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Dr. Talia Harris Dr. Ayelet Gamliel Atara Nardi-Schreiber Prof. Jacob Sosna J. Moshe Gomori Prof. Rachel Katz-Brull 《Chemphyschem》2020,21(3):251-256
The promise of hyperpolarized glucose as a non-radioactive imaging agent capable of reporting on multiple metabolic routes has led to recent advances in its dissolution-DNP (dDNP) driven polarization using UV-light induced radicals and trityl radicals at high field (6.7 T) and 1.1 K. However, most preclinical dDNP polarizers operate at the field of 3.35 T and 1.4–1.5 K. Minute amounts of Gd3+ complexes have shown large improvements in solid-state polarization, which can be translated to improved hyperpolarization in solution. However, this Gd3+ effect seems to depend on magnetic field strength, metal ion concentration, and sample formulation. The effect of varying Gd3+ concentrations at 3.35 T has been described for 13C-labeled pyruvic acid and acetate. However, it has not been studied for other compounds at this field. The results presented here suggest that Gd3+ doping can lead to various concentration and temperature dependent effects on the polarization of [13C6,2H7]glucose, not necessarily similar to the effects observed in pyruvic acid or acetate in size or direction. The maximal polarization for [13C6,2H7]glucose appears to be at a Gd3+ concentration of 2 mM, when irradiating for more than 2 h at the negative maximum of the DNP intensity profile. Surprisingly, for shorter irradiation times, higher polarization levels were determined at 1.50 K compared to 1.45 K, at a [Gd3+]=1.3 mM. This was explained by the build-up time constant and maximum at these temperatures. 相似文献
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Brahmbhatt Gaurangkumar C. Sutariya Tushar R. Atara Hiralben D. Parmar Narsidas J. Gupta Vivek K. Lagunes Irene Padrón José M. Murumkar Prashant R. Yadav Mange Ram 《Molecular diversity》2020,24(2):355-377
Molecular Diversity - Several new (5-aryloxy-pyrazolyl)- and (5-aryl/olefin-sulfanyl-pyrazolyl)-dibenzo[b,e] [1,4] diazepinone scaffolds have been synthesized, by assembling 5-substituted... 相似文献
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