A Novel Magnetic Polyethylene Glycol Nanocomposite based on Graphite Reinforcement Carbon Paste Electrode for Voltammetric Determination of Perindopril L-arginine

Journal of Analytical Chemistry - The present study reports the development of a magnetic polyethylene glycol nanocomposite based on graphite reinforcement carbon paste electrode for the sensitive...     

Baclofen impurities: Facile synthesis and novel environmentally benign chromatographic method for their simultaneous determination in baclofen

An efficient, economic and high yielding method was described for the synthesis of baclofen (BAC) pharmacopoeial impurities (impurity A and impurity B) which can be used for gram‐scale synthesis. Furthermore, a novel ecofriendly thin‐layer chromatographic TLC–densitometric method was established and validated for the determination of BAC and its synthesized impurities. The developed TLC–densitometric method is based on the chromatographic separation using TLC plates (60 F₂₅₄) using a green mobile phase of ethyl acetate–methanol–ammonia solution, 33% (8:2:0.1, by volume) with UV scanning at 220 nm. The proposed method was validated with respect to International Conference on Harmonization guidelines. The validated method was successfully applied for determination of BAC in pure form and in its commercial dosage form. Additionally, the greenness profile of the developed method was evaluated and compared with those of the reported chromatographic methods. The developed method was found to be superior to the published methods, being environmentally benign.     

Synthesis of 3,3′-methylenebis(4-hydroxyquinolin-2(1H)-ones) of prospective anti-COVID-19 drugs

Molecular Diversity - During formylation of 2-quinolones by DMF/Et3N mixture, the unexpected 3,3′-methylenebis(4-hydroxyquinolin-2(1H)-ones) were formed. The discussed mechanism was proved as...     

Determination of metformin hydrochloride in tablets by nuclear magnetic resonance spectrometry

The ¹H-n.m.r. signal of the drug (10–35 mg ml^?1) in deuterium oxide, with maleic acid as internal reference standard, is used. The integral of the peak at 3.06 ppm with respect to 3-trimethylsilylpropionic acid is compared with that at 6.3 ppm for the internal standard. The method is quantitative and free from interference by tablet excipients.     

Determination of quaternary ammonium surfactants in pharmaceutical formulations by the hypochromic effect

A spectrophotometric procedure for determination of the quaternary ammonium salts cetrimide (N,N,N-trimethyl-l-hexadecylammonium bromide), cetylpyridinium chloride (l-hexadecyl-pyridinium chloride) and sapamine [N-(2-dimethylaminoethyl)oleamide acetate] in bulk form and some pharmaceutical formulations, such as eye-drops, disinfectant solutions, creams and tablets, is described. Following TLC separation when necessary, addition of an aqueous solution of the active surfactant to a standard amount of Bromothymol Blue, buffered at pH 7.5, leads to an equivalent decrease of the absorbance at 610 nm, which can be taken as an analytical measure of the drug concentration. Good mean recoveries have been obtained for standard additions of these analytes to pharmaceutical formulations containing them.     

Existence of exotic proton-kaon four particle system

Existence of the exotic proton-kaon four particle system p ⁺ k ⁻ p ⁻ k ⁺ is investigated. The Rayleigh-Riyz variational technique is used in calculations. The system tested is found to exist as bound state and its binding energy is calculated.     

Novel Triazole-, Oxadiazole-, and Pyrazole-Nicotinonitrile Hybrids: Synthesis,DFT Study,Molecular Docking,and Antimicrobial Activity

Russian Journal of General Chemistry - The present study is devoted to functionalization of ethyl 2-{[3-cyano-6-(4-cyanophenyl)-4-(2,4-dichlorophenyl)pyridin-2-yl]oxy}acetate (1) by triazole-,...     

Quantumness Measures for a System of Two Qubits Interacting with a Field in the Presence of the Time-Dependent Interaction and Kerr Medium

In this work, we introduce the standard Tavis-Cummings model to describe two-qubit system interacting with a single-mode field associated to power-law (PL) potentials. We explore the effect of the time-dependent interaction and the Kerr-like medium. We solve the Schrödinger equation to obtain the density operator that allows us to investigate the dynamical behaviour of some quantumness measures, such as von Neumann entropy, negativity and Mandel’s parameter. We provide how these entanglement measures depend on the system parameters, which paves the way towards better control of entanglement generation in two-qubit systems. We find that the enhancement and preservation of the atoms-field entanglement and atom-atom entanglement can be achieved by a proper choice of the initial parameters of the field in the absence and presence of the time-dependent interaction and Kerr medium. We examine the photons distribution of the field and determine the situations for which the field exhibits super-poissonian, poissonian or sub-poissonian distribution.     

Evidences for Chelating Complexes of Lithium with Phenylphosphinic and Phenylphosphonic Acids: A Spectroscopic and DFT Study

Abstract

Lithium complexes were prepared with phenylphosphinic and phenylphosphonic acids. The complexes were studied in the solid state using Fourier transform infrared spectroscopy spectroscopy and in solution (methanol) using ¹H, ¹³C, and ³¹P Nuclear magnetic resonance spectroscopy (NMR) spectroscopy; the most preferred structures of the complexes were determined by density functional theory (DFT) computational method. Although methanol has a strong solvation effect on lithium ions and ligands, which causes dissociation of the complexes, significant changes of the NMR spectra of the complexes (relative to those of the free ligands) were observed. The new spectroscopic results indicate the presence of the phenylphosphinic acid tautomer (I: C₆H₅PH(?O)OH) rather than that of phenyl-phosphorous acid (II: C₆H₅P(OH)₂) in deuterated methanol showing PH/PD exchange. On the other hand, tautomer I predominates in the complex with lithium without showing PH/PD exchange. The DFT calculations predict that tautomer I is the preferred structure in the case of free ligand and lithium complex. The absence of a PH/PD exchange in the complex is due to the formation of a chelating complex, rather than of a simple salt between lithium ion and the two oxygen atoms of I, which prevent tautomerization of I into II. DFT calculations support the formation of lithium chelating complexes. The lithium ion was found to affect the spectroscopic properties of phenylphosphinic acid more dramatically than those of phenylphosphonic acid.