Most recent strategies targeting estrogen receptor alpha for the treatment of breast cancer

Molecular Diversity - Breast cancer is the most prominent, frequently diagnosed and leading cause of death among women. Estrogen is an agonist of estrogen receptor alpha (ER-α), expressed in...     

Therapeutic Potential of Targeting the HMGB1/RAGE Axis in Inflammatory Diseases

High mobility group box 1 (HMGB1) is a nuclear protein that can interact with a receptor for advanced glycation end-products (RAGE; a multi-ligand immunoglobulin receptor) and mediates the inflammatory pathways that lead to various pathological conditions, such as cancer, diabetes, neurodegenerative disorders, and cardiovascular diseases. Blocking the HMGB1/RAGE axis could be an effective therapeutic approach to treat these inflammatory conditions, which has been successfully employed by various research groups recently. In this article, we critically review the structural insights and functional mechanism of HMGB1 and RAGE to mediate inflammatory processes. More importantly, current perspectives of recent therapeutic approaches utilized to inhibit the communication between HMGB1 and RAGE using small molecules are also summarized along with their clinical progression to treat various inflammatory disorders. Encouraging results are reported by investigators focusing on HMGB1/RAGE signaling leading to the identification of compounds that could be useful in further clinical studies. We highlight the current gaps in our knowledge and future directions for the therapeutic potential of targeting key molecules in HMGB1/RAGE signaling in the pathophysiology of inflammatory diseases.     

Excess volumes of binary liquid mixtures of benzaldehyde and acetophenone with hydrocarbons,carbon tetrachloride,and chloroform

Molar excess volumes of benzaldehyde and acetophenone with cyclohexane, benzene, toluene, p-xylene, chloroform, and carbon tetrachloride were measured at 25 and 35°C as a function of composition.     

Rational approaches for the design of various GABA modulators and their clinical progression

Molecular Diversity - GABA (γ-amino butyric acid) is an important inhibitory neurotransmitter in the central nervous system. Attenuation of GABAergic neurotransmission plays an important role...