Copper and iron interactions with angiotensin-converting enzyme inhibitors. A study by fast-atom bombardment tandem mass spectrometry

Fast atom bombardment, combined with high-energy collision-induced tandem mass spectrometry, has been used to investigate gas-phase metal-ion interactions with captopril, enalaprilat and lisinopril, all angiotensin-converting enzyme inhibitors.Suggestions for the location of metal-binding sites are presented. For captopril, metal binding occurs most likely at both the sulphur and the nitrogen atom. For enalaprilat and lisinopril, binding preferably occurs at the amine nitrogen. Copyright 1999 John Wiley & Sons, Ltd.     

A method for analysing nesting techniques for the linearized shallow water equations

A method for analysing different nesting techniques for the linearized shallow water equations is presented. The problem is formulated as an eigenvector–eigenvalue problem. A necessary condition for stability is that the spectral radius of the propagation matrix is less than or equal to one. Two test cases are presented. The first test case is analysed, and effects of enforcing volume conservation and nudging in time are studied. A nesting technique is found that causes no growth of any eigenvectors for reasonable time steps. This nesting technique is then used on both test cases, and results are compared to an everywhere refined model and a coarse grid model. Copyright © 2002 John Wiley & Sons, Ltd.     

New class of dynamics in concentrated polymer gels

We show that concentrated poly(methyl methacrylate) solution exhibits a new class of coupled dynamics, which can be regarded as an intermediate between the collective diffusion of solutions and the structural relaxations of glasses. This class of dynamics have a relaxation rate that is directly proportional to the wave vector. The transition from diffusive to coupled collective dynamics occurs at smaller length scales with increasing polymer concentration and decreasing temperature. The experimental observations can be understood by considering the contributions from physical cross-links interconnected by stiff polymer segments.