Diorganotin(IV) complexes of N-mono-, di- and tri-chloroacetyl,N′,N″-bis(isopropyl) phosphoric triamide

Three new carbacylamidophosphates with formula CH_nCl_3?nC(O)NHP(O)(NHCH(CH₃)₂)₂ (n = 2 (1); n = 1 (2); n = 0 (3)) and their organotin compounds with formula (1)SnCl₂Me₂(μ-1)SnCl₂Me₂ (4), SnCl₂Me₂(2)₂·C₆H₅CH₃ (5) and [SnCl₂Me₂(3)]_n (6) were synthesized and characterized by elemental, IR and NMR spectra analyses. The spectroscopic properties of complexes were compared with those corresponding ligands. The crystal structures of complexes were determined by X-ray crystallography, which reveals that complex 4 is binuclear structure with two non-equivalent Sn atoms. One adopts a distorted trans(C,C) cis(O_P,O_P) cis(Cl,Cl) octahedral configuration, while the other adopts a distorted trigonal bipyramidal geometry composed of two methyl groups, two chlorine atoms and carbonyl group. Molecule 5 is centrosymmetric with two O_P, disordered chlorine and methyl groups in trans positions. Toluene molecules are located in the interlayer spaces of 5. In compound 6, bonding via both PO and CO functionalities forms 1D infinite chain structures along b axis. The Sn–O_P bond length in 6 is significantly longer than the same distance in 4 and 5, while the OP and Sn–Cl bonds are shorter. The bond lengths in these complexes were compared with those of N-benzoyl carbacylamidophosphates.     

Two novel diorganotin phosphonic diamides: syntheses,crystal structures,spectral properties and in vitro antibacterial studies

Two diorganotin complexes with general formulae SnCl₂(CH₃)₂[C₆H₅P(O)(NHCH(CH₃)₂)₂]₂ ( 1 ) and SnCl₂(CH₃)₂[C₆H₅P(O) (NHC(CH₃)₃)₂] ( 2 ) were prepared by the addition of one equivalent SnCl₂Me₂ to two equivalents of PhP(O)(NHⁱPr)₂ and PhP(O)(NH^tBu)₂, respectively. The compounds were characterized by elemental analysis, IR and multinuclear NMR (¹H, ¹³C, ³¹P and ¹¹⁹Sn) spectroscopy. The crystal structures of the complexes were determined by X‐ray single crystal analysis, which revealed that complex 1 has a distorted octahedral geometry and complex 2 has a distorted trigonal bipyramidal structure with non‐equivalent chlorine atoms. Preliminary antibacterial tests of the compounds against Gram‐positive and ‐negative bacteria were carried out using the filter paper disk method and chloroamphenicol was used as standard for comparison. Copyright © 2010 John Wiley & Sons, Ltd.     

Monophosphoramide derivatives: synthesis and crystal structure,theoretical and experimental studies of their biological effects

Molecular Diversity - Synthesizing new chemical compounds and studying their biological applications have been important issues in scientific research. In this investigation, we synthesized and...