Chemical transformations of 3‐amino‐2‐quinolones

In order to find new antimalarial drugs, an exploration about the chemical properties of the starting compounds 3‐amino‐6‐chloro‐4‐phenyl‐1H‐quinolin‐2‐one ( 1 ) and 3‐amino‐4‐methyl‐1H‐quinolin‐2‐one ( 2 ) was developed. Acylation with acyl chloride, sulfonyl chloride and acetic anhydride were carried out. Despite a previous report [2], when acetyl chloride or acetic anhydride were assayed on 1 , only the diacetyl derivative 7 was obtained. When this compound was heated at reflux temperature in a mixture of acetic acid and acetic anhydride, it was transformed in the oxazoloquinoline 8 . Further reactions of the acyl derivatives with diazomethane afforded 1‐methylated compounds. Compound 2 gave the imine 16 by condensation with 4‐nitrobenzaldehyde.     

Acoplanar (e+e−) pairs and radiative corrections

Further proof is given for the inadequacy of the peaking approximation in first-order radiative corrections, via the observation of 429 non-coplanar (e⁺e^?) events. The energy dependence of this effects is measured in the s-range 1.44 to 9.0 GeV², and represents another proof of the validity of QED.     

ee Annihilation into two hadrons in the energy interval 1400–2400 MeV

The proof is given for the existence of the reaction e⁺e⁻ → h^±h^? in the energy range 1400–2400 MeV, and its energy dependence is compared with that of e⁺e⁻ → e^±e^?, in the same experimental conditions of observation. The exponent of the s-dependence of the ratio α = (e⁺e⁻ → h^±h^?)/ (e⁺e⁻ → e^±e^?) is measured to be n = 2.08 ± 0.45, in the s-range (1.96 − 5.76) GeV², on the basis of 51 e⁺e⁻ → h^±h^? events and 8918 e⁺e⁻ → e^±e^? events observed.     

Coupling of Tachyons to Electromagnetism

We consider a fourth-order equation implying abradyonic and a tachyonic mode of propagation for ascalar field. The electromagnetic field is introducedvia the gauge covariant derivative. We show that the interacting fourth-order equation isequivalent to a second-order Klein-Gordon equation alsominimally coupled, with the tachyon living in closedloops connected only to photon lines. The equivalence shows that the fourth-order theory isrenormalizable and unitary.     

Microwave-assisted rapid and efficient synthesis of C-alkyl imidazoisoquinolinone derivatives

The synthesis of a set of 10-benzyl-2,3-dihydroimidazo[1,2-b]isoquinolin-5(1H)-one and 5-oxo-imidazo[1,2-b]isoquinolin-10-yl)-N-phenylacetamide derivatives was achieved by exposing the corresponding alkylating agent and imidazoisoquinolinone to microwave irradiation and traditional oil bath heating in the presence of K₂CO₃ and DMAP. The microwave technique as well as DMAP as base accelerated the alkylation reaction for 2-6 min giving 79-88% yields.     

Low-Temperature,Ambient Pressure Oxidation of Methane to Methanol Over Every Tri-Iron Node in a Metal–Organic Framework Material

In contrast with metal-modified zeolites, metal–organic framework materials (MOFs) provide a platform that may be significantly more amenable to creating catalysts in which every metal site is endowed with the same coordination environment, and hence, catalytic function. Using MIL-100(Fe) as a prototype, we present the first example of a synthetic heterogeneous catalyst comprised exclusively of active tri-iron moieties participating in the low-temperature oxidation of methane to methanol; in contrast with prior reports on iron-MOFs, we report the near-exclusive formation of methanol at low temperatures and sub-ambient methane pressures, and evidence its effectuation solely by Fe²⁺ sites. The study captures the utility of exploring classes of materials endowed with a high level of definition in structure and catalytic function for the purposes of overcoming persistent scientific and technological challenges in the field of synthetic heterogeneous catalysis.     

Graphical linking of a MO multicenter bond index to VB structures

The multicenter bond index proposed within the MO framework depends on the order of the centers for which it is calculated, outside from the 3-c case. For the 6-c case, the eventually different values are 60. A graphical approach links the MO values to VB structures. Benzene, chosen as our paradigm for the 6-c case, illustrates our proposition.