排序方式: 共有28条查询结果,搜索用时 15 毫秒
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Lynch CL Hale JJ Budhu RJ Gentry AL Finke PE Caldwell CG Mills SG MacCoss M Shen DM Chapman KT Malkowitz L Springer MS Gould SL DeMartino JA Siciliano SJ Cascieri MA Carella A Carver G Holmes K Schleif WA Danzeisen R Hazuda D Kessler J Lineberger J Miller M Emini E 《Organic letters》2003,5(14):2473-2475
[reaction: see text] A novel approach to alpha,alpha-disubstituted-beta-amino acids (beta(2,2)-amino acids) was employed in the synthesis of a series of 3-(pyrrolidin-1-yl)propionic acids possessing high affinity for the CCR5 receptor and potent anti-HIV activity. The rat pharmacokinetics for these new analogues featured higher bioavailabilities and lower rates of clearance as compared to cyclopentane 1. 相似文献
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Shaw SJ Schiffers WP Gentry TP Emmony DC 《The Journal of the Acoustical Society of America》2000,107(6):3065-3072
In this paper new observations of a laser-generated cavitation bubble interacting with an inertial boundary are presented. Employing schlieren photography techniques and a thin film transducer placed on the surface of the boundary, the pressure stresses induced in the solid boundary and the surrounding fluid by collapsing bubbles, created very close to the solid surface, are experimentally measured. Liquid jet development, shock wave emission, and "splash" phenomena are identified. For different creation sites close to the boundary, the relevance of each of these phenomena with respect to potentially damaging pressure stresses in the boundary is speculated on. 相似文献
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The energy-loss spectra for H+ scattered at small angles from CH4 and CD4 display an unusual bimodal character and extremely large average excitation energies. We propose a potential energy surface-hopping mechanism to account for the novel features of this system. 相似文献
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Regulacio MD Pablico MH Vasquez JA Myers PN Gentry S Prushan M Tam-Chang SW Stoll SL 《Inorganic chemistry》2008,47(5):1512-1523
We have discovered room temperature photoluminescence in Sm3+ and Pr3+ dithiocarbamate complexes. Surprisingly, these complexes exhibit more intense emission than those of the Eu3+, Tb3+, and Dy3+ analogues. The electronic absorption, excitation, and emission spectra are reported for the complexes [Ln(S2CNR2)3L] and NH2Et2[Ln(S2CNEt2)4], where Ln = Sm, Pr; R = ethyl, ibutyl, benzyl; and L = 1,10-phenanthroline, 2,2'-bipyridine, and 5-chloro-1,10-phenanthroline. The lowest ligand-localized triplet energy level (T1) of the complexes are determined from the phosphorescence spectra of analogous La3+ and Gd3+ chelates. The luminescence decay curves were measured to determine the excited-state lifetimes for the Pr3+ and Sm3+ complexes. X-ray crystal structures of Sm(S2CNiBu2)3phen, Pr(S2CNEt2)3phen, and Pr(S2CNiBu2)3phen are also reported. 相似文献
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Gentry EJ Telikepalli H Srinivas P Mitscher LA 《Combinatorial chemistry & high throughput screening》2003,6(2):139-145
Boron-based mixed anhydrides are rapidly reactive, easy to prepare, cheap, efficient, and general acylating reagents capable of selectivity when chelation is possible. High yields of various esters, amides and thioesters are quickly obtainable and the products are easy to isolate in high purity. The method is readily used under multiple parallel synthesis conditions and is readily scaleable. 相似文献
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Wind measurements with 355-nm molecular Doppler lidar 总被引:19,自引:0,他引:19
A Doppler lidar system based on the molecular double-edge technique is described. The system is mounted in a modified van to permit deployment in field operations. The lidar operates with a tripled Nd:YAG laser at 355 nm, a 45-cm-aperture telescope, and a matching azimuth-over-elevation scanner to permit full sky access. Validated atmospheric wind profiles were measured from 1.8 to 35 km with a 178-m vertical resolution. The range-dependent rms deviation of the horizontal wind speed is 0.4-6 m/s. The measured wind speed and direction are in good agreement with the rawinsonde wind measurements made simultaneously from the same location. 相似文献
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Roosevelt Gentry 《Journal of Mathematical Analysis and Applications》1980,76(2):369-377
In this paper, we use the author's diagram proof of Riesz's theorem together with special seminorms to show that two theorems proved by the author generalize a compact interpolation theorem of Krasnoselskii, and a compact interpolation theorem of Juberg. 相似文献
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