A poly(N-isopropylacrylamide) (PNIPAAm)-like biodegradable thermosensitive polydepsipeptide, poly[Glc-Asn(N-isopropyl)], was synthesized by introducing an isopropyl amide group into poly[Glc-Asn]. Poly[Glc-Asn(N-isopropyl)] was degraded in vitro by cleavage of the ester bonds in the main chain in water at room temperature. The non-toxic nature of the polymer and its degradation products, coupled with a cloud point at 29 degrees C in water, make this polymer attractive for biomedical implant applications. 相似文献
The nuclear spin alignments of the β-emitting fragments 12B(Iπ=1+, T1/2=20.2 ms) and 13B(Iπ=3/2−, T1/2=17.4 ms) produced in the 100A-MeV 13C, 15N + 9Be collisions respectively have been observed for the first time detecting asymmetric β-ray emission from these nuclei. By
means of the spin manipulation technique based on the hyperfine interaction of B isotopes in TiO2, both the polarization P and the alignment A were determined reliably. The obtained P and A were significantly smaller than the expectation from the kinematical model. From the fact that the quenching factors for
P and A are almost the same, there may be some depolarization mechanism in the collision process itself.
This revised version was published online in September 2006 with corrections to the Cover Date. 相似文献
A low-speed screen/film system was used to investigate structure mottle, i.e., the density fluctuation of an x-ray film due to inhomogeneous screen structure. The tube voltage dependence of the Wiener spectra of the structure mottle was separately determined for front and back film emulsions. The Wiener spectral values of the structure mottle of the front emulsion were greater than those of the back emulsion at lower tube voltages. The spectral values of the structure mottle of the front emulsion decreased with tube voltage, while those of the back emulsion increased. We explain these phenomena by the behavior of the Wiener spectra of the relative spatial fluctuation of fluorescence intensity due to following reasons: (1) spatial thickness fluctuation of the screen produces a relative spatial fluctuation of x-ray energy absorbed in the screen, and (2) as the distance between the emulsion of the film and the average position of the x-ray absorption in the screen lengthens, the number of random scattering and absorption of light photons increase.Presented at the International Commission for Optics Topical Meeting, Kyoto, 1994. 相似文献
The syntheses of polylactides (PLAs) with branched peptide end groups containing reactive (ionic) moieties such as amino or carboxyl groups are described and were used to prepare PLA‐based microspheres (MSs) with positively or negatively charged surfaces. Branched peptides with hydroxyl end groups and four protected amino or carboxyl groups, Boc4‐K3‐OH or Bn4‐E3‐OH, were synthesized, and the hydroxyl group converted to an alkoxide and was used as the initiation site for the ring‐opening polymerization of L ‐lactide. Subsequent deprotection gave PLAs end‐capped with branched peptides having four amino or carboxyl groups, respectively (K3‐PLA and E3‐PLA). K3‐PLA and E3‐PLA were converted to K34+‐PLA and E34?‐PLA by acid or base treatment, respectively. MSs with charged surfaces were then prepared using K34+‐PLA or E34?‐PLA as a surfactant [MS(K34+‐PLA) or MS(E34?‐PLA)]. The ionic surface state of the MSs was confirmed by colloidal titration and zeta potential analysis.
Secondary and tertiary amines can be easily obtained from primary and secondary amines, respectively, in completely aqueous media, in the presence of a bicatalytic system formed of cheap commercial aluminum (Al) powder and 5% rhodium (Rh) or ruthenium (Ru) deposed on charcoal. 相似文献
With the aim of obtaining a porphyrin derivative useful for diagnosis and therapy of cancer, fluorine analogues of protoporphyrin, in which the vinyl group(s) were replaced by difluorovinyl group(s), were synthesized by the reaction of the formylporphyrins with sodium chlorodifluoroacetate in the presence of triphenylphosphine. Some improvements in the reported procedures for the synthesis of formylporphyrins are also described. Preliminary results of biological tests of the products showed that 8(2),8(2)-difluoroprotoporphyrin accumulates to gastric cancer more selectively than other fluorine analogues and that 3(2),3(2),8(2),8(2)-tetrafluoroprotoporphyrin is taken up by rat hepatoma cells more readily than the others. 相似文献