排序方式: 共有21条查询结果,搜索用时 31 毫秒
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Chernomordik V Hattery D Gandjbakhche AH Pifferi A Taroni P Torricelli A Valentini G Cubeddu R 《Optics letters》2000,25(13):951-953
We have extended a random-walk theory that uses time-dependent contrast functions to quantify the cross section and the corrected scattering and absorption coefficients of abnormal nonlocalized targets from time-of-flight (TOF) data obtained in time-resolved transillumination experiments. Experimental TOF's are used to show that this newly developed random-walk method is able to quantify the size and the optical properties of embedded nonlocalized targets in with an error rate of =25%. 相似文献
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Chernomordik V Gandjbakhche AH Hassan M Pajevic S Weiss GH 《Optics Communications》2010,283(23):4832-4839
We develop an analytic model of time-resolved fluorescent imaging of photons migrating through a semi-infinite turbid medium bounded by an infinite plane in the presence of a single stationary point fluorophore embedded in the medium. In contrast to earlier models of fluorescent imaging in which photon motion is assumed to be some form of continuous diffusion process, the present analysis is based on a continuous-time random walk (CTRW) on a simple cubic lattice, the objective being to estimate the position and lifetime of the fluorophore. This can provide information related to local variations in pH and temperature with potential medical significance. Aspects of the theory were tested using time-resolved measurements of the fluorescence from small inclusions inside tissue-like phantoms. The experimental results were found to be in good agreement with theoretical predictions provided that the fluorophore was not located too close to the planar boundary, a common problem in many diffusive systems. 相似文献
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In this article, we derive the intrinsic equations for a generalized relaxed elastic line on an oriented surface in the Galilean 3-dimensional space G3. These equations will give direct and more geometric approach to questions concerning about generalized relaxed elastic lines on an oriented surface in G3. 相似文献
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Lenneke WA van Hooijdonk Muhammad Ichwan Thomas F Dijkmans Theo G Schouten Marijke WA de Backer Roger AH Adan Fons J Verbeek Erno Vreugdenhil Carlos P Fitzsimons 《BMC neuroscience》2009,10(1):2-19
Background
In the adult hippocampus, the granule cell layer of the dentate gyrus is a heterogeneous structure formed by neurons of different ages, morphologies and electrophysiological properties. Retroviral vectors have been extensively used to transduce cells of the granule cell layer and study their inherent properties in an intact brain environment. In addition, lentivirus-based vectors have been used to deliver transgenes to replicative and non-replicative cells as well, such as post mitotic neurons of the CNS. However, only few studies have been dedicated to address the applicability of these widespread used vectors to hippocampal cells in vivo. Therefore, the aim of this study was to extensively characterize the cell types that are effectively transduced in vivo by VSVg-pseudotyped lentivirus-based vectors in the hippocampus dentate gyrus. 相似文献9.
Marijke WA de Backer Carlos P Fitzsimons Maike AD Brans Mieneke CM Luijendijk Keith M Garner Erno Vreugdenhil Roger AH Adan 《BMC neuroscience》2010,11(1):81
Background
This study compared the transduction efficiencies of an adeno-associated viral (AAV) vector, which was pseudotyped with an AAV1 capsid and encoded the green fluorescent protein (GFP), with a lentiviral (LV) vector, which was pseudotyped with a VSV-G envelop and encoded the discosoma red fluorescent protein (dsRed), to investigate which viral vector transduced the lateral hypothalamus or the amygdala more efficiently. The LV-dsRed and AAV1-GFP vector were mixed and injected into the lateral hypothalamus or into the amygdala of adult rats. The titers that were injected were 1 × 108 or 1 × 109 genomic copies of AAV1-GFP and 1 × 105 transducing units of LV-dsRed. 相似文献10.
The equations of magnetostatic equilibria for a plasma in agravitational field are investigated analytically. For equilibriawith an ignorable spatial coordinate, the equations reduce toa single nonlinear elliptic equation for the magnetic potentialu known as the Grad-Shafranov equation. By specifying the arbitraryfunctions in this equation, a Liouville equation is obtained.Bäcklund transformations are described and applied to obtainexact solutions for the Liouville equation modelling an isothermalmagnetostatic atmosphere, in which the current density J isproportional to the exponential of the magnetic potential andmoveover falls off exponentially with distance vertical to thebase with an e-folding distance equal to the gravitational scaleheight. 相似文献