排序方式: 共有42条查询结果,搜索用时 15 毫秒
1.
A series of molecules of therapeutic interest, possessing the new skeleton of 1H-benzo[c]pyrido[2,3,4-kl]acridine with acyl or aminoacyl and methoxy or aminoalkoxy substituents on the aromatic homocycles were synthesized by means of a Friedl?nder-type reaction. The requisite 5-aminodihydroquinoline-4-ones 1, whose preparation is described, were reacted with the appropriate alpha-tetralones 2 using an acidic catalyst (PPTS) under azeotropic conditions. Optimized reaction time and yield depend on temperature, which must not be below 90 degrees C. 相似文献
2.
射频囚禁离子被广泛应用于量子信息和冷分子制备. 对于从单个离子到10^6个离子不等的样品,这些原子的内能和外能可以被控制到非常高的精度. 重点讨论了利用射频囚禁的Ca+来作为频率计量的标准方法. 相似文献
3.
Klupsch F Houssin R Humbert L Imbenotte M Hénichart JP Lhermitte M 《Chemical & pharmaceutical bulletin》2006,54(9):1318-1321
An expeditious route to the two major metabolites of Zolpidem-and readily applicable to the synthesis of the drug-was established via a cyclization reaction between a 2-aminopyridine and a suitable alpha-bromoacetophenone. The structures of the target compounds were confirmed from a 2D (1)H-(15)N NMR correlation. Their mass spectra contribute to a reliable toxicological identification of the drug in the case of drug-facilitated crimes. 相似文献
4.
Bertrand Le Bourdonnec Emmanuelle Meulon Saïd Yous Raymond Houssin Jean‐Pierre Hnichart 《Journal of heterocyclic chemistry》2000,37(5):1209-1212
N‐alkyl pyrazolidine‐3,5‐diones and tetrahydropyridazine‐3,6‐diones have been synthesized by a new method in a three‐step sequence from dialkyl malonates or succinates respectively. 相似文献
5.
Rodolphe Alchaar Houssin Makhlouf Nadine Abboud Sophie Tingry Radhouane Chtourou Matthieu Weber Mikhael Bechelany 《Journal of Solid State Electrochemistry》2017,21(10):2877-2886
A new process enabling the synthesis of zinc oxide (ZnO) and Al-doped ZnO nanowires (NWs) for photosensing applications is reported. By combining atomic layer deposition (ALD) for the seed layer preparation and electrodeposition for the NW growth, high-quality ZnO nanomaterials were prepared and tested as ultraviolet (UV) sensors. The obtained NWs are grown as arrays perpendicular to the substrate surface and present diameters between 70 and 130 nm depending on the Al doping, as seen from scanning electron microscopy (SEM) studies. Their hexagonal microstructure has been determined using X-ray diffraction and Raman spectroscopy. An excellent performance in UV sensing has been observed for the ZnO NWs with low Al doping, and a maximal photoresponse current of 11.1 mA has been measured. In addition, initial studies on the stability have shown that the NW photoresponse currents are stable, even after ten UV on/off cycles. 相似文献
6.
7.
8.
Raymond Houssin Jean-Luc Bernier Jean-Pierre Hnichart 《Journal of heterocyclic chemistry》1985,22(5):1185-1187
An unequivocal synthesis of a new thiazolo[2,3-c]-s-triazole substituted at the C-5 position by a very useful methyl triphenylphosphonium salt has been achieved starting from the corresponding 2-isopropylidenehydrazinylthiazole and formic acid. Ring closure was found to be very easy without isolation of a formylhydrazino intermediate. The thiazole derivative was prepared from isopropylidenethiosemicarbazide and (3-chloro-2-oxo)propyltriphenylphosphonium chloride in a good yield. 相似文献
9.
Ryckebusch A Gilleron P Millet R Houssin R Lemoine A Pommery N Grellier P Sergheraert C Hénichart JP 《Chemical & pharmaceutical bulletin》2005,53(10):1324-1326
Protein farnesyltransferase of Plasmodium falciparum is a potential target in the treatment of malaria for which increased drug resistance is observed. The design, synthesis and evaluation of a series of N-(4-piperidinyl)benzamides is reported. The most potent compounds showed in vitro activity against the parasite at submicromolar concentrations. 相似文献
10.
Magusin PC Zorin VE Aerts A Houssin CJ Yakovlev AL Kirschhock CE Martens JA van Santen RA 《The journal of physical chemistry. B》2005,109(48):22767-22774
Species at three stages in the self-assembly of zeolite ZSM-5 have been studied with one- and two-dimensional magic-angle-spinning 13C, 27Al, 29Si, and 1H NMR spectroscopy and compared with the earlier proposed structures: (1) precursor species containing 33-36 T sites around a tetrapropylammonium (TPA) cation, (2) nanoslabs consisting of a flat 4 x 3 array of such precursors, and (3) the final TPA-ZSM-5 zeolite. Synthesis was carried out in D2O to suppress the water and silanol protons. Under such conditions, the effective Si-H and Al-H distances measured with 29Si-{1H} and 27Al-{1H} rotational echo double resonance (REDOR) reflect the interactions between TPA cations and the surrounding aluminosilica. The 29Si-{1H} REDOR curves for Q4-type silicon atoms at the three mentioned stages are closely similar, as well as the observed 27Al-1H REDOR curve for the precursor species compared to that for the TPA-ZSM-5. This indicates that in addition to externally attached TPA, there is also internal TPA already incorporated at an early stage into the aluminosilicate in a similar way as in the final zeolite, in accordance with the earlier proposed MFI self-assembly pathway (Kirschhock et al. Angew. Chem. Int. Ed. 2001, 40, 2637). However, the effective distances extracted from the initial REDOR curvatures are significantly (10-15%) larger than those computed for the model. Since there is no temperature effect, we tentatively assign this difference to a reduction of the 29Si-1H and 27Al-1H interactions by multispin decoherence effects or self-decoupling caused by proton spin diffusion. By assuming the computed model distances and fitting Anderson-Weiss curves to the observed REDOR data, we obtain similar "decoherence times" in the order of 0.1 ms. The observed 29Si-{1H} REDOR dephasing for the Q3 sites in the precursors is significantly faster than that for the Q4 sites. This is tentatively ascribed to a partial deuteron-proton back exchange at the silanol positions. 相似文献