Identification of pyrrolo-pyridine derivatives as novel class of antibacterials

Molecular Diversity - A series of 5-oxo-4H-pyrrolo[3,2-b]pyridine derivatives was identified as novel class of highly potent antibacterial agents during an extensive large-scale high-throughput...     

Energetic potential and kinetic behavior of peats

The miscibility of blends of isotactic polypropylene and propylene-1-hexene (PH) copolymers with 11 and 21 mol% of 1-hexene (PH11 and PH21, respectively) has been studied theoretically and using DSC, DMA, and AFM techniques. Using experimental PVT data, the solubility parameter approach leads to a critical difference in 1-hexene content for melt miscibility of 17 mass% (~11 mol%) at 200 °C and 0.1 MPa. The theoretical window for miscibility is in close agreement with thermal properties of the blends. The glass transition (T _g) of miscible blends (iPP/PH11 and PH11/PH21) decreases proportionally to the content of PH having the lowest T _g, while immiscible blends (iPP/PH21) display invariable T _g with blend composition. The same trend was extracted from the analysis of the β-relaxation by dynamic mechanical analysis. Room temperature AFM images of blends quenched from 200 °C into liquid nitrogen confirm phase segregation of iPP/PH21 in domains of 1–5 microns, while the AFM images of iPP/PH11 and PH11/PH21 lack any obvious signature of phase separation prior to crystallization.