Organocatalyzed Kabbe condensation reaction for mild and expeditious synthesis of 2,2-dialkyl and 2-spiro-4-chromanones

An expeditious Kabbe condensation reaction for the synthesis of 2,2-dialkyl and 2-spiro-chroman-4(1H)-ones has been developed using pyrrolidine-butanoic acid in DMSO as bifunctional organocatalyst. Unlike existing methods, this reaction proceeds at room temperature with high yields, rendering it an attractive method to synthesize a vast variety of privileged 4-chromones.     

Development and Validation of the Ultraviolet Spectrophotometric Method for Determination of Erlotinib Hydrochloride

Journal of Applied Spectroscopy - A simple, accurate, novel, safe, and precise method was developed for the estimation of erlotinib hydrochloride in tablet dosage form using a mixture of methanol...