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排序方式: 共有47条查询结果,搜索用时 15 毫秒
1.
Armstrong TA Bettoni D Bharadwaj V Biino C Borreani G Broemmelsiek D Buzzo A Calabrese R Ceccucci A Cester R Church M Dalpiaz P Dalpiaz PF Dibenedetto R Dimitroyannis D Fabbri MG Fast J Gianoli A Ginsburg CM Gollwitzer K Hahn A Hasan M Hsueh S Lewis R Luppi E Macrí M Majewska AM Mandelkern M Marchetto F Marinelli M Marques J Marsh W Martini M Masuzawa M Menichetti E Migliori A Mussa R Palestini S Pallavicini M Pastrone N Patrignani C Peoples J Pesando L Petrucci F Pia MG Pordes S Rapidis P 《Physical review letters》1992,69(16):2337-2340
2.
Armstrong TA Bettoni D Bharadwaj V Biino C Borreani G Broemmelsiek D Buzzo A Calabrese R Ceccucci A Cester R Church M Dalpiaz P Dalpiaz PF Dimitroyannis D Fabbri M Fast J Gianoli A Ginsburg CM Gollwitzer K Govi G Hahn A Hasan M Hsueh S Lewis R Luppi E Macrí M Majewska AM Mandelkern M Marchetto F Marinelli M Marques J Marsh W Martini M Masuzawa M Menichetti E Migliori A Mussa R Palestini S Pallavicini M Passaggio S Pastrone N Patrignani C Peoples J Petrucci F Pia MG Pordes S Rapidis P Ray R 《Physical review D: Particles and fields》1996,54(11):7067-7070
3.
Pavan B Dalpiaz A Ciliberti N Biondi C Manfredini S Vertuani S 《Molecules (Basel, Switzerland)》2008,13(5):1035-1065
This review describes specific strategies for targeting to the central nervous system (CNS). Systemically administered drugs can reach the brain by crossing one of two physiological barriers resistant to free diffusion of most molecules from blood to CNS: the endothelial blood-brain barrier or the epithelial blood-cerebrospinal fluid barrier. These tissues constitute both transport and enzymatic barriers. The most common strategy for designing effective prodrugs relies on the increase of parent drug lipophilicity. However, increasing lipophilicity without a concomitant increase in rate and selectivity of prodrug bioconversion in the brain will result in failure. In these regards, consideration of the enzymes present in brain tissue and in the barriers is essential for a successful approach. Nasal administration of lipophilic prodrugs can be a promising alternative non-invasive route to improve brain targeting of the parent drugs due to fast absorption and rapid onset of drug action. The carrier-mediated absorption of drugs and prodrugs across epithelial and endothelial barriers is emerging as another novel trend in biotherapeutics. Several specific transporters have been identified in boundary tissues between blood and CNS compartments. Some of them are involved in the active supply of nutrients and have been used to explore prodrug approaches with improved brain delivery. The feasibility of CNS uptake of appropriately designed prodrugs via these transporters is described in detail. 相似文献
4.
5.
J.J. Aubert G. Bassompierre K.H. Becks C. Best E. Böhm X. de Bouard F.W. Brasse C. Broll S. Brown J. Carr R.W. Clifft J.H. Cobb G. Coignet F. Combley G.R. Court J.M. Crespo P.F. Dalpiaz S.J. Wimpenny 《Physics letters. [Part B]》1980,95(2):306-310
The transverse momenta of charged hadrons produced in high energy muon-proton scattering have been studied. The average squared transverse momentum 〈p2⊥〉 shows a strong dependence on z = Eh/v characteristic of intrinsic momentum effects and a significant rise as a function of s = W2. The W2, q2, x and z dependences of the data are compared with the predictions of a perturbative QCD model. 相似文献
6.
G. Bassompierre G. Binder P. Dalpiaz P.F. Dalpiaz G. Gissinger S. Jacquey C. Peroni A. Ruzza M.A. Scheegans L. Tecchio 《Physics letters. [Part B]》1976,65(4):397-400
Stopping antiprotons in a hydrogen target, 26 electron pairs have been found, which can be attributed to the reaction . The analysis of the data supports the existence of the ρ″ (1600) and the ρ′ (1250) mesons. 相似文献
7.
G. Bassompierre G. Binder P. Dalpiaz P.F. Dalpiaz G. Gissinger S. Jacquey C. Peroni M.A. Schneegans L. Tecchio 《Physics letters. [Part B]》1977,68(5):477-479
From the measurement of , obtained in an experiment at CERN with antiprotons at rest, a value of the proton electromagnetic form factors at the threshold of the time-like region is derived: |GE| = |GM| = 0.51 ± 0.08 at q2 = -3.52 (GeV/c)2. 相似文献
8.
Armstrong TA Bettoni D Bharadwaj V Biino C Borreani G Broemmelsiek D Buzzo A Calabrese R Ceccucci A Cester R Church MD Dalpiaz P Dalpiaz PF Fast JE Ferroni S Ginsburg CM Gollwitzer KE Hahn AA Hasan MA Hsueh SY Lewis RA Luppi E Macr M Majewska A Mandelkern MA Marchetto F Marinelli M Marques JL Marsh W Martini M Masuzawa M Menichetti E Migliori A Mussa R Palestini S Pastrone N Patrignani C Peoples J Pesando L Petrucci F Pia MG Pordes S Rapidis PA Ray RE Reid JD Rinaudo G Rosen JL Santroni A 《Physical review letters》1992,68(10):1468-1471
9.
Armstrong TA Bettoni D Bharadwaj V Biino C Borreani G Broemmelsiek D Buzzo A Calabrese R Ceccucci A Cester R Church MD Dalpiaz P Dalpiaz PF Dibenedetto R Dimitroyannis D Fabbri MG Fast JE Gianoli A Ginsburg CM Gollwitzer KE Hahn AA Hasan MA Hsueh SY Lewis RA Luppi E Macrí M Majewska A Mandelkern MA Marchetto F Marinelli M Marques JL Marsh W Martini M Masuzawa M Menichetti E Migliori A Mussa R Palestini S Pallavicini M Passaggio S Pastrone N Patrignani C Peoples J Pesando L Petrucci F Pia MG 《Physical review D: Particles and fields》1993,47(3):772-783
10.
Catia Contado Eleonora Vighi Alessandro Dalpiaz Eliana Leo 《Analytical and bioanalytical chemistry》2013,405(2-3):703-711
Poly(lactic-co-glycolic acid) particles in the 200–400-nm size range were formulated through nanoprecipitation and solvent evaporation methods. Different concentrations of the polymer and stabilizer (Pluronic® F 68) were tested in order to identify the best conditions for making poly(lactic-co-glycolic acid) particles of suitable size, stable in time, and to be used as carriers for brain-targeting drugs. The particles with the best characteristics for delivery system design were those formulated by nanoprecipitation with an organic/water phase ratio of 2:30, a polymer concentration of 25 mg/mL, and a surfactant concentration of 0.83 mg/mL; their surface charge was reasonably negative (approximately -27 mV) and the average size of the almost monodisperse population was roughly 250 nm. Particle characterization was obtained through ζ-potential measurements, scanning electron microscope observations, and particle size distribution determinations; the latter achieved by both photon-correlation spectroscopy and sedimentation field flow fractionation. Sedimentation field flow fractionation, which is considered more reliable than photon-correlation spectroscopy in describing the possible particle size distribution modifications, was used to investigate the effects of 3 months of storage at 4 °C had on the lyophilized particles. Figure
Particle size ditribution from the SdFFF and the PCS techniques 相似文献