排序方式: 共有9条查询结果,搜索用时 15 毫秒
1
1.
K.K. Abdul Khader Ayyiliath M. Sajith M. Syed Ali Padusha H.P. Nagaswarupa A. Muralidharan 《Tetrahedron letters》2014
In this Letter we report a rapid and facile access to C2-substituted imidazo[4,5-b]pyridine analogues utilizing palladium mediated Buchwald–Hartwig cross-coupling reactions. The use of enolizable heterocycles as cross-coupling partners resulted in a wide range of imidazo[4,5-b]pyridine analogues which are prone to have medicinal relevance. Xantphos and Pd(OAc)2 were found to be more effective for the coupling of 2-halo imidazo[4,5-b]pyridines with pyridone nucleophiles. A regioselective approach for the synthesis of 2-substituted 3H-imidazo[4,5-b]pyridine and 1H-imidazo[4,5-b]pyridine is also reported. 相似文献
2.
Kulkarni B. Manjunatha K. Joy Muthipeedika Nibin Sajith Ayyiliath Meleveetil Prashantha C. N. Pakkath Ranjith Alshammari Mohammed B. 《Molecular diversity》2022,26(5):2893-2905
Molecular Diversity - We herein report the facile synthesis of a series of 3,5-substituted-1,2,4-oxadiazole derivatives in good to excellent yields. The anti-inflammatory potential of the newly... 相似文献
3.
Ayyiliath M. Sajith 《Tetrahedron letters》2012,53(9):1036-1041
A modified approach for the synthesis of 3-substituted 2-aryl/heteroaryl imidazo[4,5-b]pyridines utilising palladium catalysed cross-coupling reactions under microwave enhanced conditions has been achieved. utilisation of (A-taphos)2PdCl2-catalysed cross-coupling reactions enables rapid derivatization of this (imidazo[4,5-b]pyridines) pharmaceutically relevant core. This catalytic system is compatible with a broad spectrum of arylboronic acids—electron rich, electron poor, and heteroarylboronic acids. 相似文献
4.
Nagaraja Reddy Gangarapu A. Ranganatham Eeda Koti Reddy H. D. Surendra Ayyiliath M. Sajith Shivaraj Yellappa Kothapalli Bannoth Chandrasekhar 《Journal of heterocyclic chemistry》2019,56(3):1117-1126
A novel series of 3,5‐disubstituted‐2‐pyrazineamide derivatives ( 5a–5o ) were synthesized and studied for their potential as antitubercular agents. Among them, the compounds 5a , 5g , and 5m showed the good minimal inhibitory concentration of 20, 25, and 25 μg/mL, respectively. The compound 5a displayed excellent minimum inhibitory concentration of 10 μg/mL and is four times more potent compared with the standard drug, rifampicin concentration. In silico docking studies revealed that the compounds 5a and 5c can bind strongly in the active site of 2FUM enzyme and prevent enzyme–substrate interactions. In addition, in silico docking studies were calculated, and based on the data obtained, compound 5a displayed excellent drug‐like properties. 相似文献
5.
Bhaskaran Savitha Eeda Koti Reddy C.S. Ananda Kumar Ranjith P. Karuvalam M. Syed Ali Padusha Vasiliy A. Bakulev Kereyagalahally H. Narasimhamurthy Ayyiliath M. Sajith Muthipeedika Nibin Joy 《Tetrahedron letters》2019,60(52):151332
An efficient methodology is reported for the regioselective C-6 arylation of protected uracil via the palladium catalyzed CH functionalization of 1-(4-methoxybenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione with (hetero)aryl halides and boronic acids. Utilization of the Pd(OAc)2/Xantphos catalytic system with a stoichiometric amount of CuI and DBU as the base was vital for the success of this protocol. The methodology is facile and compatible with aryl bromides, iodides and boronic acids and hence affords broad substrate scope and diversity. 相似文献
6.
Ayyiliath M. Sajith 《Tetrahedron letters》2012,53(39):5206-5210
Enhancing the reactivity of the catalytic system by using palladium catalyst with sterically demanding and electron rich ligands attached to it has often been shown as an appropriate way of performing the copper-free Sonogashira reaction. In this paper, we report PdCl2(PCy3)2 as an efficient catalyst for the copper and amine-free Sonogashira cross coupling reactions of 2-halo-3-alkyl imidazo[4,5-b]pyridines (I, Br, Cl) using tetrabutyl ammonium acetate as an activator under microwave enhanced conditions. 相似文献
7.
Gem-dibromomethylarenes are considered as one of the valuable building blocks in the synthetic field because of their broad range of synthetic applications. These synthons serve as useful intermediates in accessing a varied range of (hetero) aromatic frameworks that can act as vital scaffolds in agrochemicals, medicinal chemistry, material sciences, etc. The additional organic transformations that can be performed using these vital reagents highlights its significance in the area of organic synthesis. This review aims at displaying some discoveries and subsequent improvements of this vital intermediate as an important building block in organic transformations. 相似文献
8.
Savitha Bhaskaran Reddy Eeda Koti Parthasarathi D. Pakkath Rajeesh Karuvalam Ranjith Pakkath Ananda Kumar C. S. Haridas K. R. Syed Ali Padusha M. Sajith Ayyiliath M. 《Molecular diversity》2019,23(3):697-707
Molecular Diversity - An expedient catalytic method for the synthesis of diverse 7-(hetero) aryl-1H-pyrrolo[2,3-c]pyridine analogues via microwave-assisted Suzuki–Miyaura cross-coupling... 相似文献
9.
Rajendra Merla Arjuna Naseem Muhammad Joy Muthipeedika Nibin Sunil K. Sajith Ayyiliath Meleveetil Howari Fares Nazzal Yousef Xavier Cijo Alshammari Mohammed B. Haridas Karickal Raman 《Molecular diversity》2022,26(3):1761-1767
Molecular Diversity - We herein report a modified methodology for the synthesis of some oxadiazoles linked to amides under mild conditions. The developed protocol using NMI-TfCl has been found to... 相似文献
1