirk Saher Hans-Jürgen Sommers 《Zeitschrift für Physik B Condensed Matter》1992,88(3):359-370
We present analytical and numerical results for the level density of a certain class of random non-Hermitian matrices =H+i. The conservative partH belongs to the Gaussian orthogonal ensemble while the damping piece is quadratic in Gaussian random numbers and may describe the decay of resonances through various channels. In the limit of a large matrix dimension the level density assumes a surprisingly simple dependence on the relative strength of the damping and the number of channels. Moreover, we identify situations with cubic repulsion between the complex eigenvalues of , to within a logarithmic correction. 相似文献
9.
10.
Xu H Izrailev S Agrafiotis DK 《Journal of chemical information and computer sciences》2003,43(4):1186-1191
A new stochastic algorithm for conformational sampling is described. The algorithm generates molecular conformations that are consistent with a set of geometric constraints, which include interatomic distance bounds and chiral volumes derived from the molecular connectivity table. The algorithm repeatedly selects individual geometric constraints at random and updates the respective atomic coordinates toward satisfying the chosen constraint. When compared to a conventional distance geometry algorithm based on the same set of geometric constraints, our method is faster and generates conformations that are more diverse and more energetically favorable. 相似文献