Reconstitution of Nucleosome Demethylation and Catalytic Properties of a Jumonji Histone Demethylase

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Highlights? Catalytic domain of JMJD2A (cJMJD2A) removes methyl marks in a distributive manner ? Homogeneously methylated nucleosomes were used as substrates ? Quantitative assay for nucleosome demethylation has been developed     

Patent tactics in molecular diversity: Things that get around,come around (Or: There are always exceptions to the rule)

Certain activities which would constitute infringement of a U.S. patent can come within a statutory exemption when the activity is carried out to obtain FDA approval. Exemptions to infringement provided by 35 U.S.C. §271(e)(1) are discussed along with recent cases interpreting this statute. The evolution of the statute in providing an exemption to activities necessary to obtain FDA marketing approval is described to provide background, legislative intent and show a comparative of the law before and after 1984 when 271(e)(1) was enacted. By analyzing recent cases, criteria for qualifying an activity as exempt from infringement are described – as are activities that do not qualify for the 271(e)(1) exemption. Overall there appears to be a trend to more broadly allowing for activities to qualify as exempt from infringement. This trend may affect the value of patents and determine which technologies a company will seek patent protection on.     

Characteristic cycles of standard sheaves associated with open orbits

Let be a real form of a complex, semisimple Lie group . We compute the characteristic cycle of a standard sheaf associated with an open -orbit on the partial flag variety of . We apply the result to obtain a Rossmann-type integral formula for elliptic coadjoint orbits. These results were previously obtained by the author under the assumption that the rank of is equal to the rank of a maximal compact subgroup.

     

The associated variety of an induced representation

This paper studies the behavior of the associated variety under induction from real parabolic subgroups. We derive a formula for the associated variety of an induced module which is analogous to the formula for the wave front set of a derived functor module obtained by Barbasch and Vogan.

     

Analyzing and visualizing the semantic coverage of Wikipedia and its authors

This article presents a novel analysis and visualization of English Wikipedia data. Our specific interest is the analysis of basic statistics, the identification of the semantic structure and the age of the categories in this free online encyclopedia, and the content coverage of its highly productive authors. © 2007 Wiley Periodicals, Inc. Complexity: 12: 30–40, 2007