Mechanism of nanocapsules of Matricaria recutita L. extract formation by the emulsion–diffusion process

Nanocapsules coated by medicinal plants have many applications in drug manufacturing. Medicinal plants can be loaded on nanocapsules with polyesteric triblock copolymer poly ethylene glycol–poly butylene adipate–poly ethylene glycol (PEG–PBA–PEG) as shell and olive oil can be introduced as a core of nanocapsules by a method known as polymer deposition solvent evaporation method. In this research, first, certain amount of polymer, Matricaria recutita extract and olive oil were mixed with acetone and then, water was added to the solution using magnetic stirrer. After which the acetone was removed by vacuuming and finally nanocapsules were found by freezing-drier. The study showed the size of nanocapsules depends on variety of factors such as the ratio of polymer to oil and concentration of polymers and plant extract. The nanocapsules were identified by scanning electron microscopy (SEM) and zeta potential sizer (ZPS), Fourier-transform infrared spectroscopy (FT-IR), and nuclear magnetic resonance (NMR).