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1.
Alan Rigter Jan PM Langeveld Drophatie Timmers-Parohi Jorg G Jacobs Peter LJM Moonen Alex Bossers 《BMC biochemistry》2007,8(1):6
Background
The common event in transmissible spongiform encephalopathies (TSEs) or prion diseases is the conversion of host-encoded protease sensitive cellular prion protein (PrPC) into strain dependent isoforms of scrapie associated protease resistant isoform (PrPSc) of prion protein (PrP). These processes are determined by similarities as well as strain dependent variations in the PrP structure. Selective self-interaction between PrP molecules is the most probable basis for initiation of these processes, potentially influenced by chaperone molecules, however the mechanisms behind these processes are far from understood. We previously determined that polymorphisms do not affect initial PrPC to PrPSc binding but rather modulate a subsequent step in the conversion process. Determining possible sites of self-interaction could elucidate which amino acid(s) or amino acid sequences contribute to binding and further conversion into other isoforms. To this end, ovine – and bovine PrP peptide-arrays consisting of 15-mer overlapping peptides were probed with recombinant sheep PrPC fused to maltose binding protein (MBP-PrP). 相似文献2.
3.
Mixing rules are derived for mass diffusion coefficient and thermal diffusion factor matrices by developing compatibility conditions between the fluid mixture equations obtained from nonequilibrium thermodynamics and Grad's 13-moment kinetic theory. The mixing rules are shown to be in terms of the species mole fractions and binary processes. In particular, the thermal diffusion factors for binary mixtures obtained by the Chapman-Enskog expansion procedure are suitably generalized for many-component mixtures. Some practical aspects of the results are discussed including the utilization of these mixing rules for high pressure situations. 相似文献
4.
Metal/superconductor/semiconductor (Ag/Hg-1212/CdSe) hetero-nanostructures have been fabricated using pulse-electrodeposition
technique and are characterized by X-ray diffraction (XRD), full-width at half-maximum (FWHM) and scanning electron microscopy
(SEM) studies. The junction capacitance of Ag/Hg-1212, Hg-1212/CdSe and Ag/Hg-1212/CdSe heterojunctions is measured in dark
and under laser irradiation at room temperature. The nature of the junction formed and built-in-junction potentials were determined.
The increase in carrier concentration across the junction due to photo-irradiation has been observed. 相似文献
5.
One of the innovative technological directions for the high-temperature superconductors has been persued by fabricating the
heteroepitaxial multilayer structures such as superconductor-semiconductor heterostructures. In the present investigation,
metal/superconductor/semiconductor (Ag/Tl-2223/CdSe) hetero-nanostructures have successfully been fabricated using dc electrodeposition
technique and were characterized by X-ray diffraction (XRD), full-width at half-maximum (FWHM) and scanning electron microscopy
(SEM) studies. The measurement of junction capacitance as a function of biasing voltage was used for the estimation of junction
built-in-potential (V
D) and to study the charge distribution in a heterojunction. The Mott-Schottky plots were measured for each junction in dark
and under the photo-irradiation. The effect of laser irradiation on C-V characteristics of hetero-nanostructure has been studied. 相似文献
6.
Abazov VM Abbott B Abolins M Acharya BS Adams M Adams T Aguilo E Ahn SH Ahsan M Alexeev GD Alkhazov G Alton A Alverson G Alves GA Anastasoaie M Ancu LS Andeen T Anderson S Andrieu B Anzelc MS Arnoud Y Arov M Arthaud M Askew A Asman B Assis Jesus AC Atramentov O Autermann C Avila C Ay C Badaud F Baden A Bagby L Baldin B Bandurin DV Banerjee S Banerjee P Barberis E Barfuss AF Bargassa P Baringer P Barreto J Bartlett JF Bassler U Bauer D Beale S Bean A Begalli M Begel M Belanger-Champagne C 《Physical review letters》2008,100(19):192003
We present the first simultaneous measurement of the ratio of branching fractions, R=B(t --> Wb)/B(t --> Wq), with q being a d, s, or b quark, and the top-quark pair production cross section sigma(tt[over]) in the lepton plus jets channel using 0.9 fb(-1) of pp[over] collision data at sqrt(s)=1.96 TeV collected with the D0 detector. We extract R and sigma(tt[over]) by analyzing samples of events with 0, 1, and > or =2 identified b jets. We measure R=0.97(+0.09)/(-0.08)(stat+syst) and sigma(tt[over])=8.18(+0.09)(-0.84)(stat+syst) +/- 0.50(lumi) pb, in agreement with the standard model prediction. 相似文献
7.
