The role of visual speech cues in reducing energetic and informational masking

Two experiments compared the effect of supplying visual speech information (e.g., lipreading cues) on the ability to hear one female talker's voice in the presence of steady-state noise or a masking complex consisting of two other female voices. In the first experiment intelligibility of sentences was measured in the presence of the two types of maskers with and without perceived spatial separation of target and masker. The second study tested detection of sentences in the same experimental conditions. Results showed that visual cues provided more benefit for both recognition and detection of speech when the masker consisted of other voices (versus steady-state noise). Moreover, visual cues provided greater benefit when the target speech and masker were spatially coincident versus when they appeared to arise from different spatial locations. The data obtained here are consistent with the hypothesis that lipreading cues help to segregate a target voice from competing voices, in addition to the established benefit of supplementing masked phonetic information.     

Buckling of actin-coated membranes under application of a local force

The mechanical properties of composite membranes obtained by self-assembly of actin filaments with giant fluid vesicles are studied by micromanipulation with optical tweezers. These complexes exhibit typical mechanical features of a solid shell, including a finite in-plane shear elastic modulus ( approximately 10(-6) N/m). A buckling instability is observed when a localized force of the order of 0.5 pN is applied perpendicular to the membrane plane. Although predicted for polymerized vesicles, this is the first evidence of such an instability.     

A phase I, randomized study of combined IL-2 and therapeutic immunisation with antiretroviral therapy

Background  

Fully functional HIV-1-specific CD8 and CD4 effector T-cell responses are vital to the containment of viral activity and disease progression. These responses are lacking in HIV-1-infected patients with progressive disease. We attempted to augment fully functional HIV-1-specific CD8 and CD4 effector T-cell responses in patients with advanced chronic HIV-1 infection.     

The general solution of the vacuum einstein equation in the limit of strong gravity

The general solution to the strong coupling limit of the vacuum Einstein field equations is obtained. This limit is related to the theory of symmetric spaces.On leave from the Department of Mathematics, Monash University, Clayton, Victoria, 3168, Australia.On leave from F.A.M.A.F., Laprida 854, University of Cordoba, 5000 Cordoba, Argentina.On leave from the Physics Department, Jamestown Community College, Jamestown, N.Y. 14701.     

Variability and uncertainty in masking by competing speech

This study investigated the role of uncertainty in masking of speech by interfering speech. Target stimuli were nonsense sentences recorded by a female talker. Masking sentences were recorded from ten female talkers and combined into pairs. Listeners' recognition performance was measured with both target and masker presented from a front loudspeaker (nonspatial condition) or with a masker presented from two loudspeakers, with the right leading the front by 4 ms (spatial condition). In Experiment 1, the sentences were presented in blocks in which the masking talkers, spatial configuration, and signal-to-noise (S-N) ratio were fixed. Listeners' recognition performance varied widely among the masking talkers in the nonspatial condition, much less so in the spatial condition. This result was attributed to variation in effectiveness of informational masking in the nonspatial condition. The second experiment increased uncertainty by randomizing masking talkers and S-N ratios across trials in some conditions, and reduced uncertainty by presenting the same token of masker across trials in other conditions. These variations in masker uncertainty had relatively small effects on speech recognition.