Abazov VM Abbott B Abolins M Acharya BS Adams M Adams T Aguilo E Ahn SH Ahsan M Alexeev GD Alkhazov G Alton A Alverson G Alves GA Anastasoaie M Ancu LS Andeen T Anderson S Andrieu B Anzelc MS Arnoud Y Arov M Arthaud M Askew A Asman B Assis Jesus AC Atramentov O Autermann C Avila C Ay C Badaud F Baden A Bagby L Baldin B Bandurin DV Banerjee S Banerjee P Barberis E Barfuss AF Bargassa P Baringer P Barreto J Bartlett JF Bassler U Bauer D Beale S Bean A Begalli M Begel M Belanger-Champagne C 《Physical review letters》2008,100(14):142002
We present the first measurement of the integrated forward-backward charge asymmetry in top-quark-top-antiquark pair (tt) production in proton-antiproton (pp) collisions in the lepton+jets final state. Using a b-jet tagging algorithm and kinematic reconstruction assuming tt + X production and decay, a sample of 0.9 fb(-1) of data, collected by the D0 experiment at the Fermilab Tevatron Collider, is used to measure the asymmetry for different jet multiplicities. The result is also used to set upper limits on tt+X production via a Z' resonance. 相似文献
8.
Abazov VM Abbott B Abolins M Acharya BS Adams M Adams T Aguilo E Ahn SH Ahsan M Alexeev GD Alkhazov G Alton A Alverson G Alves GA Anastasoaie M Ancu LS Andeen T Anderson S Andrieu B Anzelc MS Arnoud Y Arov M Arthaud M Askew A Asman B Assis Jesus AC Atramentov O Autermann C Avila C Ay C Badaud F Baden A Bagby L Baldin B Bandurin DV Banerjee S Banerjee P Barberis E Barfuss AF Bargassa P Baringer P Barreto J Bartlett JF Bassler U Bauer D Beale S Bean A Begalli M Begel M Belanger-Champagne C 《Physical review letters》2008,100(8):082002
We report the direct observation of the excited L=1 state B_(s2)(*) in fully reconstructed decays to B+K-. The mass of the B_(s2)(*) meson is measured to be 5839.6+/-1.1(stat)+/-0.7(syst) MeV/c(2), and its production rate relative to the B+ meson is measured to be [1.15+/-0.23(stat)+/-0.13(syst)]%. 相似文献
9.
Titanium oxide thin films have been deposited by an ion plating technique under rf glow. The structure of the deposited film has been found to be amorphous and the composition has been analysed by IR spectrum. Aging and annealing studies of the titanium oxide capacitors have been made. The dielectric constant of the film at 1 kHz has been estimated to be 12.4. The dependence of the capacitance and dielectric loss on frequency and temperature have been studied, and the results are discussed. The temperature coefficient of the capacitance has also been calculated. 相似文献
10.
Despite the burgeoning interest in the various biological functions and consequent therapeutic potential of the vast number of oligosaccharides found in nature on glycoproteins and cell surfaces, the development of combinatorial carbohydrate chemistry has not progressed as rapidly as expected. The reason for this imbalance is rooted in the difficulty of oligosaccharide assembly and analysis that renders synthesis a rather cumbersome endeavor. Parallel approaches that generate series of analogous compounds rather than real libraries have therefore typically been used. Since generally low affinity is obtained for interactions between carbohydrate receptors and modified oligosaccharides designed as mimetics of natural carbohydrate ligands, glycopeptides have been explored as alternative mimics. Glycopeptides have been proven in many cases to be superior ligands with higher affinity for a receptor than the natural carbohydrate ligand. High-affinity glycopeptide ligands have been found for several types of receptors including the E-, P-, and L-selectins, toxins, glycohydrolases, bacterial adhesins, and the mannose-6-phosphate receptor. Furthermore, the assembly of glycopeptides is considerably more facile than that of oligosaccharides and the process can be adapted to combinatorial synthesis with either glycosylated amino acid building blocks or by direct glycosylation of peptide templates. The application of the split and combine approach using ladder synthesis has allowed the generation of very large numbers of compounds which could be analyzed and screened for binding of receptors on solid phase. This powerful technique can be used generally for the identification and analysis of the complex interaction between the carbohydrates and their receptors. 相似文